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Medicines 2016, 3(3), 19;

Essential Oils and Their Components as Modulators of Antibiotic Activity against Gram-Negative Bacteria

Department of Pharmacognosy, Faculty of Pharmacy, University of Medicine and Pharmacy Grigore T. Popa-Iasi, Universitatii 16, Iasi 700115, Romania
Regulatory Affairs Department, Fiterman Pharma LLC, Pacurari Road 127, Iasi 700544, Romania
Stejarul Biological Research Centre/National Institute of Research and Development for Biological Sciences, Alexandru cel Bun 6, Piatra Neamt 610004, Romania
Author to whom correspondence should be addressed.
Academic Editors: Lutfun Nahar, Norazah Basar and Satyajit D. Sarker
Received: 30 June 2016 / Revised: 17 July 2016 / Accepted: 18 July 2016 / Published: 28 July 2016
(This article belongs to the Special Issue Essential Oils: Chemistry and Bioactivity)
View Full-Text   |   Download PDF [553 KB, uploaded 28 July 2016]   |  


Gram-negative bacteria cause infections that are difficult to treat due to the emergence of multidrug resistance. This review summarizes the current status of the studies investigating the capacity of essential oils and their components to modulate antibiotic activity against Gram-negative bacteria. Synergistic interactions are particularly discussed with reference to possible mechanisms by which essential oil constituents interact with antibiotics. Special emphasis is given to essential oils and volatile compounds that inhibit efflux pumps, thus reversing drug resistance in Gram-negative bacteria. In addition, indifference and antagonism between essential oils/volatile compounds and conventional antibiotics have also been reported. Overall, this literature review reveals that essential oils and their purified components enhance the efficacy of antibiotics against Gram-negative bacteria, being promising candidates for the development of new effective formulations against Gram-negative bacteria. View Full-Text
Keywords: essential oils; Gram-negative bacteria; multidrug-resistance; antibiotics; synergistic interactions essential oils; Gram-negative bacteria; multidrug-resistance; antibiotics; synergistic interactions

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Aelenei, P.; Miron, A.; Trifan, A.; Bujor, A.; Gille, E.; Aprotosoaie, A.C. Essential Oils and Their Components as Modulators of Antibiotic Activity against Gram-Negative Bacteria. Medicines 2016, 3, 19.

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