Special Issue "Cytotoxic Necrotizing Factors"


A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: closed (31 October 2013)

Special Issue Editor

Guest Editor
Prof. Dr. Alessia Fabbri

Reparto Sostanze Naturali, Medicina Tradizionale, Dipartimento del Farmaco, Viale Regina Elena, 299, 00161 Roma, Italy
Phone: 0039-06-49902939

Special Issue Information

Dear Colleagues,

The cytotoxic necrotising factor (CNF) family of proteins includes bacterial cytotoxic necrotizing factors proteins from Escherichia coli and the related dermonecrotic toxin from Bordetella species. Very recently, also Yersinia pseudotubercolosis have been reported to produce a CNF. These toxins are single chain polypeptides consisting of an N-terminal domain responsible for binding to target cells and a C-terminal domain responsible for the catalytic activity. CNFs and DNT act on the small GTPases of the Rho family through deamidation and/or transglutamination of a Gln residue of the active site, which results in activation of the G proteins and their cognate downstream signaling pathways. In particular, CNFs deamidate Gln63 of Rho or the corresponding Gln61 of Rac and Cdc42 whereas DNT deamidates or polyaminates the Glns with ubiquitous polyamines such as spermine, putresceine and spermidine.

The mechanism of action of CNFs and DNT is now well defined. However, several questions remain as to secretion from bacteria, receptors and translocation into the cytosol.

This special issue aims to provide the state of the art in the research on CNFs and, thus, it will deal with major achievements and recent discoveries on CNFs including three-dimensional structures, activities, toxin receptors, toxin trafficking and clinical applications.

Prof. Dr. Alessia Fabbri
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs).


  • Exotoxin
  • virulence factor
  • Rho GTPase
  • Escherichia coli
  • Bordetella sp.
  • Yersinia pseudotubercolosis

Published Papers (3 papers)

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Displaying article 1-3
p. 270-282
by , , ,  and
Toxins 2014, 6(1), 270-282; doi:10.3390/toxins6010270
Received: 31 October 2013 / Revised: 17 December 2013 / Accepted: 31 December 2013 / Published: 7 January 2014
Show/Hide Abstract | Cited by 3 | PDF Full-text (1168 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Cytotoxic Necrotizing Factors)
p. 2270-2280
by  and
Toxins 2013, 5(11), 2270-2280; doi:10.3390/toxins5112270
Received: 1 October 2013 / Revised: 13 November 2013 / Accepted: 18 November 2013 / Published: 22 November 2013
Show/Hide Abstract | Cited by 2 | PDF Full-text (413 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Cytotoxic Necrotizing Factors)
p. 2241-2257
by , , , , , ,  and
Toxins 2013, 5(11), 2241-2257; doi:10.3390/toxins5112241
Received: 4 September 2013 / Revised: 1 November 2013 / Accepted: 5 November 2013 / Published: 21 November 2013
Show/Hide Abstract | Cited by 6 | PDF Full-text (1447 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Cytotoxic Necrotizing Factors)
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Last update: 9 December 2013

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