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Clinical Impact of Plant-Based Dietary Choices

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: closed (1 May 2023) | Viewed by 11496

Special Issue Editors


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Guest Editor
Department of Health Care, Design and Technology, Nutrition and Dietetics Program, Erasmushogeschool Brussel, 1090 Brussels, Belgium
Interests: nutrition; health; education; movement; plant-based
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Health Care, Design and Technology, Nutrition and Dietetics Program, Erasmushogeschool Brussel, 1090 Brussels, Belgium
Interests: nutrition; health; education; plant-based; sports
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The definition of what constitutes a healthy diet is constantly evolving; nevertheless, it is crucial to reflect on the role of various foods, essential nutrients, and other food components in health and disease. A large and growing body of evidence supports that the intake of certain types of nutrients, food groups specific to a plant-based diet positively affects health and promotes the prevention of common non-communicable diseases (NCDs). To better understand the clinical impact of plant-based dietary choices, it is important to map these outcomes. Evidence from previous epidemiological studies and clinical trials endorses that the risk of NCDs, including cardiovascular disease and cancer, is reduced due to a plant-based diet.

These previous studies already show that plant-based diets are generally in line with the WHO’s Global Action Plan for the Prevention and Control of Non-Communicable Diseases. Compared to the current Western omnivorous diet, plant-based diets contain more vegetables, fresh fruits, legumes, whole grains, seeds, and nuts and less to no animal foods. However, further efforts are needed to integrate and measure the impact of plant-based dietary and lifestyle choices in clinical settings as well as making healthy plant-based eating sustainable, accessible, and feasible for all.

This is why we look for articles that answer the following questions and themes:

- What are the clinical impacts and benefits of plant-based dietary choices on metabolic health and other non-communicable diseases?

- What are the clinical risks and benefits of plant-based dietary choices? How could possible risks be avoided? How can the potential benefits reach everyone and be optimally applied?

We welcome all articles that help to clarify the role of plant-based dietary choices and their impact on health in clinical settings.

Dr. Peter Deriemaeker
Dr. Evelien Mertens
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant-based
  • dietary choices
  • clinical impact
  • health benefits
  • health prevention

Published Papers (3 papers)

