Submit to Nutrients Review for Nutrients Propose a Special Issue

Journal Browser

► Journal Browser

Diet and Microbiome in Health and Aging

Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Prebiotics and Probiotics".

Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 94897

Printed Edition Available!
A printed edition of this Special Issue is available here.

Special issue Diet and Microbiome in Health and Aging book cover image

Share This Special Issue

Special Issue Editors

Dr. Sonia González

E-Mail Website
Guest Editor

Department of Functional Biology, University of Oviedo, Facultad de Medicina, 33006 Oviedo, Spain
Interests: microbiome; probiotics; prebiotics; diet; polyphenols; fibers; oxidative stress
Special Issues, Collections and Topics in MDPI journals

Dr. Nuria Salazar

E-Mail Website1 Website2
Guest Editor

Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Asturias, Spain.
Interests: Gut microbiome, obesity, Bifidobacterium, probiotics, prebiotics, diet, ageing

Dr. Silvia Arboleya

E-Mail Website1 Website2
Guest Editor

Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Asturias, Spain.
Interests: Gut microbiome, early life, Bifidobacterium, probiotics, prebiotics, diet, gut-brain-axis

Special Issue Information

Dear Colleagues,

Diet plays a fundamental role in shaping the composition and metabolic activity of the gut microbiota and, thus, it could determine the interrelationship between the gut microbiome and the host. The colon is the part of the human body that is most densely populated, containing bacteria, archaea, viruses, and some unicellular eukaryotes that have co-evolved with humans in a commensal way. The gut microbiota plays a crucial role in the maintenance of normal host physiology. The rapid development of next-generation sequencing (NGS) methods for DNA sequencing in the last decade has facilitated in-depth study of gut microbiome composition and function. These methods have contributed to providing evidence regarding the relevance of the intestinal microbiota for host health as well as the basis for putative dietary interventions aimed at counteracting microbiota dysbiosis. Understanding the complex and dynamic interaction between dietary exposures and gut microbiota can help to elucidate their potential role in different pathologies and to guide future strategies for the prevention and treatment of diseases. Age-related changes in the gut microbiome are also associated with physiological changes in the gastrointestinal tract as well as in dietary patterns, with a concomitant decline in the normal function of the immune system that may contribute to increased risk of infection and frailty. More studies are needed to better understand how the microbiota shifts with different environmental factors and how they are associated with dietary changes.

In this Special Issue of Nutrients, we would like to bring together papers dealing with the impact of dietary components on the microbiome in different health outcomes and the aging process. Potential topics may include papers about the possible mechanisms underlying the beneficial actions of probiotics or prebiotics, as well as the interactions between specific nutrients or dietary components and the microbiome. Different types of manuscript submissions, including original research articles and up-to-date reviews (systematic reviews and meta-analyses) were welcome.

Dr. Sonia González
Dr. Nuria Salazar
Dr. Silvia Arboleya
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

probiotics
prebiotics
microbiome
diet
health
aging

Published Papers (14 papers)

Download All Papers

Editorial

Jump to: Research, Review

4 pages, 225 KiB

Open AccessEditorial

Diet and Microbiome in Health and Aging

by Silvia Arboleya, Sonia González and Nuria Salazar

Nutrients 2022, 14(16), 3250; https://doi.org/10.3390/nu14163250 - 9 Aug 2022

Cited by 1 | Viewed by 1997

Abstract

After several years of research, sufficient evidence has been found supporting that diet is one of the main factors able to modulate both composition and activity of the intestinal microbiota, thus positioning it as a cornerstone in the host-microbiota interface [...] Full article

(This article belongs to the Special Issue Diet and Microbiome in Health and Aging)

Research

Jump to: Editorial, Review

13 pages, 1889 KiB

Open AccessArticle

Levels of Predominant Intestinal Microorganisms in 1 Month-Old Full-Term Babies and Weight Gain during the First Year of Life

by Sonia González, Marta Selma-Royo, Silvia Arboleya, Cecilia Martínez-Costa, Gonzalo Solís, Marta Suárez, Nuria Fernández, Clara G. de los Reyes-Gavilán, Susana Díaz-Coto, Pablo Martínez-Camblor, Maria Carmen Collado and Miguel Gueimonde

