Toxins 2010, 2(11), 2490-2518; doi:10.3390/toxins2112490
Mechanisms of Cisplatin Nephrotoxicity
Division of Nephrology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
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Received: 14 September 2010 / Revised: 14 October 2010 / Accepted: 22 October 2010 / Published: 26 October 2010
(This article belongs to the Special Issue Renal Toxicity)
Abstract
Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatin-induced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.Keywords:
cisplatin; inflammation; kidney injury; nephrotoxicity; apoptosis; dendritic cells; cytokines; toll-like receptors
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MDPI and ACS Style
Miller, R.P.; Tadagavadi, R.K.; Ramesh, G.; Reeves, W.B. Mechanisms of Cisplatin Nephrotoxicity. Toxins 2010, 2, 2490-2518.