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Special Issue Editors

Prof. Dr. Juan M. Ruso

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Guest Editor

Soft Matter and Molecular Biophysics Group, Department of Applied Physics, University of Santiago de Compostela, E-15782 Santiago de Compostela, Spain
Interests: synthesis and characterization of nanostructured templated materials; biophysics of proteins and protein interactions; self-aggregation processes
Special Issues, Collections and Topics in MDPI journals

Dr. Ramón Rial

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Assistant Guest Editor

Soft Matter and Molecular Biophysics Group, Department of Applied Physics,University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
Interests: hydrogel; molecular biophysics; tissue engineering; 3D printing; nanoparticles; nanofibers

Special Issue Information

Dear Colleagues,

The social and industrial demand for new materials with specific and efficient properties has turned this area into a fundamental axis of human development. There are innumerable routes, syntheses, and procedures to obtain these materials. However, the template method is possibly the most widely used. In this procedure, the template or scaffolding plays a decisive role in determining the morphology, architecture, and fundamental characteristics of the material to be developed. A special type of scaffolding is the so-called “soft scaffolding”. Within this class, hydrogels have experienced a great interest, especially in the design of materials for biomedical applications such as tissue engineering, bone regeneration, drug delivery, cellular support, biological sensing or theragnostics. The aim of this special issue is to provide a broad and critical overview of the current state-of-the-art in this field, focusing on both the most novel synthetic routes and the most daring applications.

Prof. Dr. Juan M. Ruso
Guest Editor

Dr. Ramón Rial
Assistant Guest Editor

Manuscript Submission Information

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Keywords

nanomaterials
hydrogels
tissue engineering
biomaterials
nanoscience

Published Papers (2 papers)

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Research

16 pages, 4257 KiB

Open AccessArticle

The Effects of Chitosan on the Healing Process of Oral Mucosa: An Observational Cohort Feasibility Split-Mouth Study

by Gonçalo de Jesus, Lara Marques, Nuno Vale and Rui Amaral Mendes

Nanomaterials 2023, 13(4), 706; https://doi.org/10.3390/nano13040706 - 12 Feb 2023

Cited by 5 | Viewed by 3366

Abstract

The healing process is a dynamic process accompanied by some classical symptoms of inflammation such as redness, swelling, pain, and loss of function. Chitosan is a natural polymer with properties that contribute to tissue healing, with properties that could be applied in periodontal therapy, such as the wound healing of oral mucosa. This experimental split-mouth study aims to assess the possibilities of chitosan influencing the healing process of oral mucosa in eight patients, where the studied group was subjected to two oral surgeries: one with chitosan hydrogel into the socket and other without the biomaterial. A semi-quantitative analysis of the data was performed. Some classic signs of inflammation in a short period of time were observed where chitosan acted, compared to the control. An absence of bleeding was observed in the chitosan cases. According to the literature, chitosan recruits and activates neutrophils and macrophages and stimulates angiogenesis. Hemostatic and antimicrobial activity of chitosan also play an important role in wound healing. Chitosan seems to improve the postoperative quality of patients, allowing rapid wound healing with less complications. Full article

(This article belongs to the Special Issue Properties and Structure of Templated and Hydrogel-Related Nanomaterials)

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19 pages, 4137 KiB

Open AccessFeature PaperArticle

Microfluidic Fabrication of Gadolinium-Doped Hydroxyapatite for Theragnostic Applications

by Manuel Somoza, Ramón Rial, Zhen Liu, Iago F. Llovo, Rui L. Reis, Jesús Mosqueira and Juan M. Ruso

Nanomaterials 2023, 13(3), 501; https://doi.org/10.3390/nano13030501 - 26 Jan 2023

Cited by 6 | Viewed by 1737

Abstract

Among the several possible uses of nanoparticulated systems in biomedicine, their potential as theragnostic agents has received significant interest in recent times. In this work, we have taken advantage of the medical applications of Gadolinium as a contrast agent with the versatility and huge array of possibilities that microfluidics can help to create doped Hydroxyapatite nanoparticles with magnetic properties in an efficient and functional way. First, with the help of Computational Fluid Dynamics (CFD), we performed a complete and precise study of all the elements and phases of our device to guarantee that our microfluidic system worked in the laminar regime and was not affected by the presence of nanoparticles through the flow requisite that is essential to guarantee homogeneous diffusion between the elements or phases in play. Then the obtained biomaterials were physiochemically characterized by means of XRD, FE-SEM, EDX, confocal Raman microscopy, and FT-IR, confirming the successful incorporation of the lanthanide element Gadolinium in part of the Ca (II) binding sites. Finally, the magnetic characterization confirmed the paramagnetic behaviour of the nanoparticles, demonstrating that, with a simple and automatized system, it is possible to obtain advanced nanomaterials that can offer a promising and innovative solution in theragnostic applications. Full article

(This article belongs to the Special Issue Properties and Structure of Templated and Hydrogel-Related Nanomaterials)

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