Nutrients 2021, 13(7), 2412; https://doi.org/10.3390/nu13072412 - 14 Jul 2021

Cited by 9 | Viewed by 2745

Abstract

The early life gut microbiota has been reported to be involved in neonatal weight gain and later infant growth. Therefore, this early microbiota may constitute a target for the promotion of healthy neonatal growth and development with potential consequences for later life. Unfortunately, we are still far from understanding the association between neonatal microbiota and weight gain and growth. In this context, we evaluated the relationship between early microbiota and weight in a cohort of full-term infants. The absolute levels of specific fecal microorganisms were determined in 88 vaginally delivered and 36 C-section-delivered full-term newborns at 1 month of age and their growth up to 12 months of age. We observed statistically significant associations between the levels of some early life gut microbes and infant weight gain during the first year of life. Classifying the infants into tertiles according to their Staphylococcus levels at 1 month of age allowed us to observe a significantly lower weight at 12 months of life in the C-section-delivered infants from the highest tertile. Univariate and multivariate models pointed out associations between the levels of some fecal microorganisms at 1 month of age and weight gain at 6 and 12 months. Interestingly, these associations were different in vaginally and C-section-delivered babies. A significant direct association between Staphylococcus and weight gain at 1 month of life was observed in vaginally delivered babies, whereas in C-section-delivered infants, lower Bacteroides levels at 1 month were associated with higher later weight gain (at 6 and 12 months). Our results indicate an association between the gut microbiota and weight gain in early life and highlight potential microbial predictors for later weight gain. Full article

(This article belongs to the Special Issue Diet and Microbiome in Health and Aging)

► Show Figures

Figure 1

31 pages, 4231 KiB

Open AccessArticle

Application of Ligilactobacillus salivarius CECT5713 to Achieve Term Pregnancies in Women with Repetitive Abortion or Infertility of Unknown Origin by Microbiological and Immunological Modulation of the Vaginal Ecosystem

by Leónides Fernández, Irma Castro, Rebeca Arroyo, Claudio Alba, David Beltrán and Juan M. Rodríguez

Nutrients 2021, 13(1), 162; https://doi.org/10.3390/nu13010162 - 6 Jan 2021

Cited by 16 | Viewed by 4244

Abstract

In this study, the cervicovaginal environment of women with reproductive failure (repetitive abortion, infertility of unknown origin) was assessed and compared to that of healthy fertile women. Subsequently, the ability of Ligilactobacillus salivarius CECT5713 to increase pregnancy rates in women with reproductive failure was evaluated. Vaginal pH and Nugent score were higher in women with reproductive failure than in fertile women. The opposite was observed regarding the immune factors TGF-β 1, TFG-β 2, and VEFG. Lactobacilli were detected at a higher frequency and concentration in fertile women than in women with repetitive abortion or infertility. The metataxonomic study revealed that vaginal samples from fertile women were characterized by the high abundance of Lactobacillus sequences, while DNA from this genus was practically absent in one third of samples from women with reproductive failure. Daily oral administration of L. salivarius CECT5713 (~9 log₁₀ CFU/day) to women with reproductive failure for a maximum of 6 months resulted in an overall successful pregnancy rate of 56%. The probiotic intervention modified key microbiological, biochemical, and immunological parameters in women who got pregnant. In conclusion, L. salivarius CECT5713 has proved to be a good candidate to improve reproductive success in women with reproductive failure. Full article

(This article belongs to the Special Issue Diet and Microbiome in Health and Aging)

► Show Figures

Figure 1

17 pages, 1272 KiB

Open AccessArticle

Comparison of Different Dietary Indices as Predictors of Inflammation, Oxidative Stress and Intestinal Microbiota in Middle-Aged and Elderly Subjects

by Sergio Ruiz-Saavedra, Nuria Salazar, Ana Suárez, Clara G. de los Reyes-Gavilán, Miguel Gueimonde and Sonia González

