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Mar. Drugs 2017, 15(8), 239; doi:10.3390/md15080239

Saccharomonopyrones A–C, New α-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490

1
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea
2
School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Korea
3
College of Pharmacy, Sunchon National University, Suncheon 57922, Korea
4
College of Pharmacy, Ewha Womans University, Seoul 03760, Korea
5
Research Institute of Oceanography, Seoul National University, NS-80, Seoul 08826, Korea
6
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 2 June 2017 / Revised: 13 July 2017 / Accepted: 25 July 2017 / Published: 3 August 2017
(This article belongs to the Special Issue Natural Products from Marine Actinomycetes)
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Abstract

Intensive study of the organic extract of the marine-derived bacterium Saccharomonospora sp. CNQ-490 has yielded three new α-pyrones, saccharomonopyrones A–C (13). The chemical structures of these compounds were assigned from the interpretation of 1D, 2D NMR and mass spectrometry data. Saccharomonopyrone A (1) is the first α-pyrone microbial natural product bearing the ethyl-butyl ether chain in the molecule, while saccharomonopyrones B and C possess unusual 3-methyl and a 6-alkyl side-chain within a 3,4,5,6-tetrasubstituted α-pyrone moiety. Saccharomonopyrone A exhibited weak antioxidant activity using a cation radical scavenging activity assay with an IC50 value of 140 μM. View Full-Text
Keywords: Saccharomonospora sp.; marine natural products; α-pyrones Saccharomonospora sp.; marine natural products; α-pyrones
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Yim, C.-Y.; Le, T.C.; Lee, T.G.; Yang, I.; Choi, H.; Lee, J.; Kang, K.-Y.; Lee, J.S.; Lim, K.-M.; Yee, S.-T.; Kang, H.; Nam, S.-J.; Fenical, W. Saccharomonopyrones A–C, New α-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490. Mar. Drugs 2017, 15, 239.

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