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A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: closed (15 March 2020) | Viewed by 24758

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Prof. Dr. Aalt Bast

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Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Health Sciences, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
Interests: pharmacology; nutrition; toxicology; pharmacy; medical and pharmaceutical chemistry; drug development; drug metabolism; drug safety; pharmacotherapy; food supplements; reactive oxygen species; free radicals; antioxidants; oxidative stress; redox modulation; flavonoids; thiols; glutathione; reactive intermediates; lipid peroxidation; kinetics; structure activity relationship; biomarkers; regulatory issues; food safety
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Dear Colleagues,

Given the definition of health from 1948 as ‘A state of complete physical, social and mental well-being’, a crucial role in addressing this was assigned to selectively acting drugs. Currently, a more dynamic definition for health is used, viz., ‘the ability to adapt’. In this concept of health, nutrition is strongly involved. Cures by drugs has changed into prevention by nutrition. Molecular targets have also changed. Drugs primarily act via a specific single target whereas nutrition acts via multiple targets. The specific pharmacological effects of drugs are large while the broad multitude of the physiological effects of nutrition is more subtle. At the same time, it has been recognized that in combining both drugs and nutrition, serious interactions may occur. Drugs can influence the uptake of certain nutrients and, vice versa, nutrition influences the uptake, elimination, and action of drugs.

This Special Issue, ‘Drug–Nutrition Interactions’ welcomes manuscripts showing that not only can the action of drugs be modified by nutrition but, also, the side effects of drugs may be mitigated by nutrition. New examples of the influence of drugs on nutrient uptake and/or elimination are also welcomed.

Prof. Dr. Aalt Bast
Guest Editor

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

drugs
nutrition
interaction
mechanism
clinical relevance
polyphenols
toxicity
food supplements

Published Papers (6 papers)

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Research

15 pages, 1200 KiB

Open AccessArticle

Effects of Monomeric and Oligomeric Flavanols on Kidney Function, Inflammation and Oxidative Stress in Runners: A Randomized Double-Blind Pilot Study

by Khrystyna O. Semen, Antje R. Weseler, Marcel J. W. Janssen, Marie-José Drittij-Reijnders, Jos L. M. L. le Noble and Aalt Bast

Nutrients 2020, 12(6), 1634; https://doi.org/10.3390/nu12061634 - 01 Jun 2020

Cited by 3 | Viewed by 3366

Abstract

Nonsteroidal anti-inflammatory drugs are frequently used by athletes in order to prevent musculoskeletal pain and improve performance. In combination with strenuous exercise, they can contribute to a reduction of renal blood flow and promote development of kidney damage. We aimed to investigate whether monomeric and oligomeric flavanols (MOF) could reduce the severity of kidney injuries associated with the intake of 400-mg ibuprofen followed by the completion of a half-marathon in recreational athletes. In this double-blind, randomized study, the original MOF blend of extracts from grape seeds (Vitis vinifera L.) and pine bark (Pinus pinaster L.) or placebo were taken for 14 days preceding the ibuprofen/half-marathon. Urine samples were collected before and after the ibuprofen/half-marathon, and biomarkers of kidney injury, inflammation and oxidative stress were assessed. Intake of MOF significantly reduced the incidence of post-race hematuria (p = 0.0004) and lowered concentrations of interleukin (IL)-6 in the urine (p = 0.032). Urinary neutrophil-associated lipocalin, creatine, albumin, IL-8 and malondialdehyde tended to decrease. The supplementation with MOF in recreational runners appears to safely preserve kidney function, reduce inflammation and promote antioxidant defense during strenuous exercise and intake of a single dose of ibuprofen. Full article

(This article belongs to the Special Issue Drug-Nutrition Interactions)

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15 pages, 2810 KiB

Open AccessArticle

Cytoprotective Effect of Ascorbic Acid and Rutin against Oxidative Changes in the Proteome of Skin Fibroblasts Cultured in a Three-Dimensional System

by Agnieszka Gęgotek, Iwona Jarocka-Karpowicz and Elżbieta Skrzydlewska

Nutrients 2020, 12(4), 1074; https://doi.org/10.3390/nu12041074 - 13 Apr 2020

Cited by 28 | Viewed by 3040

Abstract

The combination of ascorbic acid and rutin, commonly used in oral preparations for their antioxidant and anti-inflammatory properties, can also be used to protect skin cells from the effects of UV radiation in sunlight. Here, we tested the potential protective effect of ascorbic acid and rutin used together in UVB-irradiated human skin fibroblasts, and assessed the proteomic profile of these cells, grown in a three-dimensional (3D) system. Proteomic findings revealed a combined effect of ascorbic acid and rutin in UV-irradiated fibroblasts against overexpression of pro-inflammatory signaling proteins and DNA reorganization/expression. These effects were not observed when cells were treated with either compounds alone. The antioxidant effects of ascorbic acid and rutin also prevented protein modifications by lipid peroxidation products. Further, ascorbic acid stimulated rutin-protein adduct formation, which supports intra/extracellular signaling and the Nrf2/ARE antioxidant pathway, contributing to the protective effects against UV-induced oxidative stress. The combined effect of ascorbic acid and rutin suggests that this combination of compounds is potentially effective against skin damage caused by UV radiation. Full article

