Bioadhesive Nanocarriers: Innovations in Drug Release and Therapeutic Effectiveness

Dear Colleagues,

Bioadhesive nanocarriers are a notable field for drug delivery, standing out for their ability to combine the advantages of nanotechnology with bioadhesive potential. This substantial property can be understood using biocompatible and biodegradable materials which are capable of interacting safely and effectively with mucous membranes and skin. A prolonged stay at the application site, ensured by the bioadhesive potential, is essential to maximize the therapeutic efficacy of topical treatments. When combined with the controlled release profile, bioadhesion not only ensures that they remain at the administration site for prolonged periods, but also facilitates intimate contact, which can favor the permeation of the drug in a controlled manner across different biological barriers. The result is a long-lasting therapeutic effect, maximizing the effectiveness of the treatment, minimizing the need for frequent administrations, and, consequently, improving patient the adherence to the proposed treatment. In this context, bioadhesive nanocarriers have been used in the most varied pharmaceutical and cosmetic formulations, such as ophthalmic products, nasal sprays, gels, and polymeric films for different routes, such as cutaneous, vaginal, buccal, or sublingual.

This Special Issue aims to thoroughly examine the bioadhesive effect of nanocarriers, an essential aspect of enhancing drug delivery. It also aims to investigate how bioadhesion enhances therapeutic effectiveness via facilitating drug release and integration into various pharmaceutical forms for diverse routes of administration. Researchers are invited to submit studies covering the development, characterization, therapeutic efficacy, and safety of bioadhesive nanocarriers.

Prof. Dr. Luana Mota Ferreira
Dr. Marcel Henrique Marcondes Sari
Dr. Reolon Jéssica Brandão
Guest Editors

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• nanocarriers
• bioadhesive materials
• mucoadhesive materials
• drug delivery
• topic formulations
• efficacy optimization