An Efficient Protocol for the Solid-phase Synthesis of Malondiamides

doi:10.3390/10121438

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Molecules 2005, 10(12), 1438-1445; doi:10.3390/10121438

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An Efficient Protocol for the Solid-phase Synthesis of Malondiamides

Markus M. Vögtle and Andreas L. Marzinzik*

Novartis Institutes for BioMedical Research, WSJ-507, CH-4002 Basel, Switzerland

* Author to whom correspondence should be addressed.

Received: 5 August 2005; in revised form: 18 October 2005 / Accepted: 20 October 2005 / Published: 31 December 2005

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Abstract: A novel and straightforward solid-phase synthesis of malondiamides containing a free nitrogen has been developed. These intermediates, which can be directly obtained in good yield and purity, can be further derivatised. This approach can be used for the synthesis of large split-and-mix-libraries.

Keywords: Combinatorial chemistry – Solid-phase synthesis – Amides – Acylations – Peptides.

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MDPI and ACS Style

Vögtle, M.M.; Marzinzik, A.L. An Efficient Protocol for the Solid-phase Synthesis of Malondiamides. Molecules 2005, 10, 1438-1445.

AMA Style

Vögtle MM, Marzinzik AL. An Efficient Protocol for the Solid-phase Synthesis of Malondiamides. Molecules. 2005; 10(12):1438-1445.

Chicago/Turabian Style

Vögtle, Markus M.; Marzinzik, Andreas L. 2005. "An Efficient Protocol for the Solid-phase Synthesis of Malondiamides." Molecules 10, no. 12: 1438-1445.

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