(This article belongs to the Special Issue Drug-Nutrition Interactions)

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20 pages, 1731 KiB

Open AccessArticle

Ethanolic Extract of Moringa oleifera Leaves Influences NF-κB Signaling Pathway to Restore Kidney Tissue from Cobalt-Mediated Oxidative Injury and Inflammation in Rats

by Mohamed M. Abdel-Daim, Samah R. Khalil, Ashraf Awad, Ehsan H. Abu Zeid, Reda Abd El-Aziz and Hamed A. El-Serehy

Nutrients 2020, 12(4), 1031; https://doi.org/10.3390/nu12041031 - 09 Apr 2020

Cited by 41 | Viewed by 5935

Abstract

This study aimed to describe the protective efficacy of Moringa oleifera ethanolic extract (MOEE) against the impact of cobalt chloride (CoCl₂) exposure on the rat’s kidney. Fifty male rats were assigned to five equal groups: a control group, a MOEE-administered group (400 mg/kg body weight (bw), daily via gastric tube), a CoCl₂-intoxicated group (300 mg/L, daily in drinking water), a protective group, and a therapeutic co-administered group that received MOEE prior to or following and concurrently with CoCl₂, respectively. The antioxidant status indices (superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH)), oxidative stress markers (hydrogen peroxide (H₂O₂), 8-hydroxy-2-deoxyguanosine (8-OHdG), and malondialdehyde (MDA)), and inflammatory response markers (nitric oxide (NO), tumor necrosis factor (TNF-α), myeloperoxidase (MPO), and C-reactive protein (CRP)) were evaluated. The expression profiles of pro-inflammatory cytokines (nuclear factor-kappa B (NF-kB) and interleukin-6 (IL-6)) were also measured by real-time quantitative polymerase chain reaction (qRT-PCR). The results showed that CoCl₂ exposure was associated with significant elevations of oxidative stress and inflammatory indices with reductions in the endogenous tissue antioxidants’ concentrations. Moreover, CoCl₂ enhanced the activity of the NF-κB inflammatory-signaling pathway that plays a role in the associated inflammation of the kidney. MOEE ameliorated CoCl₂-induced renal oxidative damage and inflammatory injury with the suppression of the mRNA expression pattern of pro-inflammatory cytokine-encoding genes. MOEE is more effective when it is administered with CoCl₂ exposure as a prophylactic regimen. In conclusion, MOEE administration exhibited protective effects in counteracting CoCl₂-induced renal injury in rats. Full article

(This article belongs to the Special Issue Drug-Nutrition Interactions)

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12 pages, 2554 KiB

Open AccessArticle

Dietary Advanced Glycation Endproducts Decrease Glucocorticoid Sensitivity In Vitro

by Timme van der Lugt, Antje R. Weseler, Misha F. Vrolijk, Antoon Opperhuizen and Aalt Bast

Nutrients 2020, 12(2), 441; https://doi.org/10.3390/nu12020441 - 10 Feb 2020

Cited by 10 | Viewed by 3077

Abstract

Glucocorticoids are very effective anti-inflammatory drugs and widely used for inflammatory bowel disease (IBD) patients. However, approximately 20% of IBD patients do not respond to glucocorticoids and the reason for this is largely unknown. Dietary advanced glycation endproducts (AGEs) are formed via the Maillard reaction during the thermal processing of food products and can induce a pro-inflammatory reaction in human cells. To investigate whether this pro-inflammatory response could be mitigated by glucocorticoids, human macrophage-like cells were exposed to both LPS and AGEs to induce interleukin-8 (IL8) secretion. This pro-inflammatory response was then modulated by adding pharmacological compounds interfering in different steps of the anti-inflammatory mechanism of glucocorticoids: rapamycin, quercetin, and theophylline. Additionally, intracellular reactive oxygen species (ROS) were measured and the glucocorticoid receptor phosphorylation state was assessed. The results show that AGEs induced glucocorticoid resistance, which could be mitigated by quercetin and rapamycin. No change in the phosphorylation state of the glucocorticoid receptor was observed. Additionally, intracellular ROS formation was induced by AGEs, which was mitigated by quercetin. This suggests that AGE-induced ROS is an underlying mechanism to AGE-induced glucocorticoid resistance. This study shows for the first time the phenomenon of dietary AGE-induced glucocorticoid resistance due to the formation of ROS. Our findings indicate that food products with a high inflammatory potential can induce glucocorticoid resistance; these results may be of great importance to IBD patients suffering from glucocorticoid resistance. Full article

