Thyroid Cytopathology

Dear Colleagues,

Thyroid nodules are now a very common clinical problem, frequently assessed by fine-needle aspiration biopsy and cytologic evaluation. Recent changes in the field have created new questions and clinical uncertainties that demand further research investigations.

Thyroid cytopathology has long been regarded as the best method for stratifying the risk of malignancy pre-operatively. Numerous studies have documented the accuracy of benign and malignant cytology, while indeterminate cytologic findings have continued to represent a clinical challenge. Introduced almost 10 years ago, the Bethesda System for Reporting Thyroid Cytopathology is now widely recommended, but its ideal use is still being defined. Research indicates that different cytopathologic categories may predict not only malignant, but cancer histology, and disease aggressively.

Current methods for molecular testing and refined sonographic evaluation have introduced additional methods for assessing thyroid cancer risk, which need to be incorporated into our interpretation of cytopathologic findings. In addition, reclassification of some thyroid “cancer” as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) alters our diagnostic models and challenges our previous paradigms. Understanding the implications and impacts of these changes is vital to improving effective outcomes for our patients.

This Special Issue will address important topics and current controversies in thyroid cytopathology. Examples could include manuscripts discussing novel cytopathologic findings in thyroid disease, comparing methods of biopsy, or exploring integrated cytopathology, genomic and sonographic assessment of thyroid malignancy. Short and focused reviews will be considered for publication.

We hope that this Special Issue will provide an update on advances and challenges in the field of thyroid cytopathology and clinical endocrinology to improve clinical care, ignite new directions for further investigation, and provide quick references on the cutting edge of thyroid cytopathology for practitioners.

We look forward to receiving your contributions.

Dr. Trevor Edmund Angell
Guest Editor

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• cytology
• immunohistochemistry
• genomic molecular testing
• papillary thyroid cancer
• thyroid nodule
• histology
• NIFTP
• ultrasound and cytology