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Molecules, Volume 10, Issue 12 (December 2005), Pages 1429-1461

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Research

Open AccessArticle Synthesis of Novel, Potentially Biologically Active Dibenzosuberone Derivatives
Molecules 2005, 10(12), 1429-1437; doi:10.3390/10121429
Received: 10 June 2005 / Revised: 6 September 2005 / Accepted: 7 September 2005 / Published: 31 December 2005
Cited by 9 | PDF Full-text (179 KB) | HTML Full-text | XML Full-text
Abstract Novel representatives of the important group of biologically active dibenzosuberone derivatives were prepared: 3,7-dibromo-5-(dimethylaminoethyl- oxyimino)-10,11-dihydro-5H-dibenzo[a,d]cyclohepta-1,4-diene (1), 3,7-dibromo-5-(3- dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (2) and 1,7- dibromo-5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo-[a,d]-cycloheptene (3). These compounds are potential tricyclic antidepressants (TCAs), which are still the most frequently prescribed antidepressants in many countries. Full article
Open AccessArticle An Efficient Protocol for the Solid-phase Synthesis of Malondiamides
Molecules 2005, 10(12), 1438-1445; doi:10.3390/10121438
Received: 5 August 2005 / Revised: 18 October 2005 / Accepted: 20 October 2005 / Published: 31 December 2005
PDF Full-text (131 KB) | HTML Full-text | XML Full-text
Abstract A novel and straightforward solid-phase synthesis of malondiamides containing a free nitrogen has been developed. These intermediates, which can be directly obtained in good yield and purity, can be further derivatised. This approach can be used for the synthesis of large split-and-mix-libraries. Full article
Open AccessArticle Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues
Molecules 2005, 10(12), 1446-1457; doi:10.3390/10121446
Received: 30 August 2005 / Revised: 21 October 2005 / Accepted: 15 November 2005 / Published: 31 December 2005
Cited by 9 | PDF Full-text (143 KB) | HTML Full-text | XML Full-text
Abstract Aryl free-radicals generated at the C-7 position of ethyl indole-2-carboxylates bearing N-allyl and propargylic groups triggered intramolecular cyclizations to furnish a new class of Duocarmycin analogues, formal ethyl pyrrolo[3,2,1-ij]quinoline-2- carboxylate derivatives, through the less favorable 6-endo-trig cyclization mode. Full article
Open AccessArticle Chromate Oxidation of α-Nitro Alcohols to α-Nitro Ketones: Significant Improvements to a Classic Method
Molecules 2005, 10(12), 1458-1461; doi:10.3390/10121458
Received: 12 September 2005 / Accepted: 8 October 2005 / Published: 31 December 2005
Cited by 5 | PDF Full-text (36 KB) | HTML Full-text | XML Full-text
Abstract
A series of eight alkyl and aryl α-nitro ketones were prepared by the potassium dichromate oxidation of the corresponding nitro alcohols. Short reaction times allowed for the easy isolation of pure nitro ketones that are devoid of starting materials and/or other oxidation side
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A series of eight alkyl and aryl α-nitro ketones were prepared by the potassium dichromate oxidation of the corresponding nitro alcohols. Short reaction times allowed for the easy isolation of pure nitro ketones that are devoid of starting materials and/or other oxidation side products. Full article

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