Mitochondrial Metabolism in Cell Homeostasis and Disease

Dear Colleagues,

Since their likely endosymbiotic origin, mitochondria have been a major feature of eukaryotic cells. The major mitochondrial functions include ATP production, mediated by the mitochondrial oxidative phosphorylation system, the triggering of apoptosis encompassing the mitochondrial outer membrane permeabilization, and the regulation of calcium homeostasis through interactions with the endoplasmic reticulum. Mitochondria are implicated also in the production of reactive oxygen species (ROS) and in ROS detoxification, being particularly susceptible to oxidative stress and major players in redox homeostasis. Mitochondria have their own genome and are highly dynamic organelles, undergoing fusion and fission, being involved in the regulation of innumerous cellular activities, including cell-cycle regulation, cell differentiation, cell proliferation, mitophagy, and autophagy. Due to the critical role of mitochondria in cell homeostasis and metabolism, mitochondrial dysfunctions can have a severe impact on the host, being involved in disorders including cancer, metabolic, cardiac, and neurodegenerative diseases.

In this Special Issue, we aim at collecting a sample of the latest research in mitochondrial metabolism. Altogether, the published articles will reinforce the significance of this organelle in the functioning of the cell and in human diseases. We welcome original research and review manuscripts on any aspects of mitochondrial metabolism, including mitochondrial dynamics, mitochondrial genetics, bioenergetics, the intrinsic pathway of apoptosis, regulation of calcium levels, and oxidative stress. Studies on mitochondrial dysfunction in human disorders including cancer, metabolic, cardiac, and neurodegenerative diseases, are also welcome. As the mitochondrion is a common link among these fields, participating researchers may uncover broader implications of their findings.

With our best regards,

Dr. Joao Pessoa
Dr. Susana P. Pereira
Dr. Ana Isabel Duarte
Guest Editors

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• mitochondrion
• bioenergetics
• oxidative stress
• calcium homeostasis
• apoptosis
• cancer
• metabolic diseases
• cardiovascular diseases
• neurodegenerative diseases