Identification of Toxic Effects of Emerging Chemicals throughout the Reproductive Process

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Reproductive and Developmental Toxicity".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 655

Special Issue Editors


E-Mail Website
Guest Editor
School of Public Health, Nanjing Medical University, Nanjing 211166, China
Interests: environmental health; reproductive toxicology; emerging contaminants; exposome; metabolome; microbiome; reproductive and developmental toxicity
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
Interests: environmental health; early life exposome; epidemiology; microbiome in health and disease; host–microbiome interactions
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Interests: environmental epidemiology; epigenetic epidemiology; climate change; air pollution and health; built environment and health; exposure assessment using machine leaning and spatial and GIS techniques; child and adolescent health; biostatistics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, accelerated industrialization and technological innovation have increased the production and consumption of emerging chemicals. These emerging chemicals are not commonly monitored in the environment but have the potential to enter the environment and are continually found in construction materials, drinking water, food, cosmetics, household products, etc. Human biomonitoring studies have shown that people are exposed to various emerging chemicals in daily life, including but not limited to manufactured nanomaterials, flame retardants, new pesticides, and water disinfection byproducts. Some emerging chemicals have been reported to have adverse effects on reproductive health. However, the toxic effects of many emerging chemicals and the biological mechanisms behind them remain unclear.

Therefore, this Special Issue focuses on the identification of the toxic effects of emerging chemicals throughout the whole reproductive process, including reproductive system development, gametogenesis, embryonic development, and fetal growth. Research areas may include but are not limited to the following: exposure assessment of emerging chemicals using human biomonitoring methods, association analysis between emerging chemicals exposure and adverse reproductive outcomes based on human epidemiologic studies, reproductive and developmental toxicity assessment of emerging chemicals using in vitro, ex vivo, or in vivo models.

In this Special Issue, high-quality original articles and reviews are welcomed. We look forward to receiving your contributions.

Prof. Dr. Yankai Xia
Dr. Hein Min Tun
Dr. Rongbin Xu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • emerging chemicals
  • reproductive toxicology
  • reproductive system disorders
  • exposure assessment
  • risk assessment
  • biological mechanism

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 9051 KiB  
Article
The Male Reproductive Toxicity Caused by 2-Naphthylamine Was Related to Testicular Immunity Disorders
by Pengyuan Dai, Mengqian Ding, Jingyan Yu, Yuan Gao, Miaomiao Wang, Jie Ling, Shijue Dong, Xiaoning Zhang, Xuhui Zeng and Xiaoli Sun
Toxics 2024, 12(5), 342; https://doi.org/10.3390/toxics12050342 - 7 May 2024
Viewed by 183
Abstract
2-naphthylamine (NAP) was classified as a group I carcinogen associated with bladder cancer. The daily exposure is mostly from cigarette and E-cigarette smoke. NAP can lead to testicular atrophy and interstitial tissue hyperplasia; however, the outcomes of NAP treatment on spermatogenesis and the [...] Read more.
2-naphthylamine (NAP) was classified as a group I carcinogen associated with bladder cancer. The daily exposure is mostly from cigarette and E-cigarette smoke. NAP can lead to testicular atrophy and interstitial tissue hyperplasia; however, the outcomes of NAP treatment on spermatogenesis and the associated mechanisms have not been reported. The study aimed to investigate the effect of NAP on spermatogenesis and sperm physiologic functions after being persistently exposed to NAP at 5, 20, and 40 mg/kg for 35 days. We found that sperm motility, progressive motility, sperm average path velocity, and straight-line velocity declined remarkably in the NAP (40 mg/kg) treated group, and the sperm deformation rate rose upon NAP administration. The testis immunity- and lipid metabolism-associated processes were enriched from RNA-sequence profiling. Plvap, Ccr7, Foxn1, Trim29, Sirpb1c, Cfd, and Lpar4 involved in testis immunity and Pnliprp1 that inhibit triglyceride and cholesterol absorption were confirmed to rise dramatically in the NAP-exposed group. The increased total cholesterol and CD68 levels were observed in the testis from the NAP-exposed group. Gpx5, serving as an antioxidant in sperm plasma, and Semg1, which contributes to sperm progressive motility, were both down-regulated. We concluded that the short-term exposure to NAP caused reproductive toxicity, primarily due to the inflammatory abnormality in the testis. Full article
Show Figures

Figure 1

Back to TopTop