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Nutrition and Inflammatory Bowel Disease (IBD)
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Nutrition and Inflammatory Bowel Disease (IBD)

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 33130

Special Issue Editor

Prof. Ece A. Mutlu

E-Mail Website
Guest Editor
Rush Univ, Med Ctr, Sect Gastroenterol Hepatol & Nutr, Chicago, IL 60612 USA
Interests: inflammatory bowel disease; nutrition; microbiome

Special Issue Information

Dear Colleagues,

Inflammatory bowel diseases are chronic debilitating illnesses of the gastrointestinal tract, for which there are no cures. Many patients use dietary therapies and interventions to manage the disease, yet there is relatively little information about best practices and outcomes of dietary interventions for IBD. This Issue seeks original research, narrative and systematic reviews, and meta-analyses that inform about the role of diet and nutritional interventions in the management of IBD patients. Outcomes studied in terms of IBD can be varied, such as the impact of diet on the microbiome, disease flares, responses to medications, etc. Studies pertaining to the role of dietary supplements, vitamins, or trace element deficiencies are also encouraged, along with manuscripts that investigate specific dietary interventions such as the specific carbohydrate diet. Elimination diets are of particular interest, as well as those investigating other dietary and IBD variables.

Prof. Ece A. Mutlu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Inflammatory bowel disease
  • Crohn’s disease
  • Ulcerative colitis
  • Dietary interventions
  • Nutrition
  • Dietary supplements
  • Specific carbohydrate diet
  • Enteral nutrition
  • Vitamin deficiencies.

Published Papers (7 papers)

