Next Article in Journal
Bifurcatriol, a New Antiprotozoal Acyclic Diterpene from the Brown Alga Bifurcaria bifurcata
Next Article in Special Issue
Saccharomonopyrones A–C, New α-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490
Previous Article in Journal
Isolation and Tissue Distribution of an Insulin-Like Androgenic Gland Hormone (IAG) of the Male Red Deep-Sea Crab, Chaceon quinquedens
Previous Article in Special Issue
Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessFeature PaperArticle
Mar. Drugs 2017, 15(8), 244; doi:10.3390/md15080244

Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069

1
State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210023, China
2
State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
3
Key Laboratory of Biology and Genetic Resources of Tropical Crops of Ministry of Agriculture, Institute of Tropical Biosciences and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Dong-Chan Oh and Sang-Jip Nam
Received: 11 July 2017 / Revised: 11 July 2017 / Accepted: 27 July 2017 / Published: 2 August 2017
(This article belongs to the Special Issue Natural Products from Marine Actinomycetes)
View Full-Text   |   Download PDF [1773 KB, uploaded 2 August 2017]   |  

Abstract

Two new alkaloids, strepchazolins A (1) and B (2), together with a previously reported compound, streptazolin (3), were isolated from a marine actinomycete, Streptomyces chartreusis NA02069, collected in the Coast of Hainan Island, China. The structures of new compounds were determined by extensive NMR, mass spectroscopic and X-ray crystallographic analysis, as well as modified Mosher’s method. Compound 1 showed weak anti-Bacillus subtilis activity with the MIC value of 64.0 μM, and weak inhibitory activity against acetylcholinesterase (AChE) in vitro with IC50 value of 50.6 μM, while its diastereoisomer, Compound 2, is almost inactive. View Full-Text
Keywords: alkaloid; strepchazolin; streptazolin; Streptomyces chartreusis; marine natural product; antimicrobial activity; acetylcholinesterase inhibitory activity alkaloid; strepchazolin; streptazolin; Streptomyces chartreusis; marine natural product; antimicrobial activity; acetylcholinesterase inhibitory activity
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Yang, C.-L.; Wang, Y.-S.; Liu, C.-L.; Zeng, Y.-J.; Cheng, P.; Jiao, R.-H.; Bao, S.-X.; Huang, H.-Q.; Tan, R.-X.; Ge, H.-M. Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069. Mar. Drugs 2017, 15, 244.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top