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  • Feature Paper
  • Review
  • Open Access
1,325 Citations
43,093 Views
16 Pages

Flavonoids and Other Phenolic Compounds from Medicinal Plants for Pharmaceutical and Medical Aspects: An Overview

  • Duangjai Tungmunnithum,
  • Areeya Thongboonyou,
  • Apinan Pholboon and
  • Aujana Yangsabai

Phenolic compounds as well as flavonoids are well-known as antioxidant and many other important bioactive agents that have long been interested due to their benefits for human health, curing and preventing many diseases. This review attempts to demon...

(This article belongs to the Special Issue Antioxidant and Anti-Aging Action of Plant Polyphenols)
  • Review
  • Open Access
1,098 Citations
51,700 Views
21 Pages

Extensive documentation on the antimicrobial properties of essential oils and their constituents has been carried out by several workers. Although the mechanism of action of a few essential oil components has been elucidated in many pioneering works...

(This article belongs to the Special Issue Antimicrobial, Antioxidant and Anti-Inflammatory Activities of Essential Oils)
  • Review
  • Open Access
885 Citations
50,171 Views
16 Pages

22 September 2016

This review covers literature data summarizing, on one hand, the chemistry of essential oils and, on the other hand, their most important activities. Essential oils, which are complex mixtures of volatile compounds particularly abundant in aromatic p...

(This article belongs to the Special Issue Essential Oils: Chemistry and Bioactivity)
  • Review
  • Open Access
587 Citations
44,796 Views
36 Pages

8 September 2015

Plants produce a wide diversity of secondary metabolites (SM) which serve them as defense compounds against herbivores, and other plants and microbes, but also as signal compounds. In general, SM exhibit a wide array of biological and pharmacological...

(This article belongs to the Special Issue Herbal Medicines and Natural Products)
  • Review
  • Open Access
410 Citations
52,670 Views
13 Pages

4 September 2018

Nowadays, there is an interest in the consumption of food without synthetic additives and rather with the use of natural preservatives. In this regard, natural extracts of the Lamiaceae family, such as rosemary, have been studied because of its bioac...

(This article belongs to the Special Issue Medicinal Plants and Foods)
  • Review
  • Open Access
191 Citations
64,123 Views
15 Pages

A Short Review of Iron Metabolism and Pathophysiology of Iron Disorders

  • Andronicos Yiannikourides and
  • Gladys O. Latunde-Dada

Iron is a vital trace element for humans, as it plays a crucial role in oxygen transport, oxidative metabolism, cellular proliferation, and many catalytic reactions. To be beneficial, the amount of iron in the human body needs to be maintained within...

(This article belongs to the Section Endocrinology and Metabolic Disorders)
  • Editorial
  • Open Access
185 Citations
27,899 Views
9 Pages

The present editorial serves as an introduction to the Special Issue “Antioxidant and Anti-aging Action of Plant Polyphenols”. It also provides a summary of the polyphenols, their biological properties and possible functions as medicines,...

(This article belongs to the Special Issue Antioxidant and Anti-Aging Action of Plant Polyphenols)
  • Review
  • Open Access
180 Citations
17,401 Views
10 Pages

Herbs and spices have been used since ancient times to improve the sensory characteristics of food, to act as preservatives and for their nutritional and healthy properties. Herbs and spices are generally recognized as safe (GRAS) and are excellent s...

(This article belongs to the Special Issue Antimicrobial, Antioxidant and Anti-Inflammatory Activities of Essential Oils)
  • Review
  • Open Access
178 Citations
19,795 Views
24 Pages

9 September 2019

Background: Weight management and obesity prevention is a basic aim of health organizations in order to decrease the prevalence of various metabolic disorders. The aim of the present review article was the evaluation of the possible role of functiona...

  • Article
  • Open Access
157 Citations
18,754 Views
17 Pages

Background: Propolis consists of a complex mixture of resinous substances collected by honeybees from different plant sources. The objective of this study was to investigate the chemical composition, biological activities, and synergistic properties...

