Special Issue "Supercritical Fluid Extraction"

A special issue of Separations (ISSN 2297-8739).

Deadline for manuscript submissions: 31 January 2018

Special Issue Editor

Guest Editor
Dr. Beatriz P. Nobre

Centro de Química Estrutural, Instituto Superior Técnico, Lisbon University, Lisbon, Portugal
Website | E-Mail
Interests: Supercritical fluids (SCFs); Extraction, fractionation, purification and microencapsulation processes with SCFs and pressurized liquids, supercritical micronization of pharmaceuticals compounds. Use of SCFs for the valorization of biomass (from plants, microorganisms, industrial wastes/by-products) within biorefinery concept. Biological activity of natural compounds (anti-cancer).

Special Issue Information

Dear Colleagues

This Special Issue is dedicated to supercritical fluid extraction (SFE) research. Supercritical fluids (SCFs) are a class of sustainable green solvents with a broad range of applications. From chemicals to food, nutraceutics, pharmaceutics or bioenergy SCFs have been widely used. The readily tunable solvent properties of SCFs together with the high-diffusivity, low viscosity and low surface tension makes them highly suitable and excellent solvents for extraction, fractionation and purification processes, allowing achieving high yield, high efficiency and good selectivity.

Extraction of added-value compounds from natural sources is a prominent subject on today’s agenda. Market and consumers demand, together with international policies/regulations, increased industrial interest in natural bioactive compounds. SFE of these added-value compounds from natural sources, such as plants, microorganisms (e.g. microalgae, yeasts, fungi and bacteria) or agro-industrial/food/crop wastes is therefore hot topic and a major subject for R&D.

This Special Issue aims to disseminate the latest research regarding SFE. Authors are invited to present contributions related, but not limited, to SFE, fractionation and purification processes. Moreover, papers concerning a combination of SFE and other industrial processes are also encouraged. I hope that the topics included will reflect the high potential of SFE as an alternative green process.

Dr. Beatriz P. Nobre
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Supercritical Fluid extraction
  • Supercritical CO2
  • Fractionation
  • Purification
  • Separation
  • Supercritical Fluid Cromatography
  • Natural Products
  • Antioxidants
  • Bioactive compounds
  • Valorisation
  • Sustainability

Published Papers (1 paper)

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Open AccessReview Extraction by Subcritical and Supercritical Water, Methanol, Ethanol and Their Mixtures
Separations 2018, 5(1), 4; doi:10.3390/separations5010004
Received: 5 November 2017 / Revised: 22 December 2017 / Accepted: 27 December 2017 / Published: 1 January 2018
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Hot, subcritical and supercritical water, methanol, ethanol and their binary mixtures have been employed to treat fuels (desulfurize coal and recover liquid fuels from coal and oil shales) and to extract valuable solutes from biomass. The properties of these solvents that are relevant
[...] Read more.
Hot, subcritical and supercritical water, methanol, ethanol and their binary mixtures have been employed to treat fuels (desulfurize coal and recover liquid fuels from coal and oil shales) and to extract valuable solutes from biomass. The properties of these solvents that are relevant to their extraction abilities are presented. Various extraction methods: accelerated solvent extraction (ASE), pressurized liquid extraction (PLE), supercritical fluid extraction (SFE, but excluding supercritical carbon dioxide) with these solvents, including microwave- and ultrasound-assisted extraction, are dealt with. The extraction systems are extensively illustrated and discussed. Full article
(This article belongs to the Special Issue Supercritical Fluid Extraction)

Figure 1

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Extraction by supercritical and subcritical water, methanol, and ethanol and their mixtures
Author: Yizhak Marcus
Affiliation: Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Abstract: The properties of hot and critical water, methanol, ethanol and their binary mixtures that are relevant to their solvent extraction abilities are presented. These solvents have been employed to extract bioactive substances from a host of natural sources, but also of other valuable solutes or, on the other hand, for the removal of undesirable solutes from the main stream of production lines, and such systems are fully illustrated and discussed. Various extraction methods with these solvents, including solid-liquid micro-extraction, microwave-assisted extraction, and ultrasound-assisted extraction.

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