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Special Issue "Natural Products from Marine Actinomycetes"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 31 January 2018

Special Issue Editors

Guest Editor
Prof. Dr. Dong-Chan Oh

Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea
E-Mail
Interests: marine actinomycetes; natural products; NMR; structure elucidation; antibiotics; symbiosis; biosynthesis; genomics
Guest Editor
Prof. Dr. Sang-Jip Nam

Natural Product and Medicine Research Laboratory, Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Republic of Korea
E-Mail
Interests: marine actinomycetes; natural products; NMR; structure elucidation; mixed-fermentation; marine-organisms associated microbes

Special Issue Information

Dear Colleagues, 

Actinobacteria had been recognized as an important chemical producer of bioactive secondary metabolites in the golden era of anticancer/antibiotic discovery. Unfortunately, the discovery of new bioactive natural products from this promising bacterial group has declined due to redundant studies on heavily investigated terrestrial actinomycetes. However, it has been increasingly highlighted that marine-derived actinomycetes are also very promising sources for discovering new secondary metabolites with pharmaceutical potential.

This Special Issue aims to integrate original research articles regarding studies of natural products from marine-derived actinomycetes including new natural products discovery, chemical biology, new methods for discovering secondary metabolites, structure elucidation, genomic and biosynthetic research of natural products, and new biological activities

Prof. Dr. Dong-Chan Oh
Prof. Dr. Sang-Jip Nam
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine actinomycete
  • natural products
  • secondary metabolite
  • biosynthesis
  • genomics
  • structure elucidation
  • drug discovery

Published Papers (4 papers)

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Research

Open AccessFeature PaperArticle Saccharomonopyrones A–C, New α-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490
Mar. Drugs 2017, 15(8), 239; doi:10.3390/md15080239
Received: 2 June 2017 / Revised: 13 July 2017 / Accepted: 25 July 2017 / Published: 3 August 2017
PDF Full-text (939 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Intensive study of the organic extract of the marine-derived bacterium Saccharomonospora sp. CNQ-490 has yielded three new α-pyrones, saccharomonopyrones A–C (13). The chemical structures of these compounds were assigned from the interpretation of 1D, 2D NMR and mass spectrometry
[...] Read more.
Intensive study of the organic extract of the marine-derived bacterium Saccharomonospora sp. CNQ-490 has yielded three new α-pyrones, saccharomonopyrones A–C (13). The chemical structures of these compounds were assigned from the interpretation of 1D, 2D NMR and mass spectrometry data. Saccharomonopyrone A (1) is the first α-pyrone microbial natural product bearing the ethyl-butyl ether chain in the molecule, while saccharomonopyrones B and C possess unusual 3-methyl and a 6-alkyl side-chain within a 3,4,5,6-tetrasubstituted α-pyrone moiety. Saccharomonopyrone A exhibited weak antioxidant activity using a cation radical scavenging activity assay with an IC50 value of 140 μM. Full article
(This article belongs to the Special Issue Natural Products from Marine Actinomycetes)
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Open AccessFeature PaperArticle Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069
Mar. Drugs 2017, 15(8), 244; doi:10.3390/md15080244
Received: 11 July 2017 / Revised: 11 July 2017 / Accepted: 27 July 2017 / Published: 2 August 2017
PDF Full-text (1773 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Two new alkaloids, strepchazolins A (1) and B (2), together with a previously reported compound, streptazolin (3), were isolated from a marine actinomycete, Streptomyces chartreusis NA02069, collected in the Coast of Hainan Island, China. The structures of
[...] Read more.
Two new alkaloids, strepchazolins A (1) and B (2), together with a previously reported compound, streptazolin (3), were isolated from a marine actinomycete, Streptomyces chartreusis NA02069, collected in the Coast of Hainan Island, China. The structures of new compounds were determined by extensive NMR, mass spectroscopic and X-ray crystallographic analysis, as well as modified Mosher’s method. Compound 1 showed weak anti-Bacillus subtilis activity with the MIC value of 64.0 μM, and weak inhibitory activity against acetylcholinesterase (AChE) in vitro with IC50 value of 50.6 μM, while its diastereoisomer, Compound 2, is almost inactive. Full article
(This article belongs to the Special Issue Natural Products from Marine Actinomycetes)
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Open AccessCommunication Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207
Mar. Drugs 2017, 15(7), 230; doi:10.3390/md15070230
Received: 25 May 2017 / Revised: 30 June 2017 / Accepted: 14 July 2017 / Published: 19 July 2017
Cited by 3 | PDF Full-text (881 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
A novel indole, microindolinone A (1), was isolated from a deep-sea-derived actinomycete Microbacterium sp. MCCC 1A11207, together with 18 known compounds (219). By detailed analysis of the 1H, 13C, HSQC, COSY, HMBC, high resolution electron
[...] Read more.
A novel indole, microindolinone A (1), was isolated from a deep-sea-derived actinomycete Microbacterium sp. MCCC 1A11207, together with 18 known compounds (219). By detailed analysis of the 1H, 13C, HSQC, COSY, HMBC, high resolution electron spray ionization mass spectrum (HRESIMS), and circular dichroism (CD) data, the absolute configuration of 1 was elucidated as 5R-hydroxy-4,5,6,7-tetrahydroindole-4-one. It is noteworthy that 1 is the second example of a saturated indole isolated from nature. Full article
(This article belongs to the Special Issue Natural Products from Marine Actinomycetes)
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Open AccessArticle Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp. M-207 Associated with the Deep-Sea Coral Lophelia pertusa
Mar. Drugs 2017, 15(5), 144; doi:10.3390/md15050144
Received: 24 February 2017 / Revised: 11 May 2017 / Accepted: 15 May 2017 / Published: 19 May 2017
Cited by 1 | PDF Full-text (716 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m
[...] Read more.
The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Avilés Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7). Lobophorin K also displayed moderate and selective antibiotic activity against pathogenic Gram-positive bacteria such as Staphylococcus aureus. Full article
(This article belongs to the Special Issue Natural Products from Marine Actinomycetes)
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