Nutrients 2020, 12(12), 3828; https://doi.org/10.3390/nu12123828 - 15 Dec 2020

Cited by 22 | Viewed by 4072

Abstract

During the last decades the gut microbiota has been identified as a key mediator in the diet-health interaction. However, our understanding on the impact of general diet upon microbiota is still limited. Dietary indices represent an essential approach for addressing the link between diet and health from a holistic point of view. Our aim was to test the predictive potential of seven dietary ratings on biomarkers of inflammation, oxidative stress and on the composition and metabolic activity of the intestinal microbiota. A cross-sectional descriptive study was conducted on a sample of 73 subjects aged >50 years with non-declared pathologies. Dietary inflammatory index (DII), Empirical Dietary Inflammatory Index (EDII), Healthy Eating Index (HEI), Alternative Healthy Eating Index (AHEI), Mediterranean adapted Diet Quality Index-International (DQI-I), Modified Mediterranean Diet Score (MMDS) and relative Mediterranean Diet Score (rMED) were calculated based on a Food Frequency Questionnaire. Major phylogenetic types of the intestinal microbiota were determined by real time polymerase chain reaction (qPCR) and fecal short chain fatty acids (SCFAs) by gas chromatography. While DII, HEI, DQI-I and MMDS were identified as predictors of Faecalibacterium prausnitzii levels, AHEI and MMDS were negatively associated with Lactobacillus group. HEI, AHEI and MMDS were positively associated with fecal SCFAs. In addition, DII and EDII explained lipoperoxidation level and Mediterranean scores the serum IL-8 concentrations. The lower detection of IL-8 in individuals with higher scores on Mediterranean indices may be partially explained by the increased levels of the anti-inflammatory bacterium F. prausnitzii in such individuals. Full article

(This article belongs to the Special Issue Diet and Microbiome in Health and Aging)

► Show Figures

Figure 1

19 pages, 1362 KiB

Open AccessArticle

Associations between Pro- and Anti-Inflammatory Gastro-Intestinal Microbiota, Diet, and Cognitive Functioning in Dutch Healthy Older Adults: The NU-AGE Study

by Annick P. M. van Soest, Gerben D. A. Hermes, Agnes A. M. Berendsen, Ondine van de Rest, Erwin G. Zoetendal, Susana Fuentes, Aurelia Santoro, Claudio Franceschi, Lisette C. P. G. M. de Groot and Willem M. de Vos

Nutrients 2020, 12(11), 3471; https://doi.org/10.3390/nu12113471 - 12 Nov 2020

Cited by 41 | Viewed by 7460

Abstract

Dietary modulation of the gastro-intestinal microbiota is a potential target in improving healthy ageing and age-related functional outcomes, including cognitive decline. We explored the association between diet, gastro-intestinal microbiota and cognition in Dutch healthy older adults of the ‘New dietary strategies addressing the specific needs of the elderly population for healthy aging in Europe’ (NU-AGE) study. The microbiota profile of 452 fecal samples from 226 subjects was determined using a 16S ribosomal RNA gene-targeted microarray. Dietary intake was assessed by 7-day food records. Cognitive functioning was measured with an extensive cognitive test battery. We observed a dietary and microbial pro- to anti-inflammatory gradient associated with diets richer in animal- or plant-based foods. Fresh fruits, nuts, seeds and peanuts, red and processed meat and grain products were most strongly associated to microbiota composition. Plant-rich diets containing fresh fruits, nuts, seeds and peanuts were positively correlated with alpha-diversity, various taxa from the Bacteroidetes phylum and anti-inflammatory species, including those related to Faecalibacterium prausnitzii and Eubacterium rectale and E. biforme. Animal product-rich diets associated with pro-inflammatory species, including those related to Ruminococcus gnavus and Collinsella spp.. Cognition was neither associated with microbiota composition nor alpha-diversity. In conclusion, diets richer in animal- and plant-based foods were related to a pro- and anti-inflammatory microbial profile, while cognition was associated with neither. Full article

(This article belongs to the Special Issue Diet and Microbiome in Health and Aging)

► Show Figures

Figure 1

18 pages, 2654 KiB

Open AccessFeature PaperArticle

Putative Mechanisms Responsible for the Antihyperglycemic Action of Lactobacillus paracasei HII01 in Experimental Type 2 Diabetic Rats

by Parichart Toejing, Nuntawat Khat-Udomkiri, Jannarong Intakhad, Sasithorn Sirilun, Chaiyavat Chaiyasut and Narissara Lailerd

