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Molecules 2005, 10(12), 1429-1437; doi:10.3390/10121429

Synthesis of Novel, Potentially Biologically Active Dibenzosuberone Derivatives

Belupo Pharmaceuticals & Cosmetics Ltd., Radnicka 224, 10000 Zagreb, Croatia
Ruder Boskovic Institute, Bijenicka 54, 10002 Zagreb, Croatia
Author to whom correspondence should be addressed.
Received: 10 June 2005 / Revised: 6 September 2005 / Accepted: 7 September 2005 / Published: 31 December 2005
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Novel representatives of the important group of biologically active dibenzosuberone derivatives were prepared: 3,7-dibromo-5-(dimethylaminoethyl- oxyimino)-10,11-dihydro-5H-dibenzo[a,d]cyclohepta-1,4-diene (1), 3,7-dibromo-5-(3- dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (2) and 1,7- dibromo-5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo-[a,d]-cycloheptene (3). These compounds are potential tricyclic antidepressants (TCAs), which are still the most frequently prescribed antidepressants in many countries. View Full-Text
Keywords: Dibenzosuberone; tricyclic antidepressants; bromination; amitriptiline; noxiptiline Dibenzosuberone; tricyclic antidepressants; bromination; amitriptiline; noxiptiline

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MDPI and ACS Style

Merkas, S.; Litvic, M.; Cepanec, I.; Vinkovic, V. Synthesis of Novel, Potentially Biologically Active Dibenzosuberone Derivatives. Molecules 2005, 10, 1429-1437.

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