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Research

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15 pages, 1980 KiB  
Article
Dietary Red Meat Adversely Affects Disease Severity in a Pig Model of DSS-Induced Colitis Despite Reduction in Colonic Pro-Inflammatory Gene Expression
by Tina S. Nielsen, Marlene Fredborg, Peter K. Theil, Yuan Yue, Lærke V. Bruhn, Vibeke Andersen and Stig Purup
Nutrients 2020, 12(6), 1728; https://doi.org/10.3390/nu12061728 - 9 Jun 2020
Cited by 9 | Viewed by 3769
Abstract
Diet plays a substantial role in the pathogenesis and management of ulcerative colitis (UC), and epidemiologic studies indicate an association between red meat intake and increased risk of UC development. Therefore, we evaluated the effect of a red meat diet on dextran sulfate [...] Read more.
Diet plays a substantial role in the pathogenesis and management of ulcerative colitis (UC), and epidemiologic studies indicate an association between red meat intake and increased risk of UC development. Therefore, we evaluated the effect of a red meat diet on dextran sulfate sodium (DSS)-induced colitis in pigs. Weaned pigs (42 days old) were fed either a control diet or a diet substituted with 15% minced, cooked and dried beef from experimental day 0 to 14. From day 14 to 18, half of the pigs on each diet received a daily oral dose of DSS. Dietary red meat aggravated the severity of colitis based on clinical signs of disease (negative performance score) and histopathological parameters in the colon such as erosion/ulceration and the overall inflammation score but no negative effects were observed on systemic health or small intestinal permeability. Importantly, dietary meat also caused a potential beneficial reduction in the colonic expression of the pro-inflammatory cytokines IL-17A and IL-6, the pro-inflammatory enzyme PTGS2 and in the chemokine IL-8. The present study emphasizes the potential of diet to modulate mucosal inflammation and that a red meat diet might be a risk factor for the development of inflammatory bowel disease. Full article
(This article belongs to the Special Issue Nutrition and Inflammatory Bowel Disease (IBD))
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12 pages, 968 KiB  
Article
Association between Health-Related Quality of Life and Nutritional Status in Adult Patients with Crohn’s Disease
by Iolanda Cioffi, Nicola Imperatore, Olivia Di Vincenzo, Lidia Santarpia, Antonio Rispo, Maurizio Marra, Anna Testa, Franco Contaldo, Fabiana Castiglione and Fabrizio Pasanisi
Nutrients 2020, 12(3), 746; https://doi.org/10.3390/nu12030746 - 11 Mar 2020
Cited by 16 | Viewed by 3094
Abstract
This study aimed to assess health related quality of life (HRQoL) in adult patients with Crohn’s disease (CD), considering disease severity and gender differences, and also its relationship with nutritional status. Consecutive adult patients aged 18–65 years with CD were recruited. Disease activity [...] Read more.
This study aimed to assess health related quality of life (HRQoL) in adult patients with Crohn’s disease (CD), considering disease severity and gender differences, and also its relationship with nutritional status. Consecutive adult patients aged 18–65 years with CD were recruited. Disease activity was clinically defined by the Crohn’s Disease Activity Index (CDAI) in active and quiescent phases. HRQoL was evaluated using the validated short form (SF)-36 questionnaire for the Italian population. Additionally, anthropometry, bioimpedance analysis, and handgrip-strength (HGS) were performed. Findings showed that 135 patients (79 men and 56 women) were included, having a mean age of 38.8 ± 14 years and a BMI of 23.2 ± 3.7 kg/m2. Overall, active CD patients had a lower perception of their QoL compared to those clinically quiescent, while gender differences emerged mostly in the quiescent group. Interestingly, HRQoL was significantly associated with many nutritional variables, and muscle strength was the main predictor. Therefore, HRQoL is perceived lower in active compared to quiescent patients, but women experienced poorer QoL than men, especially in the quiescent phase. Finally, higher QoL scores were found in subjects being in clinical remission phase with a preserved muscle function. However, further studies are still required to verify these findings. Full article
(This article belongs to the Special Issue Nutrition and Inflammatory Bowel Disease (IBD))
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16 pages, 2608 KiB  
Article
Researching New Therapeutic Approaches for Abdominal Visceral Pain Treatment: Preclinical Effects of an Assembled System of Molecules of Vegetal Origin
by Carmen Parisio, Elena Lucarini, Laura Micheli, Alessandra Toti, Lorenzo Di Cesare Mannelli, Giulia Antonini, Elena Panizzi, Anna Maidecchi, Emiliano Giovagnoni, Jacopo Lucci and Carla Ghelardini
Nutrients 2020, 12(1), 22; https://doi.org/10.3390/nu12010022 - 20 Dec 2019
Cited by 15 | Viewed by 5158
Abstract
Abdominal pain is a frequent symptom of irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBDs). Although the knowledge of these pathologies is progressing, new therapeutic strategies continue to be investigated. In the present study, the effect of a system of molecules of [...] Read more.
Abdominal pain is a frequent symptom of irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBDs). Although the knowledge of these pathologies is progressing, new therapeutic strategies continue to be investigated. In the present study, the effect of a system of molecules of natural origin (a medical device according to EU Directive 93/42/EC, engineered starting from Boswellia serrata resins, Aloe vera polysaccharides and Matricaria chamomilla and Melissa officinalis polyphenols) was evaluated against the intestinal damage and visceral pain development in DNBS-induced colitis model in rats. The system (250 and 500 mg kg−1) was orally administered once daily, starting three days before the injection of 2,4-dinitrobenzenesulfonic acid (DNBS) and for 14 days thereafter. The viscero-motor response (VMR) to colon-rectal balloon distension (CRD) was used as measure of visceral sensitivity. The product significantly reduced the VMR of DNBS-treated animals. Its effect on pain threshold was better than dexamethasone and mesalazine, and not lower than amitriptyline and otilonium bromide. At microscopic and macroscopic level, the tested system was more effective in protecting the intestinal mucosa than dexamethasone and mesalazine, promoting the healing of tissue lesions. Therefore, we suggest that the described system of molecules of natural origin may represent a therapeutic option to manage painful bowel diseases. Full article
(This article belongs to the Special Issue Nutrition and Inflammatory Bowel Disease (IBD))
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9 pages, 1141 KiB  
Article
Nutritional Assessment in Inflammatory Bowel Disease (IBD)—Development of the Groningen IBD Nutritional Questionnaires (GINQ)
