Recent Progress & Critical Challenges in Non-Viral Nucleic Acid Therapy

Dear Colleagues,

Many DNA and RNA sequences have been shown to add, correct, or suppress genes in mammalian cells. These abilities have tremendous potential treating many life-threatening diseases. However, transforming DNA/RNA molecules into safe, stable, and effective therapies with well-defined dosing regimens is still an unaccomplished goal. *Pharmaceuticals* will publish a special issue, entitled "Recent Progress & Critical Challenges in Non-Viral Nucleic Acid Therapy", which aims to provide a comprehensive overview of recent progress in the development of non-viral nucleic acid therapies and the challenges hampering their translation into the clinic. I cordially invite contributions of review articles and original research

papers that discuss any of the following topics:

I)     The development of novel DNA/RNA vectors;

II)    Active and passive targeting strategies of non-viral carriers,

III)  Cell-specific binding, internalization, and sub-cellular trafficking,

IV)   PK/PD considerations for non-viral particles, and

V)     Progress and hurdles in the manufacture of non-viral DNA/RNA therapies.

Dr. Mohamed E.H. ElSayed
Guest Editor

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