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Research

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11 pages, 692 KiB  
Article
Vegan Diet Is Associated with a Lower Risk of Chronic Kidney Disease in Patients with Hyperuricemia
by Chia-Lin Wu, Wen-Hsin Tsai, Jia-Sin Liu, Hao-Wen Liu, Sin-Yi Huang and Ko-Lin Kuo
Nutrients 2023, 15(6), 1444; https://doi.org/10.3390/nu15061444 - 16 Mar 2023
Cited by 8 | Viewed by 3159
Abstract
Hyperuricemia is a well-known risk factor for chronic kidney disease (CKD). Little is known about whether a vegetarian diet is associated with a lower risk of CKD in patients with hyperuricemia. From 5 September 2005, to 31 December 2016, we retrospectively included clinically [...] Read more.
Hyperuricemia is a well-known risk factor for chronic kidney disease (CKD). Little is known about whether a vegetarian diet is associated with a lower risk of CKD in patients with hyperuricemia. From 5 September 2005, to 31 December 2016, we retrospectively included clinically stable patients with hyperuricemia who received health check-ups at Taipei Tzu Chi Hospital. All participants completed a dietary habits questionnaire to determine whether they were omnivorous, lacto-ovo vegetarian, or vegan. CKD was defined as an estimated glomerular filtration rate <60 mL/min/1.73 m2 or the presence of proteinuria. A total of 3618 patients with hyperuricemia were recruited for this cross-sectional study, consisting of 225 vegans, 509 lacto-ovo vegetarians, and 2884 omnivores. After adjusting for age and sex, vegans had a significantly lower odds ratio (OR) of CKD than omnivores (OR, 0.62; p = 0.006). The OR of CKD remained significantly lower in vegans after adjusting for additional confounders (OR, 0.69; p = 0.04). Additionally, age (per year OR, 1.06; p < 0.001), diabetes mellitus (OR, 2.12; p < 0.001), hypertension (OR, 1.73; p < 0.001), obesity (OR, 1.24; p = 0.02), smoking (OR, 2.05; p < 0.001), and very high uric acid levels (OR, 2.08; p < 0.001) were independent risk factors for CKD in patients with hyperuricemia. Moreover, structural equation modeling revealed that a vegan diet was associated with a lower OR of CKD (OR, 0.69; p < 0.05). A vegan diet is associated with a 31% lower risk of CKD in patients with hyperuricemia. A vegan diet may be beneficial in reducing the occurrence of CKD in patients with hyperuricemia. Full article
(This article belongs to the Special Issue Clinical Impact of Plant-Based Dietary Choices)
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12 pages, 1804 KiB  
Article
The Degree of Hydroxylation of Phenolic Rings Determines the Ability of Flavonoids and Stilbenes to Inhibit Calcium-Mediated Membrane Fusion
by Polina D. Zlodeeva, Egor V. Shekunov, Olga S. Ostroumova and Svetlana S. Efimova
Nutrients 2023, 15(5), 1121; https://doi.org/10.3390/nu15051121 - 23 Feb 2023
Cited by 2 | Viewed by 1648
Abstract
This paper discusses the possibility of using plant polyphenols as viral fusion inhibitors with a lipid-mediated mechanism of action. The studied agents are promising candidates for the role of antiviral compounds due to their high lipophilicity, low toxicity, bioavailability, and relative cheapness. Fluorimetry [...] Read more.
This paper discusses the possibility of using plant polyphenols as viral fusion inhibitors with a lipid-mediated mechanism of action. The studied agents are promising candidates for the role of antiviral compounds due to their high lipophilicity, low toxicity, bioavailability, and relative cheapness. Fluorimetry of calcein release at the calcium-mediated fusion of liposomes, composed of a ternary mixture of dioleoyl phosphatidylcholine, dioleoyl phosphatidylglycerol, and cholesterol, in the presence of 4′-hydroxychalcone, cardamonin, isoliquiritigenin, phloretin, resveratrol, piceatannol, daidzein, biochanin A, genistein, genistin, liquiritigenin, naringenin, catechin, taxifolin, and honokiol, was performed. It was found that piceatannol significantly inhibited the calcium-induced fusion of negatively charged vesicles, while taxifolin and catechin showed medium and low antifusogenic activity, respectively. As a rule, polyphenols containing at least two OH-groups in both phenolic rings were able to inhibit the calcium-mediated fusion of liposomes. In addition, there was a correlation between the ability of the tested compounds to inhibit vesicle fusions and to perturb lipid packing. We suggest that the antifusogenic action of polyphenols was determined by the depth of immersion and the orientation of the molecules in the membrane. Full article
(This article belongs to the Special Issue Clinical Impact of Plant-Based Dietary Choices)
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Review

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23 pages, 452 KiB  
Review
Nutritional Assessment of the Symptomatic Patient on a Plant-Based Diet: Seven Key Questions
by Gregory A. Plotnikoff, Linda Dobberstein and Susan Raatz
Nutrients 2023, 15(6), 1387; https://doi.org/10.3390/nu15061387 - 13 Mar 2023
Cited by 4 | Viewed by 6228
Abstract
Plant-based diets, both vegan and vegetarian, which emphasize grains, vegetables, fruits, legumes, nuts, and seeds are increasingly popular for health as well as financial, ethical, and religious reasons. The medical literature clearly demonstrates that whole food plant-based diets can be both nutritionally sufficient [...] Read more.
Plant-based diets, both vegan and vegetarian, which emphasize grains, vegetables, fruits, legumes, nuts, and seeds are increasingly popular for health as well as financial, ethical, and religious reasons. The medical literature clearly demonstrates that whole food plant-based diets can be both nutritionally sufficient and medically beneficial. However, any person on an intentionally restrictive, but poorly-designed diet may predispose themselves to clinically-relevant nutritional deficiencies. For persons on a poorly-designed plant-based diet, deficiencies are possible in both macronutrients (protein, essential fatty acids) and micronutrients (vitamin B12, iron, calcium, zinc, and vitamin D). Practitioner evaluation of symptomatic patients on a plant-based diet requires special consideration of seven key nutrient concerns for plant-based diets. This article translates these concerns into seven practical questions that all practitioners can introduce into their patient assessments and clinical reasoning. Ideally, persons on plant-based diets should be able to answer these seven questions. Each serves as a heuristic prompt for both clinician and patient attentiveness to a complete diet. As such, these seven questions support increased patient nutrition knowledge and practitioner capacity to counsel, refer, and appropriately focus clinical resources. Full article
(This article belongs to the Special Issue Clinical Impact of Plant-Based Dietary Choices)
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