Special Issue "Renal Toxicity"

Guest Editor
Dr. Susan A. Elmore
NTP Pathologist and Staff Scientist, COTR, NTP Pathology Support Contracts, National Institute of Environmental Health Sciences, Cellular and Molecular Pathology Branch, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA
E-Mail: elmore@niehs.nih.gov
Phone: +1 919 541 3474
Fax: +1 919 541 7666

Dear Colleagues,

A wide variety of drugs and environmental chemicals are known to cause nephrotoxicity. The mammalian kidney is particularly susceptible to the toxic effects of noxious chemicals, in part, due to the unique physiologic and anatomic features of this organ. The excretory and metabolic functions of the kidneys place them at high risk following exposure to toxicants. Xenobiotics in the systemic circulation are delivered to the kidney in relatively high amounts because this organ receives about 25% of the resting cardiac output. Toxicants are also concentrated in the tubular fluid via the normal processes of urine concentration. For this reason, a nontoxic plasma concentration may achieve toxic concentrations within the kidney. Furthermore, the biotransformation of xenobiotics to toxic intermediates within the tubular epithelium also contributes to this increased renal susceptibility to toxic injury. Over the past decade, research into the pathophysiologic and molecular basis of renal disease has grown tremendously with the ultimate goal of assessing human health risk. This special journal issue provides a review of mechanisms of acute renal failure with examples of renal toxicity from a variety of agents including mycotoxins, herbicides, heavy metals, solvents, therapeutic agents and plants. Chemically induced α2u-globulin nephropathy is also reviewed.

Dr. Susan A. Elmore
Guest Editor

Submission

All manuscripts should be submitted to toxins@mdpi.com with a copy to the Guest Editor. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed Open Access monthly journal published by MDPI.

• nephrotoxicity
• renal
• xenobiotic
• biotransformation
• α2u-globulin