Special Issue "Enterotoxins: Microbial Proteins and Host Cell Dysregulation"
Deadline for manuscript submissions: closed (31 January 2015)
Dr. Teresa Krakauer
Department of Immunology, Integrated Toxicology Division, United States Army Medical Research, Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA
Phone: +1 301 619 4733
Fax: +1 301 619 2348
Enterotoxins encompass a diverse group of microbial toxins affecting the gut and are major contributors to bacterial food borne illness, gastrointestinal and systemic diseases for which limited therapeutics are available. Although the pathogenic effects arise from mucosal perturbation, dysregulation of immune cells through mediator release, cell activation or damage are major factors disrupting homeostasis in gut mucosa. Whereas proinflammatory cytokines and chemokines mediate toxic shock induced by staphylococcal enterotoxins, apoptosis and cytotoxic events are responsible for Clostridium perfringens enterotoxin and cholera toxin. Understanding of receptors, signaling pathways and the communication between cells of the gastrointestinal tract, immune and neuroendocrine system will facilitate the development of new therapeutics.
Dr. Teresa Krakauer
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed Open Access monthly journal published by MDPI.Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs).
- receptor and signaling mechanism
- mucosal perturbation
- targeted therapeutics