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Nutrients
Special Issues
Anti-inflammatory and Anti-obesity Properties of Food Bioactive Components
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Anti-inflammatory and Anti-obesity Properties of Food Bioactive Components

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 25 September 2024 | Viewed by 4232

Special Issue Editors

Dr. Monika Tomczykowa

E-Mail Website
Guest Editor
Department of Organic Chemistry, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Białystok, ul. Mickiewicza 2a, 15-222 Białystok, Poland
Interests: polyphenols; essential oils; plant raw materials as a source of compounds with high pro-health potential; synthesis of modified biologically active polyphenols; transdermal delivery systems for active ingredients
Dr. Michał Tomczyk

E-Mail Website
Guest Editor
Department of Pharmacognosy, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Białystok, ul. Mickiewicza 2a, 15-230 Białystok, Poland
Interests: pharmacognosy; phytochemistry; phytotherapy; natural compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Obesity is closely related to the occurrence of chronic low-grade inflammation. Even though its intensity is not high, the fact that the inflammation persists all the time is extremely unfavorable and destructive for the human body. Reducing one’s body weight, i.e., reducing obesity, and thus, chronic inflammation, can be greatly achieved thanks to a proper diet rich in compounds with anti-inflammatory and anti-obesity properties.

Food bioactive components are the basic nutrients or non-nutritive compounds that naturally occur in raw materials subjected to a technological process which strengthen, weaken or modify the physiological and metabolic functions of the body.

In this Special Issue, we aim to gather the latest scientific data both in the form of original research manuscripts and reviews relating to the anti-inflammatory and anti-obesity properties of compounds known as Food Bioactive Components (FBC) and the relationships between the presence and level of FBC content in food, their daily consumption and effectiveness in the fight against obesity and chronic inflammation.

Dr. Monika Tomczykowa
Dr. Michał Tomczyk
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food bioactive components (FBC)
  • chronic low-grade inflammation
  • obesity
  • molecular basis of biological activity of FBC

Published Papers (3 papers)

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Research

15 pages, 7149 KiB  
Article
Ginseng Berry Juice (GBJ) Regulates the Inflammation in Acute Ulcerative Mouse Models and the Major Bioactive Substances Are Ginsenosides Rb3, Rc, Rd, and Re
by Soon-Young Lee, Seung-Yub Song, Sung-Ho Lee, Gye-Yeop Kim, Jin-Woo Park, Chun-Sik Bae, Dae-Hun Park and Seung-Sik Cho
Nutrients 2024, 16(7), 1031; https://doi.org/10.3390/nu16071031 - 1 Apr 2024
Viewed by 740
Abstract
Panax ginseng fruit is known to have various biological effects owing to its large amount of saponins such as ginsenosides. In the present study, ginseng berry juice was confirmed to be effective against acute inflammation. Ginseng berry juice was used for analysis of [...] Read more.
Panax ginseng fruit is known to have various biological effects owing to its large amount of saponins such as ginsenosides. In the present study, ginseng berry juice was confirmed to be effective against acute inflammation. Ginseng berry juice was used for analysis of active constituents, antioxidant efficacy, and in vivo inflammation. A high-performance liquid chromatography method was used for analysis of ginsenosides. In an HCl/ethanol-induced acute gastric injury model, microscopic, immunofluorescent, and immunohistochemical techniques were used for analysis of inhibition of gastric injury and mechanism study. In a mouse model of acute gastritis induced with HCl/ethanol, ginseng berry juice (GBJ, 250 mg/kg) showed similar gastric injury inhibitory effects as cabbage water extract (CB, 500 mg/kg, P.O). GBJ dose-dependently modulated the pro-inflammatory cytokines such as Tumor Necrosis Factor-α (TNF-α), Interleukin-6 (IL-6), and Interleukin-13 (IL-13). GBJ inhibited the activation of Nuclear Factor kappa bB (NF-κB) and suppressed the expressions of cyclooxigenase-2 (COX-2) and prostaglandin 2 (PGE2). The anti-inflammatory effect of GBJ is attributed to ginsenosides which have anti-inflammatory effects. Productivity as an effective food source for acute gastritis was analyzed and showed that GBJ was superior to CB. In addition, as a functional food for suppressing acute ulcerative symptoms, it was thought that the efficacy of gastric protection products would be higher if GBJ were produced in the form of juice rather than through various extraction methods. Full article
(This article belongs to the Special Issue Anti-inflammatory and Anti-obesity Properties of Food Bioactive Components)
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15 pages, 2144 KiB  
Article
Chia Phenolic Extract Appear to Improve Small Intestinal Functionality, Morphology, Bacterial Populations, and Inflammation Biomarkers In Vivo (Gallus gallus)
by Marcella Duarte Villas Mishima, Hércia Stampini Duarte Martino, Nikolai Kolba, Nikita Agarwal, Cydney Jackson, Bárbara Pereira da Silva, Mariana Grancieri, Andressa de Assis, Vinícius Parzanini Brilhante de São José and Elad Tako
Nutrients 2023, 15(16), 3643; https://doi.org/10.3390/nu15163643 - 19 Aug 2023
Viewed by 1507
Abstract
Phenolic compounds can act as a substrate for colonic resident microbiota. Once the metabolites are absorbed and distributed throughout the body, they can have diverse effects on the gut. The objective of this study was to evaluate the effects of the intra-amniotic administration [...] Read more.
Phenolic compounds can act as a substrate for colonic resident microbiota. Once the metabolites are absorbed and distributed throughout the body, they can have diverse effects on the gut. The objective of this study was to evaluate the effects of the intra-amniotic administration of a chia phenolic extract on intestinal inflammation, intestinal barrier, brush border membrane functionality, intestinal microbiota, and morphology in vivo (Gallus gallus model). Cornish-cross fertile broiler eggs, at 17 days of embryonic incubation, were separated into groups as follows: non-injected (NI; this group did not receive an injection); 18 MΩ H2O (H2O; injected with ultrapure water), and 10 mg/mL (1%) chia phenolic extract (CPE; injected with phenolic extract diluted in ultrapure water). Immediately after hatch (21 days), chickens were euthanized and their small intestine, cecum, and cecum content were collected and analyzed. The chia phenolic extract reduced the tumor necrosis factor-alpha (TNF-α) and increased the sucrose isomaltase (SI) gene expression, reduced the Bifidobacterium and E. coli populations, reduced the Paneth cell diameter, increased depth crypt, and maintained villus height compared to the non-injected control group. Chia phenolic extract may be a promising beneficial compound for improving intestinal health, demonstrating positive changes in intestinal inflammation, functionality, microbiota, and morphology. Full article
(This article belongs to the Special Issue Anti-inflammatory and Anti-obesity Properties of Food Bioactive Components)
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Graphical abstract

