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Genomic Damage in Endstage Renal Disease—Contribution of Uremic Toxins
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Toxins 2010, 2(11), 2490-2518; doi:10.3390/toxins2112490

Mechanisms of Cisplatin Nephrotoxicity

Division of Nephrology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Author to whom correspondence should be addressed.
Received: 14 September 2010 / Revised: 14 October 2010 / Accepted: 22 October 2010 / Published: 26 October 2010
(This article belongs to the Special Issue Renal Toxicity)
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Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatin-induced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention. View Full-Text
Keywords: cisplatin; inflammation; kidney injury; nephrotoxicity; apoptosis; dendritic cells; cytokines; toll-like receptors cisplatin; inflammation; kidney injury; nephrotoxicity; apoptosis; dendritic cells; cytokines; toll-like receptors

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Miller, R.P.; Tadagavadi, R.K.; Ramesh, G.; Reeves, W.B. Mechanisms of Cisplatin Nephrotoxicity. Toxins 2010, 2, 2490-2518.

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