(This article belongs to the Special Issue Bioactivities and Medical Use of Herbs and Plants)
  • Review
  • Open Access
142 Citations
30,167 Views
47 Pages

Cannabis and Its Secondary Metabolites: Their Use as Therapeutic Drugs, Toxicological Aspects, and Analytical Determination

  • Joana Gonçalves,
  • Tiago Rosado,
  • Sofia Soares,
  • Ana Y. Simão and ,
  • Débora Caramelo,
  • Ângelo Luís,
  • Nicolás Fernández,
  • Mário Barroso,
  • Eugenia Gallardo and
  • Ana Paula Duarte
  • + 5 authors+ 0 author

23 February 2019

Although the medicinal properties of Cannabis species have been known for centuries, the interest on its main active secondary metabolites as therapeutic alternatives for several pathologies has grown in recent years. This potential use has been a re...

(This article belongs to the Special Issue Biological Potential and Medical Use of Secondary Metabolites)
  • Article
  • Open Access
142 Citations
12,457 Views
9 Pages

The non-polar components of two leguminoceae species Albizia adianthifolia (Schumach), and Pterocarpus angolensis (DC) were investigated. GC-MS analysis of the crude n-hexane and chloroform extracts together with several chromatographic separation te...

(This article belongs to the Special Issue Essential Oils: Chemistry and Bioactivity)
  • Review
  • Open Access
141 Citations
51,814 Views
12 Pages

Music Therapy and Other Music-Based Interventions in Pediatric Health Care: An Overview

  • Thomas Stegemann,
  • Monika Geretsegger,
  • Eva Phan Quoc,
  • Hannah Riedl and
  • Monika Smetana

14 February 2019

Background: In pediatric health care, non-pharmacological interventions such as music therapy have promising potential to complement traditional medical treatment options in order to facilitate recovery and well-being. Music therapy and other music-b...

(This article belongs to the Special Issue Music Therapy)
  • Review
  • Open Access
137 Citations
16,202 Views
74 Pages

Ovarian Cancers: Genetic Abnormalities, Tumor Heterogeneity and Progression, Clonal Evolution and Cancer Stem Cells

  • Ugo Testa,
  • Eleonora Petrucci,
  • Luca Pasquini,
  • Germana Castelli and
  • Elvira Pelosi

1 February 2018

Four main histological subtypes of ovarian cancer exist: serous (the most frequent), endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large majority of ovarian cancers are diagnosed as high-grade serous ovarian cancers...

(This article belongs to the Section Cancer Biology and Anticancer Therapeutics)
  • Review
  • Open Access
124 Citations
21,774 Views
12 Pages

23 January 2018

Hydroxytyrosol (HXT) is a phenolic compound drawn from the olive tree and its leaves as a by-product obtained from the manufacturing of olive oil. It is considered the most powerful antioxidant compound after gallic acid and one of the most powerful...

(This article belongs to the Special Issue Medicinal Plants and Foods)
  • Review
  • Open Access
120 Citations
23,096 Views
25 Pages

Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol

  • Muhammad Shahdaat Bin Sayeed,
  • Selim Muhammad Rezaul Karim,
  • Tasnuva Sharmin and
  • Mohammed Monzur Morshed

15 November 2016

Beta-sitosterol (BS) is a phytosterol, widely distributed throughout the plant kingdom and known to be involved in the stabilization of cell membranes. To compile the sources, physical and chemical properties, spectral and chromatographic analytical...

(This article belongs to the Special Issue Herbal Medicines and Functional Foods)
  • Review
  • Open Access
118 Citations
71,846 Views
19 Pages

15 October 2020

Background: Breathing is an essential part of life. Diaphragmatic breathing (DB) is slow and deep breathing that affects the brain and the cardiovascular, respiratory, and gastrointestinal systems through the modulation of autonomic nervous functions...

(This article belongs to the Special Issue Research Topics in Medicines and How Our Board Members Are Engaged in Them)
  • Review
  • Open Access
113 Citations
24,296 Views
10 Pages

18 January 2019

Traditional Chinese medicine (TCM) is not only used prevalently in Asian countries but has also gained a stable market globally. As a principal form of TCM, Chinese herbal medicine (CHM) is comprised of treatments using multiple Chinese herbs which h...

