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Biosensors for Cancer Detection and Monitoring
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Biosensors for Cancer Detection and Monitoring

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (20 November 2020) | Viewed by 6068

Special Issue Editor

Prof. Dr. Noemí de-los-Santos-Álvarez

E-Mail Website
Guest Editor
Departament of Physical and Analytical Chemistry, University of Oviedo, Julián Clavería 8, 33006 Oviedo, Spain
Interests: biosensors and bioassays; electroanalytical methods of detection in food; environmental and clinical analysis; aptamer selection; aptasensors; genosensors; DNA amplification schemes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The risk of being diagnosed with cancer is increasing worldwide in spite of the huge research effort and economic investment in understanding the molecular foundations of this group of diseases. Fortunately, early detection as well as adequate stratification and treatment monitoring can improve the survival rate in many types of cancer. This undoubtedly fuels the need for economic, simple, and low-invasive analytical methods to implement affordable screening plans in health services. Today, the range of potential biomarkers is larger than ever and no longer limited to a few proteins and their overall concentration. The detection of isoforms or specific post-translational modifications of a certain molecule is now regarded as more informative, implying a significant challenge for current methods in terms of sensitivity and selectivity. Their validation to reach the clinic either individually or in panels strongly relies on rapid and easy-to-handle analytical methodology. Biosensors and bioassays are the ideal tools to cover these niches by using a variety of natural or synthetic probes (antibodies, nucleic acids, aptamers, molecular imprinting polymers, etc.) in combination with smart (nano)materials or amplification schemes to construct devices to be implemented in decentralized or low-resource settings.

I cordially invite you to contribute to this Special Issue, which is intended to collect the recent advances in the development and design of novel receptors or sensing platforms for cancer biomarkers of any kind (nucleic acids, proteins, free tumor cells, etc.), improvements in common pitfalls such as fouling or unspecific signals or limited selectivity, and the clinical validation of biosensors and bioassays.

Dr. Noemí de-los-Santos-Álvarez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cancer biomarker detection
  • Cancer monitoring
  • Nucleic acid-based sensors
  • Aptasensors
  • Immunosensors
  • MIP-based sensors
  • Cytosensors
  • Microfluidics
  • Nanomaterial-based sensors
  • Nucleic-acid amplification schemes
  • Liquid biopsy.

Published Papers (2 papers)

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Research

13 pages, 2051 KiB  
Article
Anti-p53 Autoantibody Detection in Automatic Glass Capillary Immunoassay Platform for Screening of Oral Cavity Squamous Cell Carcinoma
by Yen-Heng Lin, Chih-Ching Wu, Wan-Ling Chen and Kai-Ping Chang
Sensors 2020, 20(4), 971; https://doi.org/10.3390/s20040971 - 11 Feb 2020
Cited by 11 | Viewed by 2481
Abstract
The incidence of oral squamous cell carcinoma (OSCC), which is one of the most common cancers worldwide, has been increasing. Serum anti-p53 autoantibody is one of the most sensitive biomarkers for OSCC. Currently, the most commonly used method on clinical screening platforms is [...] Read more.
The incidence of oral squamous cell carcinoma (OSCC), which is one of the most common cancers worldwide, has been increasing. Serum anti-p53 autoantibody is one of the most sensitive biomarkers for OSCC. Currently, the most commonly used method on clinical screening platforms is the enzyme-linked immunosorbent assay, owing to its high specificity and repeatability. However, conducting immunoassays on 96-well plates is typically time consuming, thereby limiting its clinical applications for fast diagnosis and immediate prognosis of rapidly progressive diseases. The present study performed immunoassays in glass capillaries of 1-mm internal diameter, which increases the surface to volume ratio of the reaction, to shorten the time needed for immunoassay. The immunoassay was automated while using linear motorized stages and a syringe pump. The results indicated that, when compared with the 96-well plate immunoassay, the glass capillary immunoassay decreased the reaction time from typical 120 min to 45 min, reduced the amount of reagent from typical 50 µL to 15 µL, and required only simple equipment setup. Moreover, the limit of detection for glass capillary anti-p53 autoantibody immunoassay was 0.46 ng mL−1, which is close to the 0.19 ng mL−1 value of the conventional 96-well plate assay, and the glass capillary method had a broader detection range. The apparatus was used to detect the serum anti-p53 autoantibody concentration in clinical patients and compare its results with the conventional 96-well plate method results, which suggested that both of the methods detect the same trend in the relative concentration of serum anti-p53 autoantibody in healthy individuals or patients with OSCC. Full article
(This article belongs to the Special Issue Biosensors for Cancer Detection and Monitoring)
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14 pages, 5298 KiB  
Article
A Non-Enzymatic Sensor Based on Trimetallic Nanoalloy with Poly (Diallyldimethylammonium Chloride)-Capped Reduced Graphene Oxide for Dynamic Monitoring Hydrogen Peroxide Production by Cancerous Cells
by Jun Jiao, Meixin Pan, Xinran Liu, Binshuai Li, Jian Liu and Qiang Chen
Sensors 2020, 20(1), 71; https://doi.org/10.3390/s20010071 - 21 Dec 2019
Cited by 11 | Viewed by 3063
Abstract
Catching cancer at an early stage is necessary to make it easier to treat and to save people’s lives rather than just extending them. Reactive oxygen species (ROS) have sparked a huge interest owing to their vital role in various biological processes, especially [...] Read more.
Catching cancer at an early stage is necessary to make it easier to treat and to save people’s lives rather than just extending them. Reactive oxygen species (ROS) have sparked a huge interest owing to their vital role in various biological processes, especially in tumorigenesis, thus leading to the potential of ROS as prognostic biomarkers for cancer. Herein, a non-enzymatic biosensor for the dynamic monitoring of intracellular hydrogen peroxide (H2O2), the most important ROS, via an effective electrode composed of poly (diallyldimethylammonium chloride) (PDDA)-capped reduced graphene oxide (RGO) nanosheets with high loading trimetallic AuPtAg nanoalloy, is proposed. The designed biosensor was able to measure H2O2 released from different cancerous cells promptly and precisely owing to the impressive conductivity of RGO and PDDA and the excellent synergistic effect of the ternary alloy in boosting the electrocatalytic activity. Built upon the peroxidase-like activity of the nanoalloy, the developed sensor exhibited distinguished electrochemical performance, resulting in a low detection limit of 1.2 nM and a wide linear range from 0.05 μM to 5.5 mM. Our approach offers a significant contribution toward the further elucidation of the role of ROS in carcinogenesis and the effective screening of cancer at an early stage. Full article
(This article belongs to the Special Issue Biosensors for Cancer Detection and Monitoring)
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