Metabolomics in Metabolic Engineering Volume 2

Dear Colleagues,

The past decade has seen an explosion in genomic information to guide molecular breeding approaches for the introduction of biotechnologically useful traits into plants for next-generation (nonfood) bioenergy crops and specialized, economically attractive metablite biosynthesis. Genome resources have stimulated groundbreaking studies that address a variety of technical barriers to help alleviate unintended nutritional, abiotic and biotic stresses often observed for transgenic plants, which must be overcome to enable expanded use. These breakthroughs have benefited from multidisciplinary approaches involving computational, experimental and technical developments, especially in the areas of genomics and systems biology, and include transcriptomics and metabolomics, as well as modeling efforts to integrate global data at the cellular level. Importantly, the outstanding advances in genomics, systems and synthetic biology elucidate the important metabolic responses of plants to nutritional, abiotic and biotic stresses, as well as the metabolic cross-talk among these physiological systems. Consequently, these developments, coupled with innovative tools for biodesign, are increasing our ability to more rapidly engineer plants in ways that enhance our understanding of how interconnected cellular networks can contribute to and affect metabolism and cellular control, and they have a broad range of applications in pharmaceutical development, the nutritional enhancement of plants to improve human health, biomanufacturing and biofuel production. Accordingly, this Special Issue of Metabolites will focus on multidisciplinary aspects of the design and engineering of diverse plants as feedstocks for biofuel and specialty compound biosynthesis, especially concerning how they respond to limited nutrients, abiotic stresses and defense against pathogens, and will highlight computational, experimental and technical approaches for metabolic engineering.

Dr. Edward Eisenstein
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• metabolomics
• metabolic engineering
• systems biology
• synthetic biology
• biodesign
• abiotic stress
• nutrient management
• biotic stress
• plant disease resistance
• specialized metabolites
• natural products
• biomanufacturing
• nutrition
• biofuel