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Metal Based Nano and Microparticles for Drug Delivery and Antibacterial Applications

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Special Issue Information

Dear Colleagues,

Due to the outbreak of infectious diseases caused by different pathogenic microorganisms and antibiotic resistance development, pharmaceutical companies and researchers search for new agents.Applied changes by the mankind to the ecosystem created severe worldwide challenges that had better to be addressed via advanced technological features. In this matter context, the development of new materials such as Metal Based Nano particles and the fabrication of high-performance materials created a proper opportunity for authorities to replace common for Biomedical Applications platforms with novel technologies based on nanomaterials. Among the most attractive ones, Metal Based Nano particles have attracted noteworthy attention and revolutionize features of Biomedical Applications platforms and advanced drug delivery and Antibicrobial. In recent decades, Metal Based Nano particles have emerged as novel antimicrobial agents due to their high surface area to volume ratio and unique chemical and physical properties, so some are already applied in clinical dressing and antimicrobial surfaces. Current Special Issue tried to bring together the new trends and studies in antimicrobial and drug delivery applications of Metal Based Nano particles in various fields. This Special Issue is welcome to recent signs of progress in synthesis, especially green and bio synthesis, characterization of Metal Based Nano particles, especially -for Biomedical and newly emerged.

Dr. Seyyed Mojtaba Mousavi
Dr. Ahmad Gholami
Dr. Wei-Hung Chiang
Guest Editors

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Keywords

metal based nano particles
antibacterial
nano biomedical
drug delivery

Published Papers (2 papers)

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Research

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16 pages, 3873 KiB

Open AccessFeature PaperArticle

Biosynthesis and Antimicrobial Evaluation of Zinc Oxide Nanoparticles Using Chlorella vulgaris Biomass against Multidrug-Resistant Pathogens

by Mohammad Hossein Morowvat, Kimia Kazemi, Maral Ansari Jaberi, Abbas Amini and Ahmad Gholami

Materials 2023, 16(2), 842; https://doi.org/10.3390/ma16020842 - 15 Jan 2023

Cited by 14 | Viewed by 2240

Abstract

The rampant increase in antibiotic resistance has created a global barrier to the treatment of multidrug-resistant infections. Biogenic synthesis of nanomaterials is a novel approach to producing nanostructures with biological resources. Algae are known to be clean, nontoxic, cost-beneficial, and environmentally acceptable. Chlorella vulgaris is a popular microalga for its broad applications in food, supplements, pharmaceuticals, and cosmetics. In this study, we used Chlorella vulgaris biomass lyophilized powder as our green resource for the biosynthesis ZnONPs. Chlorella vulgaris culture was harvested at the end of the logarithmic phase, and the biomass was lyophilized. ZnONPs were synthesized using lyophilized biomass and 20 mM zinc acetate dihydrate at a temperature of 70 °C and continuous stirring in a water bath overnight. At the end of the reaction, UV–Vis absorption of colloidal suspension proved the synthesis of ZnONPs. The physicochemical characteristics of nanoparticles were analyzed using FTIR, DLS, TEM, and XRD. Based on FTIR spectra. The antibacterial activity of green synthesized nanostructures was evaluated against methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). The synthesized ZnONPs have oxygen-containing groups on the surface that show the synthesized nanoparticles’ stabilization. The Zeta potential was −27.4 mV, and the mean particle size was measured as 33.4 nanometers. Biogenic ZnONPs produced in this method have a notable size distribution and excellent surface energy, which can have vast applications like antimicrobial potential in pharmaceuticals as topical forms. Additionally, in order to evaluate the antimicrobial activity of ZnO nanoparticles, we used MRSA and VRE strains and the results showed the anti-MRSA activity at 400 and 625 μg mL⁻¹, respectively. Thus, these biogenic ZnO nanoparticles revealed a substantial antibacterial effect against multidrug-resistant pathogens, associated with several serious systemic infections, and have the potential as an antimicrobial agent for further study. Full article

(This article belongs to the Special Issue Metal Based Nano and Microparticles for Drug Delivery and Antibacterial Applications)

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Review

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27 pages, 13086 KiB

Open AccessReview

Innovative Metal-Organic Frameworks for Targeted Oral Cancer Therapy: A Review

by Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Fatemeh Fallahi Nezhad, Mojtaba Binazadeh, Milad Dehdashtijahromi, Navid Omidifar, Yasamin Ghahramani, Chin Wei Lai, Wei-Hung Chiang and Ahmad Gholami

Materials 2023, 16(13), 4685; https://doi.org/10.3390/ma16134685 - 29 Jun 2023

Cited by 5 | Viewed by 2107

Abstract

Metal-organic frameworks (MOFs) have proven to be very effective carriers for drug delivery in various biological applications. In recent years, the development of hybrid nanostructures has made significant progress, including developing an innovative MOF-loaded nanocomposite with a highly porous structure and low toxicity that can be used to fabricate core-shell nanocomposites by combining complementary materials. This review study discusses using MOF materials in cancer treatment, imaging, and antibacterial effects, focusing on oral cancer cells. For patients with oral cancer, we offer a regular program for accurately designing and producing various anticancer and antibacterial agents to achieve maximum effectiveness and the lowest side effects. Also, we want to ensure that the anticancer agent works optimally and has as few side effects as possible before it is tested in vitro and in vivo. It is also essential that new anticancer drugs for cancer treatment are tested for efficacy and safety before they go into further research. Full article

(This article belongs to the Special Issue Metal Based Nano and Microparticles for Drug Delivery and Antibacterial Applications)

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