by Vera Peters, Behrooz Z Alizadeh, Jeanne HM de Vries, Gerard Dijkstra and Marjo JE Campmans-Kuijpers
Nutrients 2019, 11(11), 2739; https://doi.org/10.3390/nu11112739 - 12 Nov 2019
Cited by 9 | Viewed by 6839
Abstract
Diet plays a key role in the complex etiology and treatment of inflammatory bowel disease (IBD). Most existing nutritional assessment tools neglect intake of important foods consumed or omitted specifically by IBD patients or incorporate non-Western dietary habits, making the development of appropriate [...] Read more.
Diet plays a key role in the complex etiology and treatment of inflammatory bowel disease (IBD). Most existing nutritional assessment tools neglect intake of important foods consumed or omitted specifically by IBD patients or incorporate non-Western dietary habits, making the development of appropriate dietary guidelines for (Western) IBD patients difficult. Hence, we developed a food frequency questionnaire (FFQ), the Groningen IBD Nutritional Questionnaires (GINQ-FFQ); suitable to assess dietary intake in IBD patients. To develop the GINQ-FFQ, multiple steps were taken, including: identification of IBD specific foods, a literature search, and evaluation of current dietary assessment methods. Expert views were collected and in collaboration with Wageningen University, division of Human Nutrition and Health, this semi-quantitative FFQ was developed using standard methods to obtain a valid questionnaire. Next, the GINQ-FFQ was digitized into a secure web-based environment which also embeds additional nutritional and IBD related questions. The GINQ-FFQ is an online self-administered FFQ evaluating dietary intake, taking the previous month as a reference period. It consists of 121 questions on 218 food items. This paper describes the design process of the GINQ-FFQ which assesses dietary intake especially (but not exclusively) in IBD patients. Validation of the GINQ-FFQ is needed and planned in the near future. Full article
(This article belongs to the Special Issue Nutrition and Inflammatory Bowel Disease (IBD))
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15 pages, 646 KiB  
Article
Analysis of the Nutrients and Food Products Intake of Polish Males with Ulcerative Colitis in Remission
by Dominika Głąbska, Dominika Guzek and Gustaw Lech
Nutrients 2019, 11(10), 2333; https://doi.org/10.3390/nu11102333 - 1 Oct 2019
Cited by 15 | Viewed by 3249
Abstract
In spite of the lack of evidence of diet therapy efficacy to sustain remission of ulcerative colitis (UC), the dietary counseling may be beneficial, as a number of patients restrict intake of some products with no medical consultation. The aim of the present [...] Read more.
In spite of the lack of evidence of diet therapy efficacy to sustain remission of ulcerative colitis (UC), the dietary counseling may be beneficial, as a number of patients restrict intake of some products with no medical consultation. The aim of the present study was to analyze the nutrients and food products intake of Polish males with UC in remission in comparison with a control group. The UC group of 44 male patients with the confirmed remission, as well as the pair-matched group of 44 male controls, matched by their age and concurrent diseases, was recruited for the study. Their dietary intake was assessed based on three-day dietary records (to analyze the nutrients and food products intake) and information about food products excluded from their diet, and compared between respondents. It was observed that the intake of food products did not differ between the compared groups, except for the intake of potatoes and sugar, which was higher (p = 0.0033, p = 0.0092, respectively) in UC patients (median of 209 g and 11 g, respectively) than the control males (median of 100 g and 1 g, respectively). However, it did not influence differences of energy value and nutrients intake between groups, except for the intake of lactose and vitamin B2 per 1000 kcal, which was lower (p = 0.0425, p = 0.0444, respectively) in UC patients (median of 1.8 g and 0.7 g/1000 kcal) than the control males (median of 3.6 g and 0.8 g/1000 kcal). It was observed that the differences in food products intake between the UC individuals in remission and healthy controls were only minor and did not contribute to any significant differences in their nutrients intake. It was concluded that UC patients should be educated not only about the potential influence of food products on their well-being but also about healthy diet recommendations. Full article
(This article belongs to the Special Issue Nutrition and Inflammatory Bowel Disease (IBD))
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17 pages, 1951 KiB  
Article
Protective Effect of Spirulina platensis Extract against Dextran-Sulfate-Sodium-Induced Ulcerative Colitis in Rats
by Mohamed A. Morsy, Sumeet Gupta, Anroop B. Nair, Katharigatta N. Venugopala, Khaled Greish and Mahmoud El-Daly
Nutrients 2019, 11(10), 2309; https://doi.org/10.3390/nu11102309 - 29 Sep 2019
Cited by 24 | Viewed by 4512
Abstract
Inflammatory bowel disease is a multifactorial inflammatory condition. This study aimed to test the protective effects of Spirulina platensis against ulcerative colitis (UC). UC was induced in thirty-six male Wistar rats by adding dextran sulfate sodium (DSS) to their drinking water, while a [...] Read more.
Inflammatory bowel disease is a multifactorial inflammatory condition. This study aimed to test the protective effects of Spirulina platensis against ulcerative colitis (UC). UC was induced in thirty-six male Wistar rats by adding dextran sulfate sodium (DSS) to their drinking water, while a control group received only drinking water. UC rats were equally-divided into six groups that received a single oral daily dose of vehicle (DSS), sulfasalazine (SSZ, 50 mg/kg/day), chloroform or the hydroalcoholic extracts of Spirulina platensis (100 or 200 mg/kg/day) for 15 days, and then blood and colon samples were harvested for determination of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR), myeloperoxidase (MPO), and histopathology. At the end of the study, compared to time-matched controls, UC rats showed increased TNF-α (1.64-fold), IL-6 (5.73-fold), ESR (3.18-fold), and MPO (1.61-fold), along with loss of body weight (24.73%) and disease activity index (1.767 ± 0.216 vs. 0 ± 0), p < 0.001. These effects were prevented by SSZ treatment (p < 0.001 vs. DSS). The hydroalcoholic extract of Spirulina platensis dose-dependently modulated all DSS-induced inflammatory changes. However, the chloroform extract significantly lowered only IL-6 and ESR, but not TNF-α or MPO levels. The protective effects of the hydroalcoholic extract of Spirulina platensis against experimental UC involved mitigation of DSS-induced inflammation. Full article
(This article belongs to the Special Issue Nutrition and Inflammatory Bowel Disease (IBD))
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Review

