Special Issue "Glycomics and Glycoproteomics"
A special issue of Metabolites (ISSN 2218-1989).
Deadline for manuscript submissions: closed (20 September 2012)
Dr. Yehia Mechref
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409-1061, USA
Interests: Analytical and Bioanalytical methods, Chemical Separation, Glycomics, Glycoproeomics, Proteomics
The importance of posttranslational modifications in modulating the activities and functions of proteins in health and disease is illustrated by the fact that no more than 30,000-50,000 proteins are encoded by the human genome. The importance of protein glycosylation has been reflected in the fact that cell-cell interactions involve sugar-sugar, or sugar-protein specific recognition. Consequently, aberrant glycosylation has now been recognized as the attribute of many mammalian diseases, including hereditary disorders, immune deficiencies, neurodegenerative diseases, cardiovascular disease, and cancer. This special issue will focus on detailing the emerging trends in glycomics and glycoproteomics allowing better understanding of the biological roles of glycans and glycoproteins.
This special issue will consider research papers focused on the analysis and characterization of glycans and glycoproteins to allow better understanding of their biological roles. Novel liquid phase separation methods (HPLC, Nano-LC, gel electrophoresis, CE, CEC, microchip, and microfluidics) combined with all kinds of detection including on line and off line mass spectrometry and laser-induced fluorescence detection or any other type of detection are of high interest for this issue. Papers describing novel sample derivatization, preparation/concentration ,or any enrichment approaches will be considered for publication in this issue.
Dr. Yehia Mechref
- capillary electrophoresis
- lectin affinity chromatography
- glycoprotein enrichment
- computational approaches
- data interpretation
Metabolites 2012, 2(4), 1060-1089; doi:10.3390/metabo2041060
Received: 10 October 2012; in revised form: 13 November 2012 / Accepted: 15 November 2012 / Published: 28 November 2012| PDF Full-text (356 KB) | HTML Full-text | XML Full-text
Metabolites 2012, 2(4), 1004-1011; doi:10.3390/metabo2041004
Received: 25 September 2012; in revised form: 5 November 2012 / Accepted: 9 November 2012 / Published: 21 November 2012| PDF Full-text (177 KB) | HTML Full-text | XML Full-text
Article: Comparative Analysis of End Point Enzymatic Digests of Arabino-Xylan Isolated from Switchgrass (Panicum virgatum L) of Varying Maturities using LC-MSn
Metabolites 2012, 2(4), 959-982; doi:10.3390/metabo2040959
Received: 14 September 2012; in revised form: 30 October 2012 / Accepted: 9 November 2012 / Published: 19 November 2012| Cited by 1 | PDF Full-text (683 KB) | HTML Full-text | XML Full-text | Supplementary Files
Review: Tumor-Associated Glycans and Their Role in Gynecological Cancers: Accelerating Translational Research by Novel High-Throughput Approaches
Metabolites 2012, 2(4), 913-939; doi:10.3390/metabo2040913
Received: 31 October 2012; in revised form: 8 November 2012 / Accepted: 9 November 2012 / Published: 14 November 2012| Cited by 2 | PDF Full-text (373 KB) | HTML Full-text | XML Full-text
Article: Structural Identification of O-Linked Oligosaccharides Using Exoglycosidases and MSn Together with UniCarb-DB Fragment Spectra Comparison
Metabolites 2012, 2(4), 648-666; doi:10.3390/metabo2040648
Received: 17 July 2012; in revised form: 18 September 2012 / Accepted: 28 September 2012 / Published: 8 October 2012| Cited by 2 | PDF Full-text (796 KB) | HTML Full-text | XML Full-text
Last update: 27 February 2014