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Toxins 2010, 2(8), 2083-2097; doi:10.3390/toxins2082083
Article

Contrasting Nephropathic Responses to Oral Administration of Extract of Cultured Penicillium polonicum in Rat and Primate

1,* , 1
 and 2
Received: 23 June 2010; in revised form: 29 July 2010 / Accepted: 5 August 2010 / Published: 9 August 2010
(This article belongs to the Special Issue Renal Toxicity)
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Abstract: Liquid- or solid substrate-cultured Penicillium polonicum administered in feed to rats over several days evokes a histopathological response in kidney involving apoptosis and abnormal mitosis in proximal tubules. The amphoteric toxin is yet only partly characterized, but can be isolated from cultured sporulating biomass in a fraction that is soluble in water and ethanol, and exchangeable on either anion- or cation-exchange resins. After several weeks of treatment renal proximal tubule distortion became striking on account of karyocytomegaly, but even treatment for nearly two years remained asymptomatic. Extract from a batch of solid substrate fermentation of P. polonicum on shredded wheat was incorporated into feed for rats during four consecutive days, and also given as an aqueous solution by oral gavage to a vervet monkey daily for 10 days. Treatment was asymptomatic for both types of animal. Rat response was evident as the typical renal apoptosis and karyomegaly. In contrast there was no such response in the primate; and neither creatinine clearance nor any haematological characteristic or serum component concentration deviated from a control or from historical data for this primate. The contrast is discussed concerning other negative findings for P. polonicum in pigs and hamsters. Renal karyomegaly, as a common rat response to persistent exposure to ochratoxin A, is not known in humans suspected as being exposed to more than the usual trace amounts of dietary ochratoxin A. Therefore the present findings question assumptions that human response to ochratoxin A conforms to that in the rat.
Keywords: karyomegaly; karyocytomegaly; porcine nephropathy; Penicillium polonicum; ochratoxin A; mycotoxin; vervet monkey; rat renal pathology karyomegaly; karyocytomegaly; porcine nephropathy; Penicillium polonicum; ochratoxin A; mycotoxin; vervet monkey; rat renal pathology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Mantle, P.G.; McHugh, K.M.; Fincham, J.E. Contrasting Nephropathic Responses to Oral Administration of Extract of Cultured Penicillium polonicum in Rat and Primate. Toxins 2010, 2, 2083-2097.

AMA Style

Mantle PG, McHugh KM, Fincham JE. Contrasting Nephropathic Responses to Oral Administration of Extract of Cultured Penicillium polonicum in Rat and Primate. Toxins. 2010; 2(8):2083-2097.

Chicago/Turabian Style

Mantle, Peter G.; McHugh, Katharine M.; Fincham, John E. 2010. "Contrasting Nephropathic Responses to Oral Administration of Extract of Cultured Penicillium polonicum in Rat and Primate." Toxins 2, no. 8: 2083-2097.



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