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Open AccessFeature PaperCommunication
Mar. Drugs 2018, 16(6), 185; https://doi.org/10.3390/md16060185

Angucycline Glycosides from Mangrove-Derived Streptomyces diastaticus subsp. SCSIO GJ056

1
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China
2
University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 110039, China
3
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China
4
Syngenta Jealott’s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK
*
Authors to whom correspondence should be addressed.
Received: 15 May 2018 / Revised: 22 May 2018 / Accepted: 25 May 2018 / Published: 28 May 2018
(This article belongs to the Special Issue Marine Glycosides)
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Abstract

Nine new angucycline glycosides designated urdamycins N1–N9 (19), together with two known congener urdamycins A (10) and B (11), were obtained from a mangrove-derived Streptomyces diastaticus subsp. SCSIO GJ056. The structures of new compounds were elucidated on the basis of extensive spectroscopic data analysis. The absolute configurations of 69 were assigned by electronic circular dichroism calculation method. Urdamycins N7 (7) and N8 (8) represent the first naturally occurring (5R, 6R)-angucycline glycosides, which are diastereomers of urdamycins N6 (6) and N9 (9), respectively. View Full-Text
Keywords: mangrove-derived Streptomyces; angucycline; urdamycin mangrove-derived Streptomyces; angucycline; urdamycin
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Gui, C.; Liu, Y.; Zhou, Z.; Zhang, S.; Hu, Y.; Gu, Y.-C.; Huang, H.; Ju, J. Angucycline Glycosides from Mangrove-Derived Streptomyces diastaticus subsp. SCSIO GJ056. Mar. Drugs 2018, 16, 185.

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