In Vitro-In Vivo Correlation (IVIVC) and Mechanistic Pharmacokinetic Models: Bridging Drug In Vitro Characteristics and the In Vivo Behaviors

Dear Colleagues,

Pharmacokinetic modeling can assist in the understanding of drug behavior in the body and thus plays an essential role in new drug development. Establishing in vitro–in vivo correlation (IVIVC) bridges the gap between in vitro characteristics and in vivo drug behaviors, which can provide valuable insights for formulation development and predicting clinical outcomes. Therefore, the reliable link provided by the robust model between in vitro data and in vivo performance has the potential to reduce the costs and enhance the efficiency of preclinical and clinical studies. In recent years, significant progress has been made in various modeling techniques, particularly in the areas of IVIVC and mechanistic pharmacokinetic modeling.

This Special Issue aims to explore the most recent advancements and practical applications related to IVIVC and mechanistic pharmacokinetic modeling, including, but not limited to, the following:

1. Development and validation of IVIVC models;
2. Integration of in vitro data with in vivo pharmacokinetic profiles;
3. Advancements in mechanistic pharmacokinetic modeling techniques;
4. Applications of pharmacokinetic modeling in drug–drug interactions;
5. Utilization of IVIVC and mechanistic pharmacokinetic modeling in regulatory submissions;
6. Case studies demonstrating the translational potential of IVIVC and mechanistic pharmacokinetic modeling in pharmacy practice.

In this Special Issue, original research articles and reviews are welcome.

I look forward to receiving your contributions.

Dr. Zhijun Kevin Wang
Guest Editor

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• IVIVC
• PBPK
• pharmacokinetic modeling
• mechanistic modeling
• drug development
• drug–drug interactions
• sensitivity analysis
• pharmacometrics