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Mar. Drugs 2018, 16(3), 92; https://doi.org/10.3390/md16030092

Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae

1
Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China
2
First Motorized Detachment of Shanghai Armed Police Corps, Shanghai 200126, China
3
Nuclear Magnetic Resonance Center, Xi’an Modern Chemistry Research Institute, Xi’an 710065, China
*
Author to whom correspondence should be addressed.
Received: 7 February 2018 / Revised: 28 February 2018 / Accepted: 10 March 2018 / Published: 13 March 2018
(This article belongs to the Special Issue Marine Glycosides)
View Full-Text   |   Download PDF [679 KB, uploaded 13 March 2018]   |  

Abstract

Four new polyhydroxysteroidal glycosides—culcinosides A–D (1, 2, 4, and 7)—along with three known compounds—echinasteroside C (3), linckoside F (5), and linckoside L3 (6)—were isolated from the ethanol extract of starfish Culcita novaeguineae collected from the Xisha Islands of the South China Sea. The structures of new compounds were elucidated through extensive spectroscopic studies and chemical evidence, especially two-dimensional (2D) NMR techniques. The cytotoxicity of the new compounds against human glioblastoma cell lines U87, U251, and SHG44 were evaluated. View Full-Text
Keywords: Culcita novaeguineae; starfish; polyhydroxysteroidal glycoside; cytotoxicity Culcita novaeguineae; starfish; polyhydroxysteroidal glycoside; cytotoxicity
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Lu, Y.; Li, H.; Wang, M.; Liu, Y.; Feng, Y.; Liu, K.; Tang, H. Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae. Mar. Drugs 2018, 16, 92.

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