Special Issue "Genes, Mechanisms and Drugs for Asthma"
A special issue of Pharmaceuticals (ISSN 1424-8247).
Deadline for manuscript submissions: closed (31 March 2011)
Dr. P. Hemachandra Reddy
Neurogenetics Laboratory, Neuroscience Division, Oregon National Primate Research Center, West Campus, Oregon Health and Science University, 505 N.W., 185th Avenue Beaverton, OR 97006, USA
Phone: +1 503 418 2625 (office); +1 503 418 2627 (lab)
Fax: +1 503 418 2501
Interests: aging; neurodegenerative diseases; gene expression analysis; transgenic mouse models; mitochondrial biology; mitochondrial function/dysfunction; mitochondrial therapeutics; mitochondrial dynamics
Asthma is a complex, inflammatory disorder characterized by airflow obstruction of variable degrees, bronchial hyper-responsiveness, and airway inflammation. Asthma is caused by environmental factors and a combination of genetic and environmental stimuli. Intense genetic studies in the last decade revealed that multiple genetic loci are involved in the etiology of asthma. Recent cellular, molecular, and animal model studies have revealed that several cellular events are involved in the progression of asthma, including: increased T-helper type 2 cytokines leading to the recruitment of inflammatory cells to the airway and, increased production of reactive oxygen species and mitochondrial dysfunction in the activated inflammatory cells, leading to tissue injury in the bronchial epithelium. The purpose of this issue is to assess the current status of research in asthma: 1) recent progress in genetic studies of asthma; 2) advances in cells/tissues from asthmatic humans, and induced animal models of allergic asthma; and 3) recent developments in therapeutics of asthma. This issue also discusses the current status of mitochondrial approaches in induced animal models of allergic asthma, and also in patients with asthma.
Dr. P. Hemachandra Reddy
- reactive oxygen species
- mitochondrial dysfunction
- oxidative stress
- antioxidant therapeutics
- allergic asthma
- airway inflammation
Pharmaceuticals 2011, 4(1), 187-201; doi:10.3390/ph4010187
Received: 4 November 2010; in revised form: 3 January 2011 / Accepted: 10 January 2011 / Published: 12 January 2011| Download PDF Full-text (242 KB) | Download XML Full-text
Review: Mitochondrial Dysfunction and Oxidative Stress in Asthma: Implications for Mitochondria-Targeted Antioxidant Therapeutics
Pharmaceuticals 2011, 4(3), 429-456; doi:10.3390/ph4030429
Received: 9 February 2011; in revised form: 18 February 2011 / Accepted: 21 February 2011 / Published: 25 February 2011| Download PDF Full-text (644 KB) | Download XML Full-text
Last update: 4 March 2014