Next Article in Journal
Cladodionen, a Cytotoxic Hybrid Polyketide from the Marine-Derived Cladosporium sp. OUCMDZ-1635
Next Article in Special Issue
Fluostatins M–Q Featuring a 6-5-6-6 Ring Skeleton and High Oxidized A-Rings from Marine Streptomyces sp. PKU-MA00045
Previous Article in Journal
Exopolysaccharides from Marine and Marine Extremophilic Bacteria: Structures, Properties, Ecological Roles and Applications
Previous Article in Special Issue
Saccharomonopyrones A–C, New α-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessArticle
Mar. Drugs 2018, 16(2), 70; https://doi.org/10.3390/md16020070

Lactomycins A–C, Dephosphorylated Phoslactomycin Derivatives that Inhibit Cathepsin B, from the Marine-derived Streptomyces sp. ACT232

1
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
2
Laboratory of Aquatic Molecular Biology and Biotechnology, Graduate School of Agricultural and LifeSciences, The University of Tokyo, Tokyo 113-8657, Japan
3
Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Natsushima, Yokosuka, Kanagawa237-0061, Japan
Present address: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
*
Authors to whom correspondence should be addressed.
Received: 12 December 2017 / Revised: 12 February 2018 / Accepted: 12 February 2018 / Published: 21 February 2018
(This article belongs to the Special Issue Natural Products from Marine Actinomycetes)
View Full-Text   |   Download PDF [596 KB, uploaded 27 February 2018]   |  

Abstract

Three new polyketides, lactomycins A (1)–C (3), were isolated from the culture broth of a marine-derived Streptomyces sp. ACT232 as cathepsin B inhibitors. Their structures were determined by a combination of NMR and MS data analyses to be the dephosphorylated derivatives of a phoslactomycin class of metabolites. Lactomycins exhibited cathepsin B inhibitory activity (IC50 0.8 to 4.5 μg/mL). Even though the biosynthetic gene clusters found in the genome of the current strain have high similarity to those of phoslactomycin, neither phoslactomycins nor leustroducsins were detected by LC-MS analyses of the crude extract. View Full-Text
Keywords: Streptomyces; cathepsin B; enzyme inhibitory; phoslactomycin Streptomyces; cathepsin B; enzyme inhibitory; phoslactomycin
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Share & Cite This Article

MDPI and ACS Style

Sun, Y.; Carandang, R.R.; Harada, Y.; Okada, S.; Yoshitake, K.; Asakawa, S.; Nogi, Y.; Matsunaga, S.; Takada, K. Lactomycins A–C, Dephosphorylated Phoslactomycin Derivatives that Inhibit Cathepsin B, from the Marine-derived Streptomyces sp. ACT232. Mar. Drugs 2018, 16, 70.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top