Special Issue "Asymmetric Organocatalysis"
A special issue of Symmetry (ISSN 2073-8994).
Deadline for manuscript submissions: closed (31 March 2011)
Prof. Dr. Svetlana Tsogoeva
Institut für Organische Chemie I, Friedrich-Alexander Universität Erlangen-Nürnberg, Henkestrasse 42, 91054 Erlangen, Germany
Phone: +49 9131 85 22541
Fax: +49 9131 85 26865
Interests: asymmetric organocatalysis and organo-autocatalysis; synthesis of natural product hybrids for medicinal chemistry; redox-active metal complexes for asymmetric oxidation reactions
Evidently, enantiomers of bioactive compounds often have very different and, even opposite pharmacologic effects. Hitherto, many successful strategies were invented by chemists in order to obtain enantiomerically pure drugs and/or their intermediates.
Asymmetric organocatalysis, which is a powerful and environmentally friendly new methodology, facilitates strategies that provide an alternative to the conventional processes, which use transition-metal-complexes.
In many cases, the effectiveness of organocatalysts relies on covalent bonding: e.g. enamine/iminium ion activation by Lewis basic secondary or primary amines, or on the hydrogen bonding interactions: e.g. non-covalent catalysis with ureas and thioureas, diols, etc. Over the past years, a remarkable number of new enantioselective reactions subject to Brønsted- or Lewis-acid catalysis have been identified. Specifically, research has been focused on bi- and multi-functional catalysts containing Lewis or Brønsted basic moieties in combination with additional Lewis/Brønsted acidic functionality or hydrogen bond donors.Another fascinating organocatalytic system uses chiral phase-transfer catalysts (PTC).
Contributions are invited on all types of asymmetric organocatalysis and include:
- covalent and non-covalent organocatalysis,
- Lewis- or Brønsted-base organocatalysis,
- Brønsted- or Lewis-acid organocatalysis,
- asymmetric PTC,
- bi- and multi-functional organocatalysis.
Prof. Dr. Svetlana Tsogoeva
Review: Prolinethioamides versus Prolinamides in Organocatalyzed Aldol Reactions—A Comparative Study
Symmetry 2011, 3(2), 265-282; doi:10.3390/sym3020265
Received: 7 February 2011; in revised form: 23 May 2011 / Accepted: 24 May 2011 / Published: 1 June 2011| Download PDF Full-text (330 KB)
Symmetry 2011, 3(2), 220-245; doi:10.3390/sym3020220
Received: 29 March 2011; in revised form: 10 May 2011 / Accepted: 11 May 2011 / Published: 23 May 2011| Download PDF Full-text (1519 KB)
Article: Facile and Convenient One-Pot Process for the Synthesis of Spirooxindole Derivatives in High Optical Purity Using (−)-(S)-Brevicolline as an Organocatalyst
Symmetry 2011, 3(2), 165-170; doi:10.3390/sym3020165
Received: 10 March 2011; in revised form: 11 April 2011 / Accepted: 12 April 2011 / Published: 20 April 2011| Download PDF Full-text (179 KB)
Article: Primary Amino Acid Lithium Salt-Catalyzed Asymmetric Michael Addition of Carbon Nucleophiles to Enones
Symmetry 2011, 3(2), 155-164; doi:10.3390/sym3020155
Received: 18 February 2011; in revised form: 6 April 2011 / Accepted: 7 April 2011 / Published: 8 April 2011| Download PDF Full-text (134 KB)
Symmetry 2011, 3(1), 84-125; doi:10.3390/sym3010084
Received: 18 February 2011; in revised form: 8 March 2011 / Accepted: 9 March 2011 / Published: 22 March 2011| Download PDF Full-text (457 KB)
Last update: 5 March 2014