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14 pages, 269 KiB  
Review
The Rundown of Dietary Supplements and Their Effects on Inflammatory Bowel Disease—A Review
by Bartosz Malinowski, Michał Wiciński, Maya M. Sokołowska, Nicholas A. Hill and Monika Szambelan
Nutrients 2020, 12(5), 1423; https://doi.org/10.3390/nu12051423 - 14 May 2020
Cited by 20 | Viewed by 6059
Abstract
Inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, are a life-long, chronic, and relapsing problem affecting 11.2 million people worldwide. To date, there is pharmacological therapy to treat symptoms such as diarrhea, constipation, and abdominal cramping/pain. These medications also help to alleviate [...] Read more.
Inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, are a life-long, chronic, and relapsing problem affecting 11.2 million people worldwide. To date, there is pharmacological therapy to treat symptoms such as diarrhea, constipation, and abdominal cramping/pain. These medications also help to alleviate everyday discomfort; however, there are no curative therapies. Recent studies have investigated the combination of pharmacological treatment along with nutritional interventions to improve quality of life and risk of disease relapse. Dietary supplements, specifically probiotics, polyphenols, fibers, fatty acids and low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol diets (FODMAP diets), have been closely looked at to determine their effect, if any, on the development of inflammatory bowel disease and its course of progression. Approximately 30 studies were carefully reviewed and analyzed to appreciate the value of these above-mentioned supplements and their influence on this gastrointestinal disease. After analysis, it has been demonstrated that by implementing fibers, polyphenols, and fatty acids, as well as keeping a low-saccharide diet for those patients with Crohn’s disease and ulcerative colitis can improve quality of life and invoke clinical remission. Some polyphenols, specifically curcumin and resveratrol, have proved to decrease disease activity in studies reviewed. Although these studies have become a topic of recent interest, it would be of great value to doctors and patients alike, to continue in this direction of research and to improve the findings for best treatment substances and dosages. This would lead to increased quality of life and disease control leading to fewer complications in the future. Full article
(This article belongs to the Special Issue Nutrition and Inflammatory Bowel Disease (IBD))
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