Toxins 2014, 6(1), 270-282; doi:10.3390/toxins6010270
Article

The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases

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Received: 31 October 2013; in revised form: 17 December 2013 / Accepted: 31 December 2013 / Published: 7 January 2014
(This article belongs to the Special Issue Cytotoxic Necrotizing Factors)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The Cytotoxic Necrotizing Factor 1 (CNF1), a protein toxin from pathogenic E. coli, modulates the Rho GTPases, thus, directing the organization of the actin cytoskeleton. In the nervous system, the Rho GTPases play a key role in several processes, controlling the morphogenesis of dendritic spines and synaptic plasticity in brain tissues. This review is focused on the peculiar property of CNF1 to enhance brain plasticity in in vivo animal models of central nervous system (CNS) diseases, and on its possible application in therapy.
Keywords: CNF1; actin cytoskeleton; synaptic plasticity; Rho GTPases
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MDPI and ACS Style

Travaglione, S.; Loizzo, S.; Ballan, G.; Fiorentini, C.; Fabbri, A. The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases. Toxins 2014, 6, 270-282.

AMA Style

Travaglione S, Loizzo S, Ballan G, Fiorentini C, Fabbri A. The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases. Toxins. 2014; 6(1):270-282.

Chicago/Turabian Style

Travaglione, Sara; Loizzo, Stefano; Ballan, Giulia; Fiorentini, Carla; Fabbri, Alessia. 2014. "The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases." Toxins 6, no. 1: 270-282.

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