Nutrients

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Dear Colleagues,

Celiac disease (CD) is an autoimmune-related disease causing inflammation in the small bowel triggered by the ingestion of gluten. The only effective and safe treatment for celiac disease (CD) and gluten-related disorders is a lifelong, strict exclusion of gluten—the so-called gluten-free diet (GFD). Both inadequate dietary intake and/or diminished uptake due to intestinal damage contribute to nutrient deficiencies, most of which can be restored with a GFD and/or supplementation. On the other hand, numerous studies have reported nutritional imbalances associated with the GFD. Therapeutic protocols should include nutritional education to teach subjects affected by untreated and treated CD and gluten related disorders about the importance of reading labels, choosing foods, and combining macro- and micronutrients. New insights into the nutritional aspects of CD and gluten-related disorders present an exciting scientific challenge for researchers.

Dr. Usai-Satta Paolo
Guest Editor

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Keywords

celiac disease
gluten-related disorder
gluten-free diet
nutritional deficiency
nutritional protocols

Published Papers (1 paper)

Review

11 pages, 2910 KiB

Open AccessReview

Familial Mediterranean Fever and Diet: A Narrative Review of the Scientific Literature

by Pasquale Mansueto, Aurelio Seidita, Marta Chiavetta, Dario Genovese, Alessandra Giuliano, Walter Priano, Antonio Carroccio, Alessandra Casuccio and Emanuele Amodio

Nutrients 2022, 14(15), 3216; https://doi.org/10.3390/nu14153216 - 5 Aug 2022

Cited by 3 | Viewed by 5963

Abstract

Background: Familial Mediterranean fever (FMF) is an inherited autoinflammatory disease characterized by short acute attacks, with an as yet unknown cause. Several authors have investigated the role of some foods as potential triggers. This narrative review aims to analyze the correlation between diet and FMF clinical outcomes. Methods: The review was carried out following PRISMA statement guidelines, including all cross-sectional, case-crossover, and trial studies written in English and conducted between 1974 and 2022. Results: Overall, 642 records were identified through PubMed/MEDLINE (292) and Scopus (350), and seven studies were included: three out of seven (43%) studies evaluated FMF attack recurrence or time between consumption of high-fat foods and FMF attacks, while another three (43%) articles variously assessed FMF severity, and one (14%) evaluated the distribution of MEFV mutations. Conclusions: To date, conflicting results have been reported about fatty and salty food intake and FMF attack recurrence. Moreover, some authors have suggested a possible role of wheat. Finally, a diet rich in antioxidants and supplements with an anti-inflammatory effect could partially reduce symptoms and improve the well-being of FMF patients. Nevertheless, no conclusive data could be drawn about the impact of diet in FMF symptom triggering, and further studies are required to clarify this putative association. Full article

(This article belongs to the Special Issue Nutritional and Dietary Aspects in Celiac Sprue and Gluten-Related Disorders)

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