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Genomic Damage in Endstage Renal Disease—Contribution of Uremic Toxins
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Toxins 2010, 2(11), 2490-2518; doi:10.3390/toxins2112490

Mechanisms of Cisplatin Nephrotoxicity

Division of Nephrology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
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Received: 14 September 2010 / Revised: 14 October 2010 / Accepted: 22 October 2010 / Published: 26 October 2010
(This article belongs to the Special Issue Renal Toxicity)
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Abstract

Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatin-induced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.
Keywords: cisplatin; inflammation; kidney injury; nephrotoxicity; apoptosis; dendritic cells; cytokines; toll-like receptors cisplatin; inflammation; kidney injury; nephrotoxicity; apoptosis; dendritic cells; cytokines; toll-like receptors
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Miller, R.P.; Tadagavadi, R.K.; Ramesh, G.; Reeves, W.B. Mechanisms of Cisplatin Nephrotoxicity. Toxins 2010, 2, 2490-2518.

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