Next Article in Journal
Editorial for Special Issue on Herbal Medicines and Natural Products
Next Article in Special Issue
The Changing Landscape of Breast Cancer: How Biology Drives Therapy
Previous Article in Journal
eMindfulness Therapy—A Study on Efficacy of Blood Pressure and Stress Control Using Mindful Meditation and Eating Apps among People with High Blood Pressure
Article Menu

Export Article

Open AccessReview
Medicines 2015, 2(4), 310-327; doi:10.3390/medicines2040310

Exosomes: Potential in Cancer Diagnosis and Therapy

Department of Pathology and Laboratory Medicine, University of Vermont, College of Medicine, Burlington, VT 05405, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Daniel M.-Y. Sze and William Chi-shing Cho
Received: 24 September 2015 / Revised: 20 October 2015 / Accepted: 26 October 2015 / Published: 2 November 2015
(This article belongs to the Special Issue Recent Advance in Targeted Therapy in Medicine)
View Full-Text   |   Download PDF [2021 KB, uploaded 2 November 2015]   |  

Abstract

Exosomes are membrane-bound, intercellular communication shuttles that are defined by their endocytic origin and size range of 30–140 nm. Secreted by nearly all mammalian cell types and present in myriad bodily fluids, exosomes confer messages between cells, proximal and distal, by transporting biofunctional cargo in the form of proteins, nucleic acids, and lipids. They play a vital role in cellular signaling in both normal physiology and disease states, particularly cancer. Exosomes are powerful progenitors in altering target cell phenotypes, particularly in tumorigenesis and cancer progression, with the ability to alter tumor microenvironments and to assist in establishing the pre-metastatic niche. Many aspects of exosomes present them as novel means to identify cancer biomarkers for early detection and therapeutic targets, and using intrinsic and engineered characteristics of exosomes as therapeutic devices to ameliorate the progression of the disease. This review outlines some of the recent and major findings with regard to exosomes in cancer, and their utilization as therapeutic tools. View Full-Text
Keywords: exosomes; cancer; therapy; biomarkers; tumor microenvironment; pre-metastatic niche exosomes; cancer; therapy; biomarkers; tumor microenvironment; pre-metastatic niche
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Munson, P.; Shukla, A. Exosomes: Potential in Cancer Diagnosis and Therapy. Medicines 2015, 2, 310-327.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Medicines EISSN 2305-6320 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top