Nutrients 2020, 12(10), 3015; https://doi.org/10.3390/nu12103015 - 1 Oct 2020

Cited by 24 | Viewed by 3034

Abstract

Despite the updated knowledge of the impact of gut dysbiosis on diabetes, investigations into the beneficial effects of individual bacteria are still required. This study evaluates the antihyperglycemic efficacy of Lactobacillus paracasei HII01 and its possible mechanisms in diabetic rats. Diabetic rats were assigned to receive vehicle, L. paracasei HII01 (10⁸ CFU/day), metformin 30 (mg/kg) or a combination of L. paracasei HII01 and metformin. Normal rats given vehicle and L. paracasei HII01 were included. Metabolic parameters, including in vitro hemi-diaphragm glucose uptake, skeletal insulin-signaling proteins, plasma lipopolysaccharide (LPS), gut permeability, composition of gut microbiota and its metabolites, as well as short-chain fatty acids (SCFAs), were assessed after 12 weeks of experiment. The results clearly demonstrated that L. paracasei HII01 improved glycemic parameters, glucose uptake, insulin-signaling proteins including pAkt^Ser473, glucose transporter 4 (GLUT4) and phosphorylation of AMP-activated protein kinase (pAMPK^Thr172), tumor necrosis factor (TNF-α) and nuclear factor-κB (NF-kB) in diabetic rats. Modulation of gut microbiota was found together with improvement in leaky gut, endotoxemia and SCFAs in diabetic rats administered L. paracasei HII01. In conclusion, L. paracasei HII01 alleviated hyperglycemia in diabetic rats primarily by modulating gut microbiota along with lessening leaky gut, leading to improvement in endotoxemia and inflammation-disturbed insulin signaling, which was mediated partly by PI3K/Akt signaling and AMPK activation. Full article

(This article belongs to the Special Issue Diet and Microbiome in Health and Aging)

► Show Figures

Figure 1

21 pages, 2114 KiB

Open AccessArticle

Whole Blueberry and Isolated Polyphenol-Rich Fractions Modulate Specific Gut Microbes in an In Vitro Colon Model and in a Pilot Study in Human Consumers

by Alexandra Ntemiri, Tarini S. Ghosh, Molly E. Gheller, Tam T. T. Tran, Jamie E. Blum, Paola Pellanda, Klara Vlckova, Marta C. Neto, Amy Howell, Anna Thalacker-Mercer and Paul W. O’Toole

Nutrients 2020, 12(9), 2800; https://doi.org/10.3390/nu12092800 - 12 Sep 2020

Cited by 32 | Viewed by 6581

Abstract

Blueberry (BB) consumption is linked to improved health. The bioconversion of the polyphenolic content of BB by fermentative bacteria in the large intestine may be a necessary step for the health benefits attributed to BB consumption. The identification of specific gut microbiota taxa that respond to BB consumption and that mediate the bioconversion of consumed polyphenolic compounds into bioactive forms is required to improve our understanding of how polyphenols impact human health. We tested the ability of polyphenol-rich fractions purified from whole BB—namely, anthocyanins/flavonol glycosides (ANTH/FLAV), proanthocyanidins (PACs), the sugar/acid fraction (S/A), and total polyphenols (TPP)—to modulate the fecal microbiota composition of healthy adults in an in vitro colon system. In a parallel pilot study, we tested the effect of consuming 38 g of freeze-dried BB powder per day for 6 weeks on the fecal microbiota of 17 women in two age groups (i.e., young and older). The BB ingredients had a distinct effect on the fecal microbiota composition in the artificial colon model. The ANTH/FLAV and PAC fractions were more effective in promoting microbiome alpha diversity compared to S/A and TPP, and these effects were attributed to differentially responsive taxa. Dietary enrichment with BB resulted in a moderate increase in the diversity of the microbiota of the older subjects but not in younger subjects, and certain health-relevant taxa were significantly associated with BB consumption. Alterations in the abundance of some gut bacteria correlated not only with BB consumption but also with increased antioxidant activity in blood. Collectively, these pilot data support the notion that BB consumption is associated with gut microbiota changes and health benefits. Full article

