Special Issue "Antiasthmatic Drugs"
A special issue of Pharmaceuticals (ISSN 1424-8247).
Deadline for manuscript submissions: closed (31 December 2009)
Prof. Dr. Paolo Montuschi
Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy
Phone: +39 06 30156092
Fax: +39 06 30156292
Interests: asthma; chronic obstructive pulmonary disease (COPD); pharmacological therapy of asthma and COPD; allergy; non-invasive monitoring of lung inflammation; exhaled breath condensate; exhaled nitric oxide; electronic nose; metabolomics
Prof. Dr. Peter J. Barnes
National Heart and Lung Institute, Imperial College, London, UK
Phone: +44 207 351 8174
Fax: +44 207 351 5675
Interests: molecular mechanisms and therapy of asthma and COPD
All papers should be submitted to email@example.com. To be published continuously until the deadline and papers will be listed together at the special issue website.
Submitted papers should not have been published nor be under consideration for publication elsewhere. All papers are refereed through a peer-review process. A guide for authors is available on the Instructions for Authors page. Pharmaceuticals is a new international, peer-reviewed, quarterly open access journal published by MDPI.
Article Processing Charges (APC) for publication in this open access journal are waived for well-prepared manuscripts submitted by 30 June 2010. English correction or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those paper accepted for publication, that require extensive additional formatting and/or English corrections.
Review: Inhaled Corticosteroids
Pharmaceuticals 2010, 3(3), 514-540; doi:10.3390/ph3030514
Received: 29 January 2010 / Accepted: 2 March 2010 / Published: 8 March 2010| Download PDF Full-text (1438 KB) | Download XML Full-text
Pharmaceuticals 2010, 3(3), 725-747; doi:10.3390/ph3030725
Received: 14 January 2010 / Accepted: 18 March 2010 / Published: 18 March 2010| Download PDF Full-text (363 KB) | Download XML Full-text
Review: Beta-Adrenergic Agonists
Pharmaceuticals 2010, 3(4), 1016-1044; doi:10.3390/ph3041016
Received: 2 February 2010; in revised form: 15 March 2010 / Accepted: 26 March 2010 / Published: 30 March 2010| Download PDF Full-text (1162 KB)
Pharmaceuticals 2010, 3(6), 1792-1811; doi:10.3390/ph3061792
Received: 21 April 2010; in revised form: 13 May 2010 / Accepted: 31 May 2010 / Published: 2 June 2010| Download PDF Full-text (368 KB)
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Manuscript ID: Pharmaceuticals-Antiasthmaticd-20090518- Barnes-uk
Type of Paper: Review
Title: Antiasthmatic Drugs
Authors: Paolo Montuschi 1 and Peter J. Barnes 2
Affiliations: 1Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy,
2Airway Disease Section, Imperial College, School of Medicine, National Heart and Lung Institute, London, United Kingdom
Abstract: Pharmacologic treatment is the mainstay of management in most patients with asthma. The primary goals of treatment of asthma are relief of symptoms, normalization of pulmonary function, prevention of acute exacerbations, reduction of airway hyper-reactivity, and improvement of quality of life. A relevant goal in asthma control is to prevent the putative long-term consequences of airway inflammation, particularly airway remodelling. However, whether pharmacological control of airway inflammation positively influences the natural history of asthma is currently unknown partially due to the relative short duration of clinical trials. Different long-term control medications including inhaled corticosteroids, leukotriene receptor antagonists, long-acting beta-agonists, cromones, and theophylline, are regularly used for asthma control. Short-acting beta-adrenergic agonists, that can be combined with antimuscarinic drugs, are generally effective for treating acute asthma exacerbations. Pharmacotherapy of asthma is characterized by a stepwise approach based on increasing medications until asthma is controlled, and decreasing medications when possible to minimize side effects. In general, the intensity of treatment should match the severity of symptoms. As a result, patients with infrequent and mild symptoms should be treated intermittently whereas patients with persistent symptoms should receive long-term controller medications. However, the threshold for initiating inhaled corticosteroid therapy is not evidence-based and the concept that airway remodelling is evitable in patients who take these drugs regularly is not fully elucidated. Some reports have raised the question about the need for chronic controller therapy in mild persistent asthma. Regular use of inhaled corticosteroids, generally the most effective long-term controller drugs for asthma, is associated with improvements in symptoms and lung function, and with reductions in exacerbations, hospitalizations and deaths from asthma. In patients with asthma who are not adequately controlled with inhaled corticosteroids alone, add-on therapy with long-acting beta agonists or leukotriene receptor antagonists is generally preferred to increasing the dose of inhaled corticosteroids. Combination of inhaled corticosteroids and long-acting beta-adrenergic agonists is generally effective for asthma control. However, issues regarding safety of long-acting beta agonists, even in combination with inhaled corticosteroids, have been raised. A minority of patients with asthma has a severe disease that is poorly responsive to antiasthmatic drugs that are currently available. In these patients, search for new drugs for asthma is justified. The pharmacologic response to antiasthmatic drugs such as leukotriene receptor antagonists, and to a much lesser extent inhaled corticosteroids, is characterized by inter-individual variability. This might be partially explained by the heterogeneity of asthma and the different selectivity in the mechanisms of action of drugs for asthma. Identification of phenotypes of patients with asthma who are more likely to respond to different classes of antiasthmatic drugs is relevant for choosing the best therapeutic strategy in the individual patients with asthma. This special issue will present the pharmacological profile, including mechanisms of action, of the principal classes of antiasthmatic drugs, review data on their efficacy and safety, discuss controversial issues including safety of long acting beta agonists, and present the possible pharmacological strategies for asthma control.
Keywords: asthma; antiasthmatic drugs; asthma control; airway inflammation; inhaled corticosteroids; leukotriene receptor antagonists; short-acting beta agonists; long-acting beta agonists; chromones; theophylline
Last update: 25 September 2009