(This article belongs to the Special Issue Safety of Complementary Medicines)
  • Review
  • Open Access
108 Citations
20,811 Views
15 Pages

12 September 2017

Essential oils of aromatic and medicinal plants generally have a diverse range of activities because they possess several active constituents that work through several modes of action. The genus Artemisia includes the largest genus of family Asterace...

(This article belongs to the Special Issue Antimicrobial, Antioxidant and Anti-Inflammatory Activities of Essential Oils)
  • Review
  • Open Access
108 Citations
19,152 Views
136 Pages

Prostate cancer is the most frequent nonskin cancer and second most common cause of cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with many patients exhibiting an aggressive disease with progression, metastasis,...

(This article belongs to the Section Cancer Biology and Anticancer Therapeutics)
  • Review
  • Open Access
101 Citations
13,648 Views
10 Pages

Green Nanotechnology: Advancement in Phytoformulation Research

  • Ajay Verma,
  • Surya P. Gautam,
  • Kuldeep K. Bansal,
  • Neeraj Prabhakar and
  • Jessica M. Rosenholm

The ultimate goal of any scientific development is to increase well-being and human health. Novel strategies are required for the achievement of safe and effective therapeutic treatments beyond the conventional ones, and society needs new requirement...

(This article belongs to the Special Issue Nanoparticle and Liposome Based Novel Drug Delivery Systems)
  • Article
  • Open Access
99 Citations
13,056 Views
10 Pages

Total Polyphenol Content and Antioxidant Capacity of Rosehips of Some Rosa Species

  • Noémi Koczka,
  • Éva Stefanovits-Bányai and
  • Attila Ombódi

Background: Rosehips, the fruits of Rosa species, are well known for their various health benefits like strengthening the immune system and treating digestive disorders. Antioxidant, anti-inflammatory, and cell regenerative effects are also among the...

(This article belongs to the Special Issue Antioxidant and Anti-Aging Action of Plant Polyphenols)
  • Opinion
  • Open Access
94 Citations
29,157 Views
6 Pages

31 October 2017

The biopsychosocial model is a modern humanistic and holistic view of the human being in health sciences. Currently, many researchers think the biopsychosocial model should be expanded to include the spiritual dimension as well. However, “spiritual”...

(This article belongs to the Special Issue Mind-Body Medicine Approaches)
  • Review
  • Open Access
94 Citations
32,919 Views
55 Pages

19 February 2016

Aromatic plants have played key roles in the lives of tribal peoples living in the Himalaya by providing products for both food and medicine. This review presents a summary of aromatic medicinal plants from the Indian Himalaya, Nepal, and Bhutan, foc...

(This article belongs to the Special Issue Essential Oils: Chemistry and Bioactivity)
  • Review
  • Open Access
93 Citations
28,203 Views
28 Pages

Trying to Solve the Puzzle of the Interaction of Ascorbic Acid and Iron: Redox, Chelation and Therapeutic Implications

  • George J. Kontoghiorghes,
  • Annita Kolnagou,
  • Christina N. Kontoghiorghe,
  • Loukia Mourouzidis and ,
  • Viktor A. Timoshnikov and
  • Nikolay E. Polyakov
  • + 1 author+ 0 author

Iron and ascorbic acid (vitamin C) are essential nutrients for the normal growth and development of humans, and their deficiency can result in serious diseases. Their interaction is of nutritional, physiological, pharmacological and toxicological int...

(This article belongs to the Special Issue Biological Efficacy of Natural Products against Noncommunicable Diseases)
  • Review
  • Open Access
92 Citations
59,426 Views
12 Pages

Medicinal Cannabis—Potential Drug Interactions

  • Muhammad A. Alsherbiny and
  • Chun Guang Li

23 December 2018

The endocannabinoids system (ECS) has garnered considerable interest as a potential therapeutic target in various carcinomas and cancer-related conditions alongside neurodegenerative diseases. Cannabinoids are implemented in several physiological pro...

