Topical Collection "Heavy Metals Toxicology"


A topical collection in Toxics (ISSN 2305-6304).


Collection Editor
Prof. Dr. Wayne Briner
Department of Psychology, Ashford University, 8620 Spectrum Center Blvd, San Diego, CA 92123 USA
Phone: 858-705-2294
Interests: neurotoxicology; heavy metals; teratology; behavioral teratology

Topical Collection Information

Dear Colleagues,

Heavy metals such as lead and mercury continue to effect human and environmental health. Heavy metals not only persist in the environment but continue to be produced and released by mining, manufacturing and environmental processes. Human exposure persists and even expands as humankind develops more manufacturing and mining processes, encroaches on more land area, and develops uses for a wider variety of heavy metals. Progress has been made in understanding the toxicology of metals, prevention has been improved and treatment refined over the years.  Despite these advances more research needs to be done.

We invite contributors to this collection of Toxics that will focus on heavy metal toxicology. We invite all papers addressing this problem.  Theoretical papers will also be considered. We especially encourage papers examining metal-metal interactions and pharmacologic treatment of heavy metal exposure.

Professor Dr. Wayne Briner
Collection Editor

Manuscript Submission Information

Manuscripts for the topical collection can be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on this website. The topical collection considers regular research articles, short communications and review articles. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.

Please visit the Instructions for Authors page before submitting a manuscript. For the first few issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


  • heavy metal
  • interactions
  • chelation
  • lead
  • mercury
  • treatment
  • molecular mechanisms
  • antagonist

Published Papers (8 papers)

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2015  ( 2 papers )

2014  ( 6 papers )

Toxics 2015, 3(2), 170-186; doi:10.3390/toxics3020170
Received: 16 March 2015 / Revised: 8 April 2015 / Accepted: 22 April 2015 / Published: 28 April 2015
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by  and
Toxics 2015, 3(2), 130-151; doi:10.3390/toxics3020130
Received: 15 March 2015 / Revised: 30 March 2015 / Accepted: 3 April 2015 / Published: 13 April 2015
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by , , , , ,  and
Toxics 2014, 2(3), 417-442; doi:10.3390/toxics2030417
Received: 3 March 2014 / Revised: 21 July 2014 / Accepted: 6 August 2014 / Published: 18 August 2014
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by ,  and
Toxics 2014, 2(3), 403-416; doi:10.3390/toxics2030403
Received: 20 May 2014 / Revised: 29 July 2014 / Accepted: 30 July 2014 / Published: 11 August 2014
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Toxics 2014, 2(3), 364-376; doi:10.3390/toxics2030364
Received: 21 February 2014 / Revised: 30 May 2014 / Accepted: 18 June 2014 / Published: 25 June 2014
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Toxics 2014, 2(2), 327-345; doi:10.3390/toxics2020327
Received: 6 May 2014 / Revised: 4 June 2014 / Accepted: 5 June 2014 / Published: 18 June 2014
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by , , ,  and
Toxics 2014, 2(2), 258-275; doi:10.3390/toxics2020258
Received: 2 April 2014 / Revised: 26 May 2014 / Accepted: 29 May 2014 / Published: 5 June 2014
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Toxics 2014, 2(1), 50-78; doi:10.3390/toxics2010050
Received: 14 January 2014 / Revised: 10 February 2014 / Accepted: 20 February 2014 / Published: 17 March 2014
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Toxicity of glutathione-binding metals: a review of targets and mechanisms.
Author: Federico M. Rubino
Affiliation: LaTMA – Laboratory for Analytical Toxicology and Metabolomics, Department of Health Sciences, Università degli Studi di Milano @ Ospedale San Paolo, v.Antonio di Rudinì 8, Milano, Italia
Abstract: Mercury, cadmium, arsenic and lead are priority targets for toxicological studies due to the frequent human exposure and to the significant burden of disease following acute and chronic intoxication. Among their common characteristics is chemical affinity to proteins and non-protein thiols and their inability to generate cellular oxidative stress by the best-known Fenton mechanism. Their health effects are however diverse: kidney and liver damage, cancer at specific sites, irreversible neurological damages with metal-specific features. Mechanisms for the induction of oxidative stress by interaction with the cell thiolome will be presented, on the basis of literature evidence and of experimental findings.

Type of paper: Article
Metal Speciation in the Therapy of Metal Toxicity.
Douglas M. Templeton
Department of Laboratory Medicine and Pathobiology University of Toronto, 1 King's College Circle, Toronto, M5S 1A8, Canada; E-Mail:
Metals ions and metallic elements produce varying degrees of toxicity in organisms with which they come into contact. Metal speciation is critical to understanding these adverse effects, and the adjectives "heavy" and "toxic" are not particularly helpful in describing individual elements.  As a broad generalization, the metallic form of an element is inert, and the ionic salts are the species that show more significant bioavailability. Yet the salts and other chelates of a metal ion can show quite different toxicities, as shown by a range of carcinogenic potential for various nickel species. Another important distinction comes when a metallic element is organified, increasing its lipophilicity and hence its ability to penetrate the blood brain barrier, as is seen for example with organic mercury and tin species. The therapeutic use of chelating agents itself introduces new speciation to the target metal in vivo, and this can affect not only its desired detoxification, but also introduce a potential for further mechanisms of toxicity.  Examples of therapeutic iron chelator species are discussed in this context, as well as the more recent aspects of development of chelation for uranium exposure.

Last update: 3 December 2014

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