17 pages, 3436 KiB  
Article
Intra-Amniotic Administration of Cashew Nut (Anacardium occidentale L.) Soluble Extract Improved Gut Functionality and Morphology In Vivo (Gallus gallus)
by Talitha Silva Meneguelli, Nikolai Kolba, Arundhati Misra, Ana Paula Dionísio, Ana Claudia Pelissari Kravchychyn, Bárbara Pereira Da Silva, Hercia Stampini Duarte Martino, Helen Hermana Miranda Hermsdorff and Elad Tako
Nutrients 2023, 15(10), 2378; https://doi.org/10.3390/nu15102378 - 19 May 2023
Cited by 1 | Viewed by 1627
Abstract
Cashew nuts are rich in dietary fibers, monounsaturated fatty acids, carotenoids, tocopherols, flavonoids, catechins, amino acids, and minerals that offer benefits for health. However, the knowledge of its effect on gut health is lacking. In this way, cashew nut soluble extract (CNSE) was [...] Read more.
Cashew nuts are rich in dietary fibers, monounsaturated fatty acids, carotenoids, tocopherols, flavonoids, catechins, amino acids, and minerals that offer benefits for health. However, the knowledge of its effect on gut health is lacking. In this way, cashew nut soluble extract (CNSE) was assessed in vivo via intra-amniotic administration in intestinal brush border membrane (BBM) morphology, functionality, and gut microbiota. Four groups were evaluated: (1) no injection (control); (2) H2O injection (control); (3) 10 mg/mL CNSE (1%); and (4) 50 mg/mL CNSE (5%). Results related to CNSE on duodenal morphological parameters showed higher Paneth cell numbers, goblet cell (GC) diameter in crypt and villi, depth crypt, mixed GC per villi, and villi surface area. Further, it decreased GC number and acid and neutral GC. In the gut microbiota, treatment with CNSE showed a lower abundance of Bifidobacterium, Lactobacillus, and E. coli. Further, in intestinal functionality, CNSE upregulated aminopeptidase (AP) gene expression at 5% compared to 1% CNSE. In conclusion, CNSE had beneficial effects on gut health by improving duodenal BBM functionality, as it upregulated AP gene expression, and by modifying morphological parameters ameliorating digestive and absorptive capacity. For intestinal microbiota, higher concentrations of CNSE or long-term intervention may be necessary. Full article
(This article belongs to the Special Issue Anti-inflammatory and Anti-obesity Properties of Food Bioactive Components)
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