(This article belongs to the Special Issue Safety of Complementary Medicines)
  • Feature Paper
  • Article
  • Open Access
90 Citations
9,469 Views
9 Pages

Background: Natural antioxidants, which can replace synthetic ones due to their potential implications for health problems in children, have gained significant popularity. Therefore, the antioxidant potential of extracts obtained from three brown mac...

(This article belongs to the Special Issue Medicinal Plants and Foods)
  • Review
  • Open Access
89 Citations
15,313 Views
12 Pages

Aromatic Medicinal Plants of the Lamiaceae Family from Uzbekistan: Ethnopharmacology, Essential Oils Composition, and Biological Activities

  • Nilufar Z. Mamadalieva,
  • Davlat Kh. Akramov,
  • Elisa Ovidi,
  • Antonio Tiezzi and ,
  • Lutfun Nahar,
  • Shahnoz S. Azimova and
  • Satyajit D. Sarker
  • + 2 authors+ 0 author

10 February 2017

Plants of the Lamiaceae family are important ornamental, medicinal, and aromatic plants, many of which produce essential oils that are used in traditional and modern medicine, and in the food, cosmetics, and pharmaceutical industry. Various species o...

(This article belongs to the Special Issue Antimicrobial, Antioxidant and Anti-Inflammatory Activities of Essential Oils)
  • Review
  • Open Access
87 Citations
13,938 Views
19 Pages

The Epidemiology, Risk Profiling and Diagnostic Challenges of Nonalcoholic Fatty Liver Disease

  • Umair Iqbal,
  • Brandon J. Perumpail,
  • Daud Akhtar,
  • Donghee Kim and
  • Aijaz Ahmed

Nonalcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of liver damage from the more prevalent (75%–80%) and nonprogressive nonalcoholic fatty liver (NAFL) category to its less common and more ominous subset, nonalcoholic steatohe...

  • Article
  • Open Access
87 Citations
10,627 Views
9 Pages

Background: Tanacetum vulgare L. (Asteraceae) is a perennial herb that has been used to treat multiple ailments. Regional variability of the chemical composition of T. vulgare essential oils is well-known. Despite these regional chemotypes, most rele...

(This article belongs to the Special Issue Antimicrobial, Antioxidant and Anti-Inflammatory Activities of Essential Oils)
  • Review
  • Open Access
84 Citations
13,416 Views
77 Pages

Genus Stachys: A Review of Traditional Uses, Phytochemistry and Bioactivity

  • Ekaterina-Michaela Tomou,
  • Christina Barda and
  • Helen Skaltsa

29 September 2020

Background: The genus Stachys L. (Lamiaceae) includes about 300 species as annual or perennial herbs or small shrubs, spread in temperate regions of Mediterranean, Asia, America and southern Africa. Several species of this genus are extensively used...

(This article belongs to the Special Issue Research Topics in Medicines and How Our Board Members Are Engaged in Them)
  • Review
  • Open Access
81 Citations
9,419 Views
11 Pages

The control of infectious/parasitic diseases is a continuing challenge for global health, which in turn requires new methods of action and the development of innovative agents to be used in its prevention and/or treatment. In this context, the contro...

(This article belongs to the Special Issue Biological Potential and Medical Use of Secondary Metabolites)
  • Article
  • Open Access
80 Citations
10,289 Views
13 Pages

Anti-Lipase Potential of the Organic and Aqueous Extracts of Ten Traditional Edible and Medicinal Plants in Palestine; a Comparison Study with Orlistat

  • Nidal Jaradat,
  • Abdel Naser Zaid,
  • Fatima Hussein,
  • Maram Zaqzouq and ,
  • Hadeel Aljammal and
  • Ola Ayesh
  • + 1 author+ 0 author

8 December 2017

Background: Herbs have played a fundamental and essential role in the humans life since ancient times, especially those which are used as food and/or folk medicinedue to both their nutritive and curative properties.This study aimed to investigate new...

