Symmetry 2011, 3(2), 265-282; doi:10.3390/sym3020265
Review

Prolinethioamides versus Prolinamides in Organocatalyzed Aldol Reactions—A Comparative Study

Dorota Gryko* email, Mikołaj Chromińskiemail and Dominika J. Pielacińskaemail
Institute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland
* Author to whom correspondence should be addressed.
Received: 7 February 2011; in revised form: 23 May 2011 / Accepted: 24 May 2011 / Published: 1 June 2011
(This article belongs to the Special Issue Asymmetric Organocatalysis)
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Abstract: Various organocatalysts have been developed for the aldol reaction but particular attention has been paid to prolinamide derivatives. They are easy to prepare and their catalytic activity can be readily tuned through structural modification. In this review, the comparison of catalytic activities between prolinethioamides and their respective amides in direct asymmetric aldol reactions is presented.
Keywords: organocatalysis; prolinethioamides; prolinamides; aldol reaction; enamine-iminium catalysis

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MDPI and ACS Style

Gryko, D.; Chromiński, M.; Pielacińska, D.J. Prolinethioamides versus Prolinamides in Organocatalyzed Aldol Reactions—A Comparative Study. Symmetry 2011, 3, 265-282.

AMA Style

Gryko D, Chromiński M, Pielacińska DJ. Prolinethioamides versus Prolinamides in Organocatalyzed Aldol Reactions—A Comparative Study. Symmetry. 2011; 3(2):265-282.

Chicago/Turabian Style

Gryko, Dorota; Chromiński, Mikołaj; Pielacińska, Dominika J. 2011. "Prolinethioamides versus Prolinamides in Organocatalyzed Aldol Reactions—A Comparative Study." Symmetry 3, no. 2: 265-282.

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