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Toxins 2018, 10(4), 155; https://doi.org/10.3390/toxins10040155

The Role of Gut Microbiota and Diet on Uremic Retention Solutes Production in the Context of Chronic Kidney Disease

1
Department Nephrology, Centre Hospitalier Lyon Sud, F-69495 Pierre-Benite, France
2
CarMeN Lab, INSA-Lyon, INSERM U1060, INRA, University Lyon 1, F-69621 Villeurbanne, France
*
Author to whom correspondence should be addressed.
Received: 26 March 2018 / Revised: 9 April 2018 / Accepted: 11 April 2018 / Published: 13 April 2018
(This article belongs to the Special Issue The Intestine and Uremia)
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Abstract

Uremic retention solutes (URS) are associated with cardiovascular complications and poor survival in chronic kidney disease. The better understanding of the origin of a certain number of these toxins enabled the development of new strategies to reduce their production. URS can be classified according to their origins (i.e., host, microbial, or exogenous). The discovery of the fundamental role that the intestinal microbiota plays in the production of many URS has reinstated nutrition at the heart of therapeutics to prevent the accumulation of URS and their deleterious effects. The intestinal microbiota is personalized and is strongly influenced by dietary habits, such as the quantity and the quality of dietary protein and fibers. Herein, this review out lines the role of intestinal microbiota on URS production and the recent discoveries on the effect of diet composition on the microbial balance in the host with a focus on the effect on URS production. View Full-Text
Keywords: chronic kidney disease; intestinal microbiota; pro/prebiotics; vegetarian diet; low protein diet; nutrient composition; uremic toxins chronic kidney disease; intestinal microbiota; pro/prebiotics; vegetarian diet; low protein diet; nutrient composition; uremic toxins
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Koppe, L.; Fouque, D.; Soulage, C.O. The Role of Gut Microbiota and Diet on Uremic Retention Solutes Production in the Context of Chronic Kidney Disease. Toxins 2018, 10, 155.

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