(This article belongs to the Special Issue Medicinal Plants and Foods)
  • Review
  • Open Access
77 Citations
8,209 Views
39 Pages

29 September 2020

Background: A large number of idiosyncratic drug induced liver injury (iDILI) and herb induced liver injury(HILI) cases of variable quality has been published but some are a matter of concern if the cases were not evaluated for causality using a robu...

(This article belongs to the Special Issue Research Topics in Medicines and How Our Board Members Are Engaged in Them)
  • Review
  • Open Access
75 Citations
14,283 Views
20 Pages

29 December 2018

Hydrogels are three-dimensional networks of hydrophilic polymers able to absorb and retain a considerable amount of water or biological fluid while maintaining their structure. Among these, thermo-sensitive hydrogels, characterized by a temperature-d...

(This article belongs to the Special Issue Nanoparticle and Liposome Based Novel Drug Delivery Systems)
  • Editorial
  • Open Access
75 Citations
9,153 Views
6 Pages

This Medicines special issue focuses on the great potential of secondary metabolites for therapeutic applications. The special issue contains 16 articles reporting relevant experimental results and overviews of bioactive secondary metabolites. Their...

(This article belongs to the Special Issue Biological Potential and Medical Use of Secondary Metabolites)
  • Review
  • Open Access
75 Citations
13,870 Views
34 Pages

Essential Oils and Their Components as Modulators of Antibiotic Activity against Gram-Negative Bacteria

  • Petruta Aelenei,
  • Anca Miron,
  • Adriana Trifan,
  • Alexandra Bujor and ,
  • Elvira Gille and
  • Ana Clara Aprotosoaie
  • + 1 author+ 0 author

Gram-negative bacteria cause infections that are difficult to treat due to the emergence of multidrug resistance. This review summarizes the current status of the studies investigating the capacity of essential oils and their components to modulate a...

(This article belongs to the Special Issue Essential Oils: Chemistry and Bioactivity)
  • Review
  • Open Access
73 Citations
9,853 Views
16 Pages

Evaluation of the Pharmaceutical Properties and Value of Astragali Radix

  • Amy G. W. Gong,
  • Ran Duan,
  • Huai Y. Wang,
  • Xiang P. Kong and ,
  • Tina T. X. Dong,
  • Karl W. K. Tsim and
  • Kelvin Chan
  • + 2 authors+ 0 author

Astragali Radix (AR), a Chinese materia medica (CMM) known as Huangqi, is an important medicine prescribed in herbal composite formulae (Fufang) by Traditional Chinese medicine (TCM) practitioners for thousands of years. According to the literature,...

(This article belongs to the Special Issue Bioactivities and Medical Use of Herbs and Plants)
  • Review
  • Open Access
73 Citations
8,026 Views
21 Pages

Food industry operates in a competitive market and is continually facing challenges to retain or even increase its market share. Consistent high-quality animal products are required to maintain consumer confidence and consumption. Enrichment of foods...

(This article belongs to the Special Issue Antimicrobial, Antioxidant and Anti-Inflammatory Activities of Essential Oils)
  • Review
  • Open Access
73 Citations
24,438 Views
18 Pages

Use of Herbal Medications for Treatment of Osteoarthritis and Rheumatoid Arthritis

  • Breanna N. Lindler,
  • Katelyn E. Long,
  • Nancy A. Taylor and
  • Wei Lei

28 October 2020

Arthritis is a chronic condition that affects nearly a quarter of the United States population. Osteoarthritis (OA) and rheumatoid arthritis (RA) are two major forms of arthritis associated with severe joint pain and reduced quality of life. Various...

  • Review
  • Open Access
70 Citations
10,584 Views
15 Pages

21 October 2018

Since ancient times, plants have been used to preserve food, or for their health properties. Essential oils are complex mixtures of volatile compounds that are obtained from botanical material, specifically from aromatic plants. Lamiaceae is one of t...