(This article belongs to the Special Issue Diet and Microbiome in Health and Aging)

► Show Figures

Figure 1

17 pages, 3409 KiB

Open AccessArticle

Differences in Gut Microbiome Composition between Senior Orienteering Athletes and Community-Dwelling Older Adults

by Frida Fart, Sukithar Kochappi Rajan, Rebecca Wall, Ignacio Rangel, John Peter Ganda-Mall, Lina Tingö, Robert J. Brummer, Dirk Repsilber, Ida Schoultz and Carl Mårten Lindqvist

Nutrients 2020, 12(9), 2610; https://doi.org/10.3390/nu12092610 - 27 Aug 2020

Cited by 25 | Viewed by 7494

Abstract

Background: Gastrointestinal (GI) health is an important aspect of general health. Gastrointestinal symptoms are of specific importance for the elderly, an increasing group globally. Hence, promoting the elderly’s health and especially gastrointestinal health is important. Gut microbiota can influence gastrointestinal health by modulation of the immune system and the gut–brain axis. Diverse gut microbiota have been shown to be beneficial; however, for the elderly, the gut microbiota is often less diverse. Nutrition and physical activity, in particular, are two components that have been suggested to influence composition or diversity. Materials and Methods: In this study, we compared gut microbiota between two groups of elderly individuals: community-dwelling older adults and physically active senior orienteering athletes, where the latter group has less gastrointestinal symptoms and a reported better well-being. With this approach, we explored if certain gut microbiota were related to healthy ageing. The participant data and faecal samples were collected from these two groups and the microbiota was whole-genome sequenced and taxonomically classified with MetaPhlAn. Results: The physically active senior orienteers had a more homogeneous microbiota within the group and a higher abundance of Faecalibacterium prausnitzii compared to the community-dwelling older adults. Faecalibacterium prausnitzii has previously shown to have beneficial properties. Senior orienteers also had a lower abundance of Parasutterella excrementihominis and Bilophila unclassified, which have been associated with impaired GI health. We could not observe any difference between the groups in terms of Shannon diversity index. Interestingly, a subgroup of community-dwelling older adults showed an atypical microbiota profile as well as the parameters for gastrointestinal symptoms and well-being closer to senior orienteers. Conclusions: Our results suggest specific composition characteristics of healthy microbiota in the elderly, and show that certain components of nutrition as well as psychological distress are not as tightly connected with composition or diversity variation in faecal microbiota samples. Full article

(This article belongs to the Special Issue Diet and Microbiome in Health and Aging)

► Show Figures

Figure 1

16 pages, 2015 KiB

Open AccessArticle

Gut Health-Promoting Benefits of a Dietary Supplement of Vitamins with Inulin and Acacia Fibers in Rats

by Malén Massot-Cladera, Ignasi Azagra-Boronat, Àngels Franch, Margarida Castell, Maria J. Rodríguez-Lagunas and Francisco J. Pérez-Cano

Nutrients 2020, 12(8), 2196; https://doi.org/10.3390/nu12082196 - 23 Jul 2020

Cited by 25 | Viewed by 4366

Abstract

The study’s objective was to ascertain whether a nutritional multivitamin and mineral supplement enriched with two different dietary fibers influences microbiota composition, mineral absorption, and some immune and metabolic biomarkers in adult rats. Nine-week-old Wistar rats were randomly assigned into four groups: the reference group; the group receiving a daily supplement based on a food matrix with proteins, vitamins, and minerals; and two other groups receiving this supplement enriched with inulin (V + I) or acacia (V + A) fiber for four weeks. Microbiota composition was determined in cecal content and mineral content in fecal, blood, and femur samples. Intestinal IgA concentration, hematological, and biochemical variables were evaluated. Both V + I and V + A supplementations increased Firmicutes and Actinobacteria phyla, which were associated with a higher presence of Lactobacillus and Bifidobacterium spp. V + A supplementation increased calcium, magnesium, phosphorus, and zinc concentrations in femur. V + I supplementation increased the fecal IgA content and reduced plasma total cholesterol and uric acid concentration. Both fiber-enriched supplements tested herein seem to be beneficial to gut-health, although differently. Full article

