Special Issue "Effects of Mixtures on Ecosystems"


A special issue of Toxics (ISSN 2305-6304).

Deadline for manuscript submissions: closed (30 June 2015)

Special Issue Editor

Guest Editor
Prof. Dr. Marco Vighi

University of Milano-Bicocca, Department of Earth and Environmental Sciences (DISAT), P.za della Scienza 1, I-20126 Milano, Italy
Website: http://www-3.unipv.it/reumatologia-tossicologia/master-rischio-tossicologico/docenti/index.html?load=1&pag=http://www-3.unipv.it/reumatologia-tossicologia/master-rischio-tossicologico/docenti/schede-individuali/marco-vighi.htmhttp://www-3.unipv.it/reumato
Phone: +390264482741
Interests: ecotoxicology; ecological risk assessment; persistent organic pollutants; effects of mixtures on ecosystems

Special Issue Information

Dear Colleagues,

Ecosystems are never exposed to individual chemicals; they are usually exposed to a variety of potentially toxic chemicals, the composition of which is highly variable in space and time.

The presence of mixtures in the environment is due to different kinds of emission patterns, for example:

•        chemicals used as technical mixtures, such as the formulations of plant protection products or other types of commercial products;

•        chemicals emitted by a given human activity, such as an industrial typology or an agricultural crop;

•        chemicals likely to be present in the environment as a result of multiple emissions derived from all human activities present in a given territory.

Nevertheless, chemicals legislation, in all parts of the world, is based predominantly on assessments carried out on individual substances.

In the last few decades, sound scientific bases have been produced for developing tools for Ecological Risk Assessment (ERA) and for proposing regulatory tools for mixtures. An important document on this issue has recently been published by the European Commission (DG SANCO, 2012).

However, a number of knowledge gaps can already be seen, both on exposure and effect, when assessing mixtures. These include the prediction of interactions (synergism and antagonism); the problem of modes on action, if complex biological communities are exposed; and many others.

The scope of this Special Issue is to bring together experimental and predictive approaches for assessing exposure and effects of mixtures on ecosystems, in order to update current knowledge on ERA for mixtures.

Professor Dr. Marco Vighi
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


  • mixtures
  • exposure assessment
  • effect assessment
  • ecological Risk Assessment
  • synergism

Published Papers (1 paper)

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p. 342-369
by , , ,  and
Toxics 2015, 3(4), 342-369; doi:10.3390/toxics3040342
Received: 29 June 2015 / Revised: 9 September 2015 / Accepted: 23 September 2015 / Published: 25 September 2015
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Last update: 12 December 2014

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