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Nutrients 2013, 5(5), 1672-1705; doi:10.3390/nu5051672
Review

The Relationship between Dietary Fatty Acids and Inflammatory Genes on the Obese Phenotype and Serum Lipids

1
, 1,2
 and 1,2,*
Received: 28 February 2013; in revised form: 7 April 2013 / Accepted: 10 April 2013 / Published: 21 May 2013
(This article belongs to the Special Issue Nutrients and Immune Function)
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Abstract: Obesity, a chronic low-grade inflammatory condition is associated with the development of many comorbidities including dyslipidemia. This review examines interactions between single nucleotide polymorphisms (SNP) in the inflammatory genes tumor necrosis alpha (TNFA) and interleukin-6 (IL-6) and dietary fatty acids, and their relationship with obesity and serum lipid levels. In summary, dietary fatty acids, in particular saturated fatty acids and the omega-3 and omega-6 polyunsaturated fatty acids, impact the expression of the cytokine genes TNFA and IL-6, and alter TNFα and IL-6 production. In addition, sequence variants in these genes have also been shown to alter their gene expression and plasma levels, and are associated with obesity, measures of adiposity and serum lipid concentrations. When interactions between dietary fatty acids and TNFA and IL-6 SNPs on obesity and serum lipid were analyzed, both the quantity and quality of dietary fatty acids modulated the relationship between TNFA and IL-6 SNPs on obesity and serum lipid profiles, thereby impacting the association between phenotype and genotype. Researching these diet–gene interactions more extensively, and understanding the role of ethnicity as a confounder in these relationships, may contribute to a better understanding of the inter-individual variability in the obese phenotype.
Keywords: adipose tissue; dyslipidemia; SNP; dietary fat; inflammation; ethnicity adipose tissue; dyslipidemia; SNP; dietary fat; inflammation; ethnicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Joffe, Y.T.; Collins, M.; Goedecke, J.H. The Relationship between Dietary Fatty Acids and Inflammatory Genes on the Obese Phenotype and Serum Lipids. Nutrients 2013, 5, 1672-1705.

AMA Style

Joffe YT, Collins M, Goedecke JH. The Relationship between Dietary Fatty Acids and Inflammatory Genes on the Obese Phenotype and Serum Lipids. Nutrients. 2013; 5(5):1672-1705.

Chicago/Turabian Style

Joffe, Yael T.; Collins, Malcolm; Goedecke, Julia H. 2013. "The Relationship between Dietary Fatty Acids and Inflammatory Genes on the Obese Phenotype and Serum Lipids." Nutrients 5, no. 5: 1672-1705.


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