(This article belongs to the Special Issue Diet and Microbiome in Health and Aging)

► Show Figures

Figure 1

11 pages, 1368 KiB

Open AccessArticle

Long-Term Coffee Consumption is Associated with Fecal Microbial Composition in Humans

by Sonia González, Nuria Salazar, Sergio Ruiz-Saavedra, María Gómez-Martín, Clara G. de los Reyes-Gavilán and Miguel Gueimonde

Nutrients 2020, 12(5), 1287; https://doi.org/10.3390/nu12051287 - 1 May 2020

Cited by 56 | Viewed by 13492

Abstract

Coffee consumption has been related to a preventive effect against several non-transmissible pathologies. Due to the content of this beverage in phytochemicals and minerals, it has been proposed that its impact on health may partly depend on gut microbiota modulation. Our aim was to explore the interaction among gut microbiota, fecal short chain fatty acids, and health-related parameters in 147 healthy subjects classified according to coffee consumption, to deepen the association of the role of the (poly)phenol and alkaloid content of this beverage. Food daily intake was assessed by an annual food frequency questionnaire (FFQ). Coffee consumption was categorized into three groups: non-coffee-consumers (0–3 mL/day), moderate consumers (3–45 mL/day) and high-coffee consumers (45–500 mL/day). Some relevant groups of the gut microbiota were determined by qPCR, and concentration of fecal short chain fatty acids by gas chromatography. Serum health related biomarkers were determined by standardized methods. Interestingly, a higher level of Bacteroides–Prevotella–Porphyromonas was observed in the high consumers of coffee, who also had lower levels of lipoperoxidation. Two groups of coffee-derived (poly)phenol, methoxyphenols and alkylphenols, and caffeine, among alkaloids, were directly associated with Bacteroides group levels. Thus, regular consumption of coffee appears to be associated with changes in some intestinal microbiota groups in which dietary (poly)phenol and caffeine may play a role. Full article

(This article belongs to the Special Issue Diet and Microbiome in Health and Aging)

► Show Figures

Figure 1

Review

Jump to: Editorial, Research

18 pages, 327 KiB

Open AccessReview

Prevention and Management with Pro-, Pre and Synbiotics in Children with Asthma and Allergic Rhinitis: A Narrative Review

by Lien Meirlaen, Elvira Ingrid Levy and Yvan Vandenplas

Nutrients 2021, 13(3), 934; https://doi.org/10.3390/nu13030934 - 14 Mar 2021

Cited by 25 | Viewed by 4449

Abstract

Allergic diseases including allergic rhinitis and asthma are increasing in the developing world, related to a westernizing lifestyle, while the prevalence is stable and decreasing in the industrialized world. This paper aims to answer the question if prevention and/or treatment of allergic rhinitis and asthma can be achieved by administrating pro-, pre- and/or synbiotics that might contribute to stabilizing the disturbed microbiome that influences the immune system through the gut–lung axis. We searched for relevant English articles in PubMed and Google Scholar. Articles interesting for the topic were selected using subject heading and key words. Interesting references in included articles were also considered. While there is substantial evidence from animal studies in well controlled conditions that selected probiotic strains may offer benefits in the prevention of wheezing and asthma, outcomes from clinical studies in infants (including as well pre- and postnatal administration) are disappointing. The latter may be related to the multiple confounding factors such as environment, strain selection and dosage, moment of administration and genetic background. There is little evidence to recommend administration of pro, pre- or synbiotics in the prevention of asthma and allergic rhinitis in children. Full article

(This article belongs to the Special Issue Diet and Microbiome in Health and Aging)

24 pages, 1862 KiB

Open AccessReview

The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame?

by Ashwinipriyadarshini Megur, Daiva Baltriukienė, Virginija Bukelskienė and Aurelijus Burokas