  • Article
  • Open Access
69 Citations
8,267 Views
12 Pages

Background: Common sage (Salvia officinalis) is a popular culinary and medicinal herb. A literature survey has revealed that sage oils can vary widely in their chemical compositions. The purpose of this study was to examine sage essential oil from di...

(This article belongs to the Special Issue Herbal Medicines and Functional Foods)
  • Review
  • Open Access
64 Citations
8,591 Views
21 Pages

23 November 2018

Neurodegenerative diseases have become a major challenge for public health because of their incurable status. Soft nanotechnology provides potential for slowing down the progression of neurodegenerative disorders by using innovative formulations of n...

(This article belongs to the Special Issue Nanoparticle and Liposome Based Novel Drug Delivery Systems)
  • Review
  • Open Access
64 Citations
16,646 Views
21 Pages

Mitragyna speciosa: Clinical, Toxicological Aspects and Analysis in Biological and Non-Biological Samples

  • Vânia Meireles,
  • Tiago Rosado,
  • Mário Barroso,
  • Sofia Soares and ,
  • Joana Gonçalves,
  • Ângelo Luís,
  • Débora Caramelo,
  • Ana Y. Simão,
  • Nicolás Fernández and
  • Eugenia Gallardo
  • + 6 authors+ 1 author

The abuse of psychotropic substances is a well-known phenomenon, and many of them are usually associated with ancestral traditions and home remedies. This is the case of Mitragyna speciosa (kratom), a tropical tree used to improve work performance an...

(This article belongs to the Special Issue Biological Potential and Medical Use of Secondary Metabolites)
  • Review
  • Open Access
64 Citations
37,847 Views
21 Pages

Safety Analysis of Panax Ginseng in Randomized Clinical Trials: A Systematic Review

  • Young-Sook Kim,
  • Jung-Yoon Woo,
  • Chang-Kyun Han and
  • Il-Moo Chang

8 June 2015

Background: Panax ginseng C.A. Meyer is one of the most frequently used herbs in the world. The roots of Panax ginseng have been used as a traditional tonic and medicine for thousands of years in Korea and China. Today, ginseng root is used as a diet...

  • Communication
  • Open Access
64 Citations
10,341 Views
10 Pages

Targeting Aberrant Sialylation to Treat Cancer

  • Jennifer Munkley and
  • Emma Scott

13 October 2019

Cell surface carbohydrates (known as glycans) are often aberrantly expressed or found at atypical levels in cancer. Glycans can impact all steps in tumour progression, from malignant transformation to metastasis, and have roles in all the cancer hall...

(This article belongs to the Special Issue Application of Glycobiology in the Treatment of Diseases)
  • Article
  • Open Access
62 Citations
12,169 Views
15 Pages

Chronic Pruritus Responding to Dupilumab—A Case Series

  • Lisa L. Zhai,
  • Kevin T. Savage,
  • Connie C. Qiu,
  • Annie Jin and ,
  • Rodrigo Valdes-Rodriguez and
  • Nicholas K. Mollanazar
  • + 1 author+ 0 author

Background: Chronic pruritus is defined as itch lasting for greater than six weeks. Pruritus is a burdensome manifestation of several internal and external disease states with a significant impact on quality of life. Dupilumab has shown promise in tr...

(This article belongs to the Special Issue Pathogenesis and Treatment of Chronic Pruritus)
  • Feature Paper
  • Review
  • Open Access
62 Citations
22,015 Views
60 Pages

Background: Traditional Chinese Medicine (TCM) with its focus on herbal use is popular and appreciated worldwide with increased tendency, although its therapeutic efficacy is poorly established for most herbal TCM products. Treatment was perceived as...

  • Review
  • Open Access
62 Citations
10,299 Views
68 Pages

Myrtus communis L. (myrtle) and Myrtus nivellei Batt. & Trab. (Saharan myrtle) have been used in folk medicine for alleviating some ailments. M. communis is largely distributed in the Mediterranean Basin, whereas M. nivellei is confined in specif...

(This article belongs to the Special Issue Antioxidant and Anti-Aging Action of Plant Polyphenols)
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