Special Issue "The Intestine and Uremia"
Deadline for manuscript submissions: closed (30 June 2018)
Prof. Dr. Griet Glorieux
Department of Internal Medicine, Nephrology Division, Ghent University Hospital, 9000 Ghent, Belgium
Interests: Uremic toxins; Protein binding; Chronic kidney disease; Leukocyte/monocyte function; Leukocyte-Endothelial interaction; Inflammation in CKD; Dialysis fluid purity/endotoxin; Gut-kidney axis
The interaction between the host and the intestinal microbiota has recently been a focus of increasing interest. In chronic kidney disease (CKD), the interaction is bidirectional, while uremia affects both the composition and the metabolism of the intestinal microbiota, important uremic toxins are generated by the microbial metabolism. In addition, intestinal dysbiosis leads to a disruption of the intestinal barrier function, contributing to inflammation. The predominant proteolytic fermentation pattern in CKD contributes to the generation of well-known uremic toxins, such as indoxyl sulfate and p-cresyl sulfate, both end-products of protein fermentation, of which the cardiovascular and renal toxicity has been demonstrated extensively in in vitro, in vivo (animal) and clinical studies. In order to be able to target these, and other, intestinally generated toxins, a better characterization of the intestinal microbial profile in CKD is needed. Unfortunately, the CKD population is characterized by many confounding factors in this context such as dietary restriction, increased age, increased transit time, intake of medication in general and antibiotics in specific, limited exercise, diabetes mellitus, etc. The focus of this Special Issue of Toxins will be on the gut-kidney axis in all its aspects: intestinal microbiome profiling, intestinally generated uremic toxins, confounding factors for a CKD population, possible interventions trying to decrease generation of toxins and this with the aim to decrease inflammation and to improve outcome of CKD patients.Prof. Dr. Griet Glorieux
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Gut-kidney axis
- Intestinal microbiota
- Uremic toxins
- Chronic kidney disease (CKD)
- Confounders in CKD (old age, constipation, diabetes, medication (antibiotics), limited exercise,…)
- Intestinal barrier
- Intervention (pre-, pro-, synbiotics)