Metabolic Correction and Optimization for Improving Outcomes in Chronic Diseases

Dear Colleagues,

Metabolic correction has been proposed as a physiological concept that guides intervention. It is based on detailed assessment to determine particular patient needs in order to improve health, energy, cognition and performance. Metabolic correction is directed to provide the necessary precursors and enzymatic cofactors needed to increase specific metabolites that are likely insufficient and to improve metabolic pathways. These insufficiencies have been associated with cellular dysfunction that leads to physiologic impairment. All chronic conditions have been associated with biochemical abnormalities which commonly remain unidentified and untreated because they are not described in the current therapeutic approaches. Moreover, they are not part of the medical guidelines and are not covered by medical insurance. Metabolic correction addresses biochemical disturbances and assists the body in achieving balance, harmony and a healthy homeostasis. When underlying causes are properly addressed, the innate healing mechanisms will respond, and health will be restored. Some of the underlying causes to be considered include nutritional, genetotrophic, bioenergetic, toxicologic, psychological, microbiomic and others.

This Special Issue is dedicated to metabolic optimization in the management of chronic diseases. We will discuss the mechanisms, benefits and clinical evidence on the application of metabolic correction to address chronic diseases such as hypertension, stroke, artery disease, neuropathy, cognitive decline and dementia, autism, psychiatric disorders cancer, regenerative innovations, oxidative therapies and autoimmune disorders.

Dr. Jorge R. Miranda-Massari
Prof. Dr. Michael J Gonzalez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• metabolic correction
• metabolic optimization
• diet
• precursors
• cofactors
• enzymes
• vitamins
• mineral
• micronutrients
• metabolites
• epigenetics
• nutrigenomics
• microbiome