Special Issue "Disulfide and Diselenide Chemistry"


A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (31 December 2012)

Special Issue Editor

Guest Editor
Dr. Stevenson Flemer
Department of Chemistry, University of Vermont, Burlington, VT 05405, USA
Website: http://biochem.uvm.edu/flemer-lab/
E-Mail: sflemer@uvm.edu
Interests: peptide synthetic methodology; disulfide and diselenide chemistry

Special Issue Information

Dear Colleagues,

Unique among the elements' chemical properties are the abilities of some of the chalcogens to dimerize covalently, forming linkages which are oxidatively reversible. Disulfide and (to a lesser extent) diselenide bond-forming reactions constitute an important vector of covalent bond construction in organic synthesis, in part due to their well-established reversibility which allows for enhanced molecular engineering potential. Their construction being oxidatively induced primarily through manipulation of reduced thiol and selenol precursors, disulfide and diselenide bond formation expand the repertoire of available strategies for organic chemists toward synthetic design. Although the prevalence of chemical syntheses toward the manufacture of these structural motifs are frequently confined to post-synthetic manipulation of peptide systems, small molecule drug design is increasingly dependent upon the inclusion of disulfide and diselenide-bonded intermediates. Moreover, biological vectors are increasingly recruited in which disulfide and diselenide bridges are artificially inserted or interchanged in native protein structures in order to tune their activity or elucidate the mechanism of action.

This special issue of Molecules encourages the submission of previously unpublished research describing investigative efforts in the area of disulfide and diselenide bond formation, mode-of-action, and physiochemical properties. In addition to synthetic methodology toward the manufacture of disulfide and diselenide architecture, reports pertaining to direct practical application of these structural systems are encouraged.

Dr. Stevenson Flemer 
Guest Editor


  • disulfide
  • diselenide
  • selenylsulfide
  • cysteine
  • selenocysteine
  • thiol
  • selenol

Published Papers (3 papers)

by , , , ,  and
Molecules 2013, 18(5), 5155-5162; doi:10.3390/molecules18055155
Received: 16 February 2013; in revised form: 26 April 2013 / Accepted: 2 May 2013 / Published: 6 May 2013
Show/Hide Abstract | Cited by 3 | PDF Full-text (677 KB)
abstract graphic

by ,  and
Molecules 2013, 18(2), 1963-1972; doi:10.3390/molecules18021963
Received: 9 January 2013; in revised form: 28 January 2013 / Accepted: 30 January 2013 / Published: 4 February 2013
Show/Hide Abstract | PDF Full-text (232 KB) | Supplementary Files
abstract graphic

by , , ,  and
Molecules 2012, 17(11), 13307-13329; doi:10.3390/molecules171113307
Received: 28 September 2012; in revised form: 31 October 2012 / Accepted: 5 November 2012 / Published: 8 November 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (598 KB) | Supplementary Files
abstract graphic

Last update: 4 March 2014

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