Special Issue "Enterotoxins: Microbial Proteins and Host Cell Dysregulation"


A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: 31 January 2015

Special Issue Editor

Guest Editor
Dr. Teresa Krakauer
Department of Immunology, Integrated Toxicology Division, United States Army Medical Research, Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA
E-Mail: teresa.krakauer@us.army.mil
Phone: +1 301 619 4733
Fax: +1 301 619 2348

Special Issue Information

Dear Colleagues,

Enterotoxins encompass a diverse group of microbial toxins affecting the gut and are major contributors to bacterial food borne illness, gastrointestinal and systemic diseases for which limited therapeutics are available. Although the pathogenic effects arise from mucosal perturbation, dysregulation of immune cells through mediator release, cell activation or damage are major factors disrupting homeostasis in gut mucosa. Whereas proinflammatory cytokines and chemokines mediate toxic shock induced by staphylococcal enterotoxins, apoptosis and cytotoxic events are responsible for Clostridium perfringens enterotoxin and cholera toxin. Understanding of receptors, signaling pathways and the communication between cells of the gastrointestinal tract, immune and neuroendocrine system will facilitate the development of new therapeutics.

Dr. Teresa Krakauer
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs).


  • enterotoxins
  • receptor and signaling mechanism
  • mucosal perturbation
  • immunoregulation
  • targeted therapeutics

Published Papers (8 papers)

by , , , , , ,  and
Toxins 2014, 6(7), 2162-2176; doi:10.3390/toxins6072162
Received: 22 April 2014; in revised form: 3 July 2014 / Accepted: 4 July 2014 / Published: 22 July 2014
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by , , , ,  and
Toxins 2014, 6(6), 1724-1741; doi:10.3390/toxins6061724
Received: 6 February 2014; in revised form: 7 May 2014 / Accepted: 20 May 2014 / Published: 30 May 2014
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by  and
Toxins 2014, 6(5), 1471-1489; doi:10.3390/toxins6051471
Received: 18 December 2013; in revised form: 18 April 2014 / Accepted: 22 April 2014 / Published: 25 April 2014
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abstract graphic

by ,  and
Toxins 2014, 6(2), 556-574; doi:10.3390/toxins6020556
Received: 16 December 2013; in revised form: 21 January 2014 / Accepted: 22 January 2014 / Published: 28 January 2014
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by , ,  and
Toxins 2013, 5(11), 2138-2160; doi:10.3390/toxins5112138
Received: 1 October 2013; in revised form: 30 October 2013 / Accepted: 31 October 2013 / Published: 12 November 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (334 KB) | HTML Full-text | XML Full-text

by  and
Toxins 2013, 5(10), 1859-1871; doi:10.3390/toxins5101859
Received: 8 August 2013; in revised form: 9 October 2013 / Accepted: 10 October 2013 / Published: 22 October 2013
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by ,  and
Toxins 2013, 5(10), 1814-1826; doi:10.3390/toxins5101814
Received: 14 August 2013; in revised form: 3 October 2013 / Accepted: 12 October 2013 / Published: 17 October 2013
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Toxins 2013, 5(9), 1629-1654; doi:10.3390/toxins5091629
Received: 8 July 2013; in revised form: 13 September 2013 / Accepted: 13 September 2013 / Published: 24 September 2013
Show/Hide Abstract | Cited by 2 | PDF Full-text (476 KB) | HTML Full-text | XML Full-text

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of Paper: Review

Title: Redox Regulation of Toxinogenesis by Bacillus cereus
Catherine Duport 1,2,* and Thierry Clavel 1,2
1 Université d’Avignon et des Pays de Vaucluse, UMR408, Sécurité et Qualité des Produits d’Origine Végétale, F-84000 Avignon, France
INRA, UMR408, Sécurité et Qualité des Produits d’Origine végétale, F-84914 Avignon, France
*   Author to whom correspondence should be addressed; E-Mail: duport@avignon.inra.fr
Redox reactions are central to both catabolic and anabolic metabolism. The ability to maintain redox balance is thus vital to all pathogens. Various regulatory sensors continually monitor the redox state of the internal and external environments and control the pathways that regulate redox homeostasis. This review focuses on how key redox-dependent transcription factors and signal-transduction pathways control both catabolism and enterotoxin synthesis in Bacillus cereus. The current understanding of how disturbance in redox homeostasis may affect toxinogenesis and contribute to the development of pathogenesis is reviewed. We also discuss how the knowledge on redox regulation of catabolism can be used to predict the diarrheal potential of a B. cereus strain, which is essentially dictated by the amount of secreted nonhemolytic enterotoxin Nhe.

Last update: 16 June 2014

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