Nutrients 2021, 13(1), 37; https://doi.org/10.3390/nu13010037 - 24 Dec 2020

Cited by 133 | Viewed by 16544

Abstract

For years, it has been reported that Alzheimer’s disease (AD) is the most common cause of dementia. Various external and internal factors may contribute to the early onset of AD. This review highlights a contribution of the disturbances in the microbiota–gut–brain (MGB) axis to the development of AD. Alteration in the gut microbiota composition is determined by increase in the permeability of the gut barrier and immune cell activation, leading to impairment in the blood–brain barrier function that promotes neuroinflammation, neuronal loss, neural injury, and ultimately AD. Numerous studies have shown that the gut microbiota plays a crucial role in brain function and changes in the behavior of individuals and the formation of bacterial amyloids. Lipopolysaccharides and bacterial amyloids synthesized by the gut microbiota can trigger the immune cells residing in the brain and can activate the immune response leading to neuroinflammation. Growing experimental and clinical data indicate the prominent role of gut dysbiosis and microbiota–host interactions in AD. Modulation of the gut microbiota with antibiotics or probiotic supplementation may create new preventive and therapeutic options in AD. Accumulating evidences affirm that research on MGB involvement in AD is necessary for new treatment targets and therapies for AD. Full article

(This article belongs to the Special Issue Diet and Microbiome in Health and Aging)

► Show Figures

Figure 1

25 pages, 826 KiB

Open AccessReview

A Revolutionizing Approach to Autism Spectrum Disorder Using the Microbiome

by Dinyadarshini Johnson, Vengadesh Letchumanan, Sivakumar Thurairajasingam and Learn-Han Lee

Nutrients 2020, 12(7), 1983; https://doi.org/10.3390/nu12071983 - 3 Jul 2020

Cited by 33 | Viewed by 10417

Abstract

The study of human microbiota and health has emerged as one of the ubiquitous research pursuits in recent decades which certainly warrants the attention of both researchers and clinicians. Many health conditions have been linked to the gut microbiota which is the largest reservoir of microbes in the human body. Autism spectrum disorder (ASD) is one of the neurodevelopmental disorders which has been extensively explored in relation to gut microbiome. The utilization of microbial knowledge promises a more integrative perspective in understanding this disorder, albeit being an emerging field in research. More interestingly, oral and vaginal microbiomes, indicating possible maternal influence, have equally drawn the attention of researchers to study their potential roles in the etiopathology of ASD. Therefore, this review attempts to integrate the knowledge of microbiome and its significance in relation to ASD including the hypothetical aetiology of ASD and its commonly associated comorbidities. The microbiota-based interventions including diet, prebiotics, probiotics, antibiotics, and faecal microbial transplant (FMT) have also been explored in relation to ASD. Of these, diet and probiotics are seemingly promising breakthrough interventions in the context of ASD for lesser known side effects, feasibility and easier administration, although more studies are needed to ascertain the actual clinical efficacy of these interventions. The existing knowledge and research gaps call for a more expanded and resolute research efforts in establishing the relationship between autism and microbiomes. Full article

(This article belongs to the Special Issue Diet and Microbiome in Health and Aging)

► Show Figures

Graphical abstract

19 pages, 1670 KiB

Open AccessReview

The Impact of Diet on Microbiota Evolution and Human Health. Is Diet an Adequate Tool for Microbiota Modulation?

by Laura Moles and David Otaegui

Nutrients 2020, 12(6), 1654; https://doi.org/10.3390/nu12061654 - 2 Jun 2020

Cited by 37 | Viewed by 6673

Abstract

The human microbiome is emerging as an interesting field in research into the prevention of health problems and recovery from illness in humans. The complex ecosystem formed by the microbiota is continuously interacting with its host and the environment. Diet could be assumed to be one of the most prominent factors influencing the microbiota composition. Nevertheless, and in spite of numerous strategies proposed to modulate the human microbiota through dietary means, guidelines to achieve this goal have yet to be established. This review assesses the correlation between social and dietary changes over the course of human evolution and the adaptation of the human microbiota to those changes. In addition, it discusses the main dietary strategies for modulating the microbiota and the difficulties of putting them properly into practice. Full article

(This article belongs to the Special Issue Diet and Microbiome in Health and Aging)

► Show Figures

Figure 1

Journal Menu

Journal Browser

Diet and Microbiome in Health and Aging

Share This Special Issue

Special Issue Editors

Special Issue Information

Keywords

Published Papers (14 papers)

Editorial

Research

Review

Further Information

Guidelines

MDPI Initiatives

Follow MDPI