Special Issue "Neuroactive Compounds"

Guest Editor
Dr. Maurice Tangui
INSERM U. 710, University of Montpellier 2, 34095 Montpellier cedex 5, France
Website: http://www.mmdn.univ-montp2.fr/equipe2.html
E-Mail: tangui.maurice@univ-montp2.fr

Dear Colleagues,

Research in Neuroscience has never been so active, taking benefits from recent developments in functional imaging, molecular biology and transgenesis, or improvements in animals’ cognitive behavioral analyses. Paradoxically, validation of new therapeutic strategies and marketing of really innovative medicine against pathologies with major social issues like Alzheimer’s disease and related neurodegenerative disorders, ischemic insults, depression, or schizophrenia mark time and do not find way out in a near future. Drug development pipelines of pharmaceutical companies remain alarmingly empty.
This combined Special Issue of Molecules and Pharmaceuticals, on Neuroactive Compounds, will offer an unique forum to present the chemistry, pharmacology and therapeutic opportunities offered by new and innovative molecular series in all areas of neuropharmacology and neuroscience. I strongly encourage authors to submit papers for this special issue, within the scope of Molecules and Pharmaceuticals, and I hope that the fields covered will allow to rise our hopes in seeing soon the validation of breakthrough treatments in central pathologies of major concern.

Dr. Tangui Maurice
Guest Editor

Related Special Issues

Neuroactive Compounds in Molecules

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• psychoactive drugs
• neuroprotective agents
• antidepressant
• anxiolytics
• anti-stress drugs
• brain imaging tools
• brain penetration
• blood-brain barrier agents

Type of Paper: Review
Title: NBM-T-L-BMX-OS01, a Novel Histone Deacetylase Inhibitor (HDACi) has a Potent Neuroprotective Effects in MPTP-Induced Parkinson’s Disease Model
Authors: Ying-C  Yang¹, Wei-Jan Huang²_, Yu-Chen Huang³, Chung-Yang Huang³, Chia-Nan Chen³
Affiliation: ¹Department of Animal Science, National I-Lan University, I-Lan, Taiwan
²Graduate Institute of Pharmacognosy, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
³NatureWise Biotech and Medicals Corporation, Taipei 115, Taiwan; E-Mail: cnchen@mail.nbic.org.tw
Abstract: Epigenetic changes are key factors controlling several gene expressions and are known to be correlated with many neural processes, neurodegenerative diseases and cancer. There is increasing evidence demonstrated that histone deacetylase inhibitor (HDACi) can possess neuroprotective effects via several of mechanisms. Previously, we investigated a novel HDAC8-specific inhibitor was identified from our laboratory, termed NBM-T-L-BMX-OS01 (BMX). This agent was derived from the semi-synthesis of osthole, isolated from Cnidium monnieri (L.) Cuss., and was shown to be a potent suppressor for tumor growth in xenograft model and markedly improving the learn and memory in Morris Water Maze task. In this present study, we found that pre-treatment with BMX can efficiently prevention of MPTP (1-methyl-4-phenyl-1, 2. 3, 6-tetrahydropyridine)-induced a parkinsonian syndrome.  Furthermore, we were interesting whether BMX can be used for the therapy of Parkinson’s disease. Mice were injected intraperitoneally (ip) with MPTP (30 mg/kg) or without MPTP (control group) once daily for 7 days to induce a sub-acute state then randomized into three groups. Three groups of MPTP-induced parkinson’s disease mice were treated with compounds or without (negative control group). Compounds, BMX (BMX group) and SAHA (suberoylanilide hydroxamic acid, a noted pan-HDAC inhibitor) (SAHA group) were injected ip with the same dose (5 mg/kg) into mice once daily for 7 days then determined the neuroprotective effects by using the rotary. Our data demonstrated that BMX group and SAHA group mice compared with negative control group mice were exert a significantly neuroprotective effects in MPTP-induced Parkinson’s disease model. Taken together, our data suggested that administration of BMX (HDAC8-specific inhibitor) or SAHA (pan-HDACi) may be as an efficiently strategy to prevent or cure in MPTP-induced Parkinson’s disease models. These findings provide further evidence to suggest that inhibition of HDAC8 activity may be as an important approach for therapy of Parkinson’s disease.
Keywords: NBM-T-L-BMX-OS01; Parkinson’s disease; MPTP; Histone deactylase 8 inhibitor; HDACs