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Mechanisms of Cisplatin Nephrotoxicity
Division of Nephrology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
* Author to whom correspondence should be addressed.
Received: 14 September 2010; in revised form: 14 October 2010 / Accepted: 22 October 2010 / Published: 26 October 2010
Abstract: Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatin-induced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.
Keywords: cisplatin; inflammation; kidney injury; nephrotoxicity; apoptosis; dendritic cells; cytokines; toll-like receptors
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Miller, R.P.; Tadagavadi, R.K.; Ramesh, G.; Reeves, W.B. Mechanisms of Cisplatin Nephrotoxicity. Toxins 2010, 2, 2490-2518.
Miller RP, Tadagavadi RK, Ramesh G, Reeves WB. Mechanisms of Cisplatin Nephrotoxicity. Toxins. 2010; 2(11):2490-2518.
Miller, Ronald P.; Tadagavadi, Raghu K.; Ramesh, Ganesan; Reeves, William Brian. 2010. "Mechanisms of Cisplatin Nephrotoxicity." Toxins 2, no. 11: 2490-2518.