(This article belongs to the Special Issue Drug-Nutrition Interactions)

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14 pages, 2970 KiB

Open AccessArticle

High Dietary Kuding Tea Extract Supplementation Induces Hepatic Xenobiotic-Metabolizing Enzymes—A 6-Week Feeding Study in Mice

by Svenja Wüpper, Alexandra Fischer, Kai Lüersen, Ralph Lucius, Hinako Okamoto, Yoshiyuki Ishida, Keiji Terao and Gerald Rimbach

Nutrients 2020, 12(1), 40; https://doi.org/10.3390/nu12010040 - 22 Dec 2019

Cited by 10 | Viewed by 5613

Abstract

Kuding tea (KT) is a traditional Chinese beverage rich in plant bioactives that may exhibit various health benefits. However, little is known about the safety of KT extract (KTE) when consumed long term at high doses as a dietary supplement. Therefore, in this study, we investigated aspects of the safety of KTE. Male C57BL/6 mice were fed a high-fat, high-fructose, Western-type diet (control) supplemented with either 12.88% γ-cyclodextrin (γCD), 7.12% KTE (comprising 0.15% ursolic acid, UA) encapsulated in 12.88% γCD (KTE-γCD), or 0.15% UA over a 6-week experimental period. The dietary treatments did not affect food intake, body weight or body composition. However, treatment with KTE-γCD, but not γCD and UA, increased liver weight and hepatic fat accumulation, which was accompanied by increased hepatic PPARγ and CD36 mRNA levels. KTE-γCD treatment elevated plasma cholesterol and CYP7A1 mRNA and protein levels compared to those in control mice. KTE-γCD substantially increased the mRNA and protein levels of hepatic CYP3A and GSTA1, which are central to the detoxification of drugs and xenobiotics. Furthermore, we observed a moderate elevation in hepatic CYP3A (5-fold change) and GSTA1 (1.7-fold change) mRNA levels in UA-fed mice. In vitro data collected in HepG2 cells indicated a dose-dependent increase in hepatic cytotoxicity in response to KTE treatment, which may have been partly mediated by UA. Overall, the present data may contribute to the safety assessment of KTE and suggest that KTE encapsulated in γCD affects liver fat storage and the hepatic phase I and phase II responses in mice. Full article

(This article belongs to the Special Issue Drug-Nutrition Interactions)

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15 pages, 1841 KiB

Open AccessArticle

Food–Drug Interaction between the Adlay Bran Oil and Drugs in Rats

by Hsien-Tsung Yao, Jia-Hsuan Lin, Yun-Ta Liu, Mei-Ling Li and Wenchang Chiang

Nutrients 2019, 11(10), 2473; https://doi.org/10.3390/nu11102473 - 15 Oct 2019

Cited by 6 | Viewed by 3043

Abstract

Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) contains various phytonutrients for treating many diseases in Asia. To investigate whether orally administered adlay bran oil (ABO) can cause drug interactions, the effects of ABO on the pharmacokinetics of five cytochrome P450 (CYP) probe drugs were evaluated. Rats were given a single oral dose (2.5 mL/kg BW) of ABO 1 h before administration of a drug cocktail either orally or intravenously, and blood was collected at various time points. A single oral dose of ABO administration did not affect the pharmacokinetics of five probe drugs when given as a drug cocktail intravenously. However, ABO increased plasma theophylline (+28.4%), dextromethorphan (+48.7%), and diltiazem (+46.7%) when co-administered an oral drug cocktail. After 7 days of feeding with an ABO-containing diet, plasma concentrations of theophylline (+45.4%) and chlorzoxazone (+53.6%) were increased after the oral administration of the drug cocktail. The major CYP enzyme activities in the liver and intestinal tract were not affected by ABO treatment. Results from this study indicate that a single oral dose or short-term administration of ABO may increase plasma drug concentrations when ABO is given concomitantly with drugs. ABO is likely to enhance intestinal drug absorption. Therefore, caution is needed to avoid food–drug interactions between ABO and co-administered drugs. Full article

(This article belongs to the Special Issue Drug-Nutrition Interactions)

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