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Molecules 2005, 10(12), 1438-1445; doi:10.3390/10121438

An Efficient Protocol for the Solid-phase Synthesis of Malondiamides

Novartis Institutes for BioMedical Research, WSJ-507, CH-4002 Basel, Switzerland
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Received: 5 August 2005 / Revised: 18 October 2005 / Accepted: 20 October 2005 / Published: 31 December 2005
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Abstract

A novel and straightforward solid-phase synthesis of malondiamides containing a free nitrogen has been developed. These intermediates, which can be directly obtained in good yield and purity, can be further derivatised. This approach can be used for the synthesis of large split-and-mix-libraries. View Full-Text
Keywords: Combinatorial chemistry – Solid-phase synthesis – Amides – Acylations – Peptides. Combinatorial chemistry – Solid-phase synthesis – Amides – Acylations – Peptides.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Vögtle, M.M.; Marzinzik, A.L. An Efficient Protocol for the Solid-phase Synthesis of Malondiamides. Molecules 2005, 10, 1438-1445.

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