Molecules 2005, 10(12), 1446-1457; doi:10.3390/10121446
Article

Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues

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Received: 30 August 2005; in revised form: 21 October 2005 / Accepted: 15 November 2005 / Published: 31 December 2005
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Aryl free-radicals generated at the C-7 position of ethyl indole-2-carboxylates bearing N-allyl and propargylic groups triggered intramolecular cyclizations to furnish a new class of Duocarmycin analogues, formal ethyl pyrrolo[3,2,1-ij]quinoline-2- carboxylate derivatives, through the less favorable 6-endo-trig cyclization mode.
Keywords: Duocarmycin; free-radicals; intramolecular cyclization; indole; pyrroloquinoline
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MDPI and ACS Style

Al-Said, N.H.; Shawakfeh, K.Q.; Abdullah, W.N. Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues. Molecules 2005, 10, 1446-1457.

AMA Style

Al-Said NH, Shawakfeh KQ, Abdullah WN. Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues. Molecules. 2005; 10(12):1446-1457.

Chicago/Turabian Style

Al-Said, Naim H.; Shawakfeh, Khaled Q.; Abdullah, Wasim N. 2005. "Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues." Molecules 10, no. 12: 1446-1457.

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