Bioactive Lipids in Neuroinflammatory Diseases
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".
Deadline for manuscript submissions: 10 January 2025 | Viewed by 697
Special Issue Editors
Interests: inflammation; resolution of inflammation; bioactive lipids
2. Department of Clinical Neuroscience, The University of Cambridge, Cambridge, UK
Interests: alpha-synuclein; neurodegeneration; neuroanatomy; Parkinson’s disease; molecular biomarkers
Special Issue Information
Dear Colleagues,
Endogenous bioactive lipids such as arachidonic acid-derived autacoids (i.e., prostaglandins, leukotrienes, and thromboxanes), sphingolipids, specialized pro-resolving mediators (SPM), endocannabinoids, and fatty acyl esters of hydroxy fatty acids (FAHFA) are the effectors of a convoluted signaling network that controls initiation, coordination, and resolution of the inflammatory event; as a matter of fact, these molecules act on all cellular and molecular events of host defense, control phenotype, differentiation, and recruiting and trafficking of all immune cells, as well as their ability to influence tissue homeostasis through soluble mediators such as cytokines and chemokines. More importantly, the disruption of these lipid molecular networks, or their dysfunctional activity, is a primary event in the aberrant immune response that leads to neuroinflammatory damage of many—if not all—neurodegenerative diseases. This issue focuses on gathering the most recent molecular evidence on the involvement of endogenous bioactive lipids in neurodegenerative conditions, their role in kickstarting or preventing tissue damage, and their perspective either as possible therapeutic targets or diagnostic tools.
Dr. Alessandro Leuti
Dr. Giorgio Vivacqua
Guest Editors
Manuscript Submission Information
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