Special Issue "Renal Toxicity"
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: closed (30 June 2010)
Dr. Susan A. Elmore
NTP Pathologist and Staff Scientist, COTR, NTP Pathology Support Contracts, National Institute of Environmental Health Sciences, Cellular and Molecular Pathology Branch, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA
Phone: +1 919 541 3474
Fax: +1 919 541 7666
A wide variety of drugs and environmental chemicals are known to cause nephrotoxicity. The mammalian kidney is particularly susceptible to the toxic effects of noxious chemicals, in part, due to the unique physiologic and anatomic features of this organ. The excretory and metabolic functions of the kidneys place them at high risk following exposure to toxicants. Xenobiotics in the systemic circulation are delivered to the kidney in relatively high amounts because this organ receives about 25% of the resting cardiac output. Toxicants are also concentrated in the tubular fluid via the normal processes of urine concentration. For this reason, a nontoxic plasma concentration may achieve toxic concentrations within the kidney. Furthermore, the biotransformation of xenobiotics to toxic intermediates within the tubular epithelium also contributes to this increased renal susceptibility to toxic injury. Over the past decade, research into the pathophysiologic and molecular basis of renal disease has grown tremendously with the ultimate goal of assessing human health risk. This special journal issue provides a review of mechanisms of acute renal failure with examples of renal toxicity from a variety of agents including mycotoxins, herbicides, heavy metals, solvents, therapeutic agents and plants. Chemically induced α2u-globulin nephropathy is also reviewed.
Dr. Susan A. Elmore
Toxins 2010, 2(11), 2490-2518; doi:10.3390/toxins2112490
Received: 14 September 2010; in revised form: 14 October 2010 / Accepted: 22 October 2010 / Published: 26 October 2010| Cited by 76 | PDF Full-text (657 KB) | HTML Full-text | XML Full-text
Toxins 2010, 2(10), 2340-2358; doi:10.3390/toxins2102340
Received: 27 August 2010; in revised form: 23 September 2010 / Accepted: 26 September 2010 / Published: 11 October 2010| Cited by 4 | PDF Full-text (136 KB) | HTML Full-text | XML Full-text
Toxins 2010, 2(8), 2055-2082; doi:10.3390/toxins2082055
Received: 1 July 2010; in revised form: 5 August 2010 / Accepted: 5 August 2010 / Published: 9 August 2010| Cited by 6 | PDF Full-text (173 KB) | HTML Full-text | XML Full-text
Article: Contrasting Nephropathic Responses to Oral Administration of Extract of Cultured Penicillium polonicum in Rat and Primate
Toxins 2010, 2(8), 2083-2097; doi:10.3390/toxins2082083
Received: 23 June 2010; in revised form: 29 July 2010 / Accepted: 5 August 2010 / Published: 9 August 2010| Cited by 2 | PDF Full-text (534 KB) | HTML Full-text | XML